Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ram P Naikawadi"'
Autor:
Supparerk Disayabutr, Eun Kyung Kim, Seung-Ick Cha, Gary Green, Ram P Naikawadi, Kirk D Jones, Jeffrey A Golden, Aaron Schroeder, Michael A Matthay, Jasleen Kukreja, David J Erle, Harold R Collard, Paul J Wolters
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158367 (2016)
Pathologic features of idiopathic pulmonary fibrosis (IPF) include genetic predisposition, activation of the unfolded protein response, telomere attrition, and cellular senescence. The mechanisms leading to alveolar epithelial cell (AEC) senescence a
Externí odkaz:
https://doaj.org/article/ac0a230622e74802850efa5030484819
Autor:
Cory Wilson, Tinne C.J. Mertens, Pooja Shivshankar, Weizen Bi, Scott D. Collum, Nancy Wareing, Junsuk Ko, Tingting Weng, Ram P. Naikawadi, Paul J. Wolters, Pascal Maire, Soma S.K. Jyothula, Rajarajan A. Thandavarayan, Dewei Ren, Nathan D. Elrod, Eric J. Wagner, Howard J. Huang, Burton F. Dickey, Heide L. Ford, Harry Karmouty-Quintana
Publikováno v:
JCI Insight. 7
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. The role of the developmental transcription factor Sine oculis homeobox homolog 1 (SIX1) in the pathophysiology of lung fibrosis is not known. IPF lung tissue samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a804ceb1639be76b34c65441f1b3e6c
https://doi.org/10.1172/jci.insight.142984
https://doi.org/10.1172/jci.insight.142984
Autor:
Ram P. Naikawadi, Young-Kwon Hong, Peter Baluk, Paul J. Wolters, Dongwon Choi, Shineui Kim, Felipe Rodriguez, Donald M. McDonald
Publikováno v:
Am J Pathol
The American journal of pathology, vol 190, iss 12
The American journal of pathology, vol 190, iss 12
Despite many reports about pulmonary blood vessels in lung fibrosis, the contribution of lymphatics to fibrosis is unknown. We examined the mechanism and consequences of lymphatic remodeling in mice with lung fibrosis after bleomycin injury or telome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51bd425667552aa3eb2905e1a0801af
https://doi.org/10.1016/j.ajpath.2020.08.018
https://doi.org/10.1016/j.ajpath.2020.08.018
Autor:
Aritra Bhattacharyya, Ram P. Naikawadi, Anil Bhushan, Rachel Hatano, Shivani Arora, Yao Wang, Paul J. Wolters, Mallar Bhattacharya, Hara Apostolopoulou, Peter Thompson, Suneil K. Koliwad, Ajit Shah
Publikováno v:
Med (N Y)
Summary Background The failure of immune surveillance to remove senescent cells drives age-related diseases. Here, we target an endogenous immune surveillance mechanism that can promote elimination of senescent cells and reverse disease progression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f636cef8dad7f6bd849d097ef4999343
https://pubmed.ncbi.nlm.nih.gov/34617070
https://pubmed.ncbi.nlm.nih.gov/34617070
Autor:
Ram P. Naikawadi, Paul J. Wolters
Publikováno v:
Eur Respir J
Danger signals, or damage-associated molecular patterns (DAMPs), instigate mitochondrial innate immune responses wherein Mitochondrial Antiviral Signaling protein (MAVS) functions as a key platform molecule to mediate them. The role of MAVS in the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b02b8dfd50c1a84a5fea56b37ed354
https://pubmed.ncbi.nlm.nih.gov/33093124
https://pubmed.ncbi.nlm.nih.gov/33093124
Autor:
Natalia Achtar-Zadeh, Julia E. Mieleszko, Paul J. Wolters, Ram P. Naikawadi, Gary M. Green, Isabel Arnould, Kirk D. Jones, John R. Greenland, Jasleen Kukreja
Publikováno v:
American journal of respiratory cell and molecular biology, vol 63, iss 4
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
Telomere dysfunction is associated with multiple fibrotic lung processes, including chronic lung allograft dysfunction (CLAD)—the major limitation to long-term survival following lung transplantation. Although shorter donor telomere lengths are ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e41d8af74be1d2d23f95579eabd09ee
https://escholarship.org/uc/item/87f7516t
https://escholarship.org/uc/item/87f7516t
Autor:
Ram P. Naikawadi
Publikováno v:
Thorax. 75:200-201
Idiopathic pulmonary fibrosis (IPF) is a chronic age-related disease with increasing prevalence that is characterised by progressive loss of lung function, which contributes to accelerated morbidity and mortality. While the exact aetiology is unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faff960e0c25b12a82f67c9197313cb9
https://doi.org/10.1136/thoraxjnl-2019-214374
https://doi.org/10.1136/thoraxjnl-2019-214374
Autor:
Julia E. Mieleszko, Jasleen Kukreja, Ram P. Naikawadi, Paul J. Wolters, John R. Greenland, Gary M. Green, Natalia Achtar-Zadeh, Kirk D. Jones
RationaleTelomere dysfunction is associated with multiple fibrotic lung processes, including chronic lung allograft dysfunction (CLAD) which is a major limitation to long-term survival following lung transplantation. Although shorter donor telomere l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db281eec1e157e6eb6703a011859861c
https://doi.org/10.1101/746768
https://doi.org/10.1101/746768
Autor:
Austin Hsu, Agnieszka P. Looney, Valerie Fong, Atul J. Butte, Paul J. Wolters, Esther Wu, Leqian Liu, Ram P. Naikawadi, Adam R. Abate, Dvir Aran, Mallar Bhattacharya, Suzanna Chak
Publikováno v:
Nature immunology, vol 20, iss 2
Nature immunology
Nature immunology
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific subgroups in supporting fibrogenesis has not been investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a74362bd84fb82795abe802dd2f479f
https://escholarship.org/uc/item/9d56n758
https://escholarship.org/uc/item/9d56n758
Autor:
Ram P. Naikawadi, Paul J. Wolters, Hong-Erh Liang, Prescott G. Woodruff, Richard M. Locksley, Steven J. Van Dyken, David J. Erle
Publikováno v:
Cell, vol 169, iss 3
The environmentally widespread polysaccharide chitin is degraded and recycled by ubiquitous bacterial and fungal chitinases. Although vertebrates express active chitinases from evolutionarily conserved loci, their role in mammalian physiology is uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c245fb5ae3b85e0a6a16924ce76722a3
https://pubmed.ncbi.nlm.nih.gov/28431248
https://pubmed.ncbi.nlm.nih.gov/28431248