Výsledky vyhledávání - "Ram Murthi Bestha"

Akademický článek

Validated HPLC method for quantification of copanlisib in mice plasma: application to a pharmacokinetic study

Autor: Ashok Zakkula, Pavan Kumar Kurakula, Sreekanth Dittakavi, Prasanthi Daram, Ram Murthi Bestha, Mohd Zainuddin, Ravi Kumar Trivedi, Ramesh Mullangi

Publikováno v: ADMET and DMPK, Vol 8, Iss 1, Pp 113-121 (2020)

Copanlisib is a pan phosphatidylinositol 3-kinase (PI3K) inhibitor approved for follicular lymphoma. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of co

Externí odkaz: https://doaj.org/article/4df85a94e3de48d495394a05befcbc07

Zobrazit plný text záznamu

Development and Validation of an HPLC Method for Quantification of Filgotinib, a Novel JAK-1 Inhibitor in Mice Plasma: Application to a Pharmacokinetic Study

Autor: Ashok Zakkula, Ramesh Mullangi, Ram Murthi Bestha, Ravi Kumar Trivedi, Sreekanth Dittakavi, Shobha Pulipati, Mohd Zainuddin

Publikováno v: Drug Research. 70:233-238

Filgotinib is a selective JAK1 (Janus kinase) inhibitor, filed in Japan for the treatment of rheumatoid arthritis. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbd49cdc699e7c92f12c305a33c6f94
https://doi.org/10.1055/a-1141-3475

Zobrazit plný text záznamu

Enantioselective in vitro ADME, absolute oral bioavailability, and pharmacokinetics of (-)-lumefantrine and (+)-lumefantrine in mice

Autor: Balaji Narayanan, Ramesh Mullangi, Bhavesh Babulal Gabani, Vinay Kiran, Ram Murthi Bestha, Nuggehally R. Srinivas, Abhishek Dixit

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 51(2)

Lumefantrine (LFN) is a chiral antimalarial drug. Enantioselective in vitro attributes and absolute oral pharmacokinetics for (-)-LFN and (+)-LFN have been characterized in mice. No stereoselectivity was seen with either of the enantiomers when compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90b3556135e7cd8dad6b58e1c5bbdc2
https://pubmed.ncbi.nlm.nih.gov/32930648

Zobrazit plný text záznamu

A dried blood spot assay with HPLC-MS/MS for the determination of larotrectinib in mouse blood and its application to a pharmacokinetic study

Autor: Ram Murthi Bestha, Nair S.V. Manju, Sreekanth Dittakavi, Harsha K. Tripathy, Ramesh Mullangi

Publikováno v: Biomedical chromatography : BMCREFERENCES. 34(12)

Larotrectinib is a first-generation tropomyosin kinase inhibitor, approved for the treatment of solid tumors. In this paper, we present a validated dried blood spot (DBS) method for the quantitation of larotrectinib from mouse blood using HPLC-MS/MS,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abf54edc95c4a38b095834665a56ce1
https://pubmed.ncbi.nlm.nih.gov/32706402

Zobrazit plný text záznamu

Validated HPLC Method for Quantification of a Novel Trk Inhibitor, Larotrectinib in Mice Plasma: Application to a Pharmacokinetic Study

Autor: Ram Murthi Bestha, S.V. Nair Manju, Ashok Zakkula, Ramesh Mullangi, Sreekanth Dittakavi, Harsha K. Tripathy

Publikováno v: Drug research. 70(2-03)

Larotrectinib, is an orally active novel small molecule approved for the treatment of solid tumors in pediatrics and adult patients. It acts by inhibiting tropomyosin receptor kinase. In this paper, we report the development and validation of a high-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53254d9deff267b700e20bf5823aa21
https://pubmed.ncbi.nlm.nih.gov/31931548

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání