Breaching the Barrier: Genome-Wide Investigation into the Role of a Primary Amine in Promoting E. coli Outer-Membrane Passage and Growth Inhibition by Ampicillin

Autor: Claire Maher, Ram Maharjan, Geraldine Sullivan, Amy K. Cain, Karl A. Hassan

Publikováno v: Microbiology Spectrum, Vol 10, Iss 6 (2022)

ABSTRACT Gram-negative bacteria are problematic for antibiotic development due to the low permeability of their cell envelopes. To rationally design new antibiotics capable of breaching this barrier, more information is required about the specific co

Externí odkaz: https://doaj.org/article/d2f0d86292bc4ec58be66ebf767e3a63

Cross-protection and cross-feeding between ESKAPE pathogens Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence

Autor: Lucie Semenec, Amy Cain, Catherine Dawson, Qi Liu, Hue Dinh, Hannah Lott, Anahit Penesyan, Ram Maharjan, Francesca Short, Karl Hassan, Ian Paulsen

Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens frequently co-isolated from polymicrobial infections. The infections where these pathogens co-exist can be more severe and recalcitrant to therapy than infections caused by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4927ffabb5eec7a3dd27f42f6df03be7
https://doi.org/10.21203/rs.3.rs-1184776/v1

Management and spatial resolution effects on yield and water balance at regional scale in crop models

Autor: Eric Casellas, Edwin Haas, Frank Ewert, Matthias Kuhnert, Thomas Gaiser, Jacques-Eric Bergez, Xenia Specka, Zhigan Zhao, Jagadeesh Yeluripati, Helene Raynal, Ganga Ram Maharjan, Luca Doro, Enli Wang, Ana Villa, Giacomo Trombi, Holger Hoffmann, Marco Bindi, Julie Constantin, Balász Grosz, Claas Nendel, Kurt Christian Kersebaum, Lutz Weihermüller, Henrik Eckersten, Steffen Klatt, Pier Paolo Roggero, Elisabet Lewan, Marco Moriondo

Publikováno v: Agricultural and Forest Meteorology
Agricultural and Forest Meteorology, Elsevier Masson, 2019, 275, pp.184-195. ⟨10.1016/j.agrformet.2019.05.013⟩
Agricultural and forest meteorology 275, 184-195 (2019). doi:10.1016/j.agrformet.2019.05.013

International audience; Due to the more frequent use of crop models at regional and national scale, the effects of spatial data input resolution have gained increased attention. However, little is known about the influence of variability in crop mana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0250b0647d16cabdc49f57026e3d29
https://doi.org/10.1016/j.agrformet.2019.05.013

The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

Autor: Saleh F. Alquethamy, Ram Maharjan, Karl A. Hassan, Natasha N Delgado, Maoge Zang, James C. Paton, Amy K. Cain, Felise G. Adams, Bart A. Eijkelkamp, Ian T. Paulsen, Christopher A. McDevitt

Acinetobacter species are ubiquitous Gram-negative bacteria that can be found in water, soil and as commensals of the human skin. The successful inhabitation of Acinetobacter species in diverse environments is primarily attributable to the expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5131061b0f4f540e7766439824d23761
https://doi.org/10.1101/2020.10.20.348086

How antibiotics work together: molecular mechanisms behind combination therapy

Autor: Geraldine J. Sullivan, Natasha N Delgado, Ram Maharjan, Amy K. Cain

Publikováno v: Current opinion in microbiology. 57

Antibiotics used in combination are an effective strategy for combatting numerous infectious diseases in clinical and veterinary settings, particularly as a last-line therapy for difficult-to-treat cases. Combination therapy can either increase or sl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaf353253219e5eab72c56341fea3eb
https://pubmed.ncbi.nlm.nih.gov/32619833