Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ram K. Sindhu"'
Autor:
Christian K. Roberts, Ashkan Ehdaie, R. James Barnard, Ram K. Sindhu, Nosratola D. Vaziri, Michael J. Jurczak
Publikováno v:
Metabolism. 55:928-934
Previously, we have demonstrated that chronic consumption of a high-fat, high-refined sugar (HFS) diet results in metabolic syndrome which is marked by obesity, insulin resistance, hyperlipidemia, and hypertension in Fischer rats. Metabolic syndrome
Autor:
Kunal K. Sindhu, Christian K. Roberts, Ja-Ryung Koo, Ram K. Sindhu, Ashkan Ehdaie, Farbod Farmand
Publikováno v:
Free Radical Research. 40:921-928
The present investigation was carried out to study the expression of major cytochrome P450 (CYP) isozymes in streptozotocin-induced diabetes with concomitant insulin therapy. Male Sprague-Dawley rats were randomly assigned to untreated control, strep
Publikováno v:
Antioxidants & Redox Signaling. 7:1269-1274
Chronic exposure to low doses of lead results in generation of reactive oxygen species, reduced nitric oxide availability, and arterial hypertension. The present studies were done to define if other conditions associated with oxidative stress, such a
Autor:
Farbod Farmand, Tri Nguyen, Christian K. Roberts, Kanwaljit K. Dhaliwal, Ashkan Ehdaie, Ram K. Sindhu, Chang-De Zhan, Nosratola D. Vaziri
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1743:86-92
Chronic renal failure (CRF) is associated with oxidative stress, the precise mechanism of which is yet to be elucidated. The present study was undertaken to investigate in renal insufficiency the expression of catalase and glutathione peroxidase, whi
Publikováno v:
Life Sciences. 76:945-953
Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same anim
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1690:231-237
Chronic renal failure (CRF) has been documented to cause oxidative stress and alter nitric oxide (NO) metabolism. However, the effect of CRF on proteins related to NO bioactivity has not been investigated. The present study was designed to test the h
Publikováno v:
Free Radical Biology and Medicine. 36:330-339
Oxidative stress and nitrosative stress play important roles in the pathogenesis of secondary spinal cord injury. Recently, we demonstrated that peripheral nerve grafts (PNG) with acidic fibroblast growth factor (aFGF) partially restore hind limb loc
Publikováno v:
Kidney International. 65(1):219-227
Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation. Background Spontaneously hypertensive rats (SHR) are born normotensive and develop hypertension (HTN) later in life (age 4 to 5weeks). H
Publikováno v:
Clinical and Experimental Hypertension. 26:43-53
Recent evidence suggests that impaired antioxidant status is involved in oxidative stress associated with diabetes. The main antioxidant enzymes include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). The aim of the prese
Publikováno v:
Hypertension. 41:341-346
Previous studies have demonstrated that oxidative stress contributes to hypertension and treatments with either antioxidant or immunosuppressive/anti-inflammatory agents improve hypertension in spontaneously hypertensive rats (SHR). The present study