Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Ram Madabhushi"'
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113809- (2024)
Summary: We trapped catalytically engaged topoisomerase IIβ (TOP2B) in covalent DNA cleavage complexes (TOP2Bccs) and mapped their positions genome-wide in cultured mouse cortical neurons. We report that TOP2Bcc distribution varies with both nucleos
Externí odkaz:
https://doaj.org/article/94331674ade94e929595ea7c831a18a7
Autor:
Morgan Crewe, Ram Madabhushi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant
Externí odkaz:
https://doaj.org/article/28d051b1724940e0bb7fe3239781cf3d
Autor:
Ilse Delint-Ramirez, Ram Madabhushi
Publikováno v:
Molecular Cell. 83:1208-1209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0341a1686dcdbce9b5a055da637996d2
https://doi.org/10.1016/j.molcel.2023.03.019
https://doi.org/10.1016/j.molcel.2023.03.019
Autor:
Ram Madabhushi
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1917 (2018)
Type IIA topoisomerases allow DNA double helical strands to pass through each other by generating transient DNA double strand breaks βDSBs), and in so doing, resolve torsional strain that accumulates during transcription, DNA replication, chromosome
Externí odkaz:
https://doaj.org/article/27598c3abcab4bf1b588a7cd9b4f907c
Autor:
Ilse Delint-Ramirez, Lahiri Konada, Lance Heady, Richard Rueda, Alvaro Sebastian Vaca Jacome, Eric Marlin, Charlotte Marchioni, Amir Segev, Oleg Kritskiy, Satoko Yamakawa, Andrew H. Reiter, Li-Huei Tsai, Ram Madabhushi
Publikováno v:
Molecular cell. 82(20)
Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their transcription, and yet, the mechanisms that control Top2B-mediated DSB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0440e1bdcc2bbfa319de6c055fcaddd
https://pubmed.ncbi.nlm.nih.gov/36206766
https://pubmed.ncbi.nlm.nih.gov/36206766
Autor:
Tae Kyung Kim, Ram Madabhushi
Publikováno v:
Molecular and Cellular Neuroscience. 87:27-34
In this review, we attempt to discuss emerging themes in the regulation of neuronal activity-regulated genes, focusing primarily on an important subset of immediate-early genes. We first discuss earlier studies that have illuminated the role of cis-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508aa8936db0f35c0e899675761fc279
https://doi.org/10.1016/j.mcn.2017.11.009
https://doi.org/10.1016/j.mcn.2017.11.009
Autor:
Trongha X. Phan, Ram Madabhushi, Sukhee Cho, Andreas R. Pfenning, Alexi Nott, Ling Pan, Fan Gao, Manolis Kellis, Satoko Yamakawa, Jinsoo Seo, Ryan T. Stott, Elizabeta Gjoneska, Ping-Chieh Pao, Richard Rueda, Hidekuni Yamakawa, Li-Huei Tsai
Publikováno v:
PMC
Neuronal activity causes the rapid expression of immediate early genes that are crucial for experience-driven changes to synapses, learning, and memory. Here, using both molecular and genome-wide next-generation sequencing methods, we report that neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ad16e34b4f9014e062eab1736916da
Autor:
Huimei Yu, Ram Madabhushi, Justyna Cholewa-Waclaw, Melanie J. von Schimmelmann, Li-Huei Tsai, Hongjun Song, Anne Schaefer, Adrian Bird
Publikováno v:
Society for Neuroscience
Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and in response to environmental stimuli. In addition to its fundamental c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf9f9605eec633ac44bd87e28db51c5
https://pubmed.ncbi.nlm.nih.gov/27911745
https://pubmed.ncbi.nlm.nih.gov/27911745
Autor:
Omer Durak, Ram Madabhushi, Birgit Schwanke, Melanie Richter, Li-Huei Tsai, Johannes Gräff, Froylan Calderon de Anda, Alison E. Mungenast, Jia Meng, Damien Rei, Konstantinos Meletis
Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3119cf01776a28b69b0b5550fcabfbec
https://europepmc.org/articles/PMC5034108/
https://europepmc.org/articles/PMC5034108/
Actin Homolog MreB Affects Chromosome Segregation by Regulating Topoisomerase IV in Escherichia coli
Autor:
Ram Madabhushi, Kenneth J. Marians
Publikováno v:
Molecular Cell. 33(2):171-180
In Escherichia coli, topoisomerase IV, a type II topoisomerase, mediates the resolution of topological linkages between replicated daughter chromosomes and is essential for chromosome segregation. Topo IV activity is restricted to only a short interv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fed936be4bd90e2b38f45f4d552d48