Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Ram K. Mishra"'
Autor:
Shane K. B. Taylor, Muhammad H. Minhas, Justin Tong, P. Ravi Selvaganapathy, Ram K. Mishra, Bhagwati P. Gupta
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The nematode C. elegans is a leading model to investigate the mechanisms of stress-induced behavioral changes coupled with biochemical mechanisms. Our group has previously characterized C. elegans behavior using a microfluidic-based electrot
Externí odkaz:
https://doaj.org/article/1cbde93eba784304bb79dd9f9b099913
Publikováno v:
ACS Omega, Vol 5, Iss 43, Pp 28375-28381 (2020)
Externí odkaz:
https://doaj.org/article/4b448d035ad54146b182fd9863cd68aa
Autor:
Judith Tran, Shane K.B. Taylor, Anika Gupta, Niranjana Amin, Harish Pant, Bhagwati P. Gupta, Ram K. Mishra
Publikováno v:
Current Research in Neurobiology, Vol 2, Iss , Pp 100006- (2021)
Parkinson’s Disease (PD) is a chronic progressive neurodegenerative disease. Current treatments for PD are symptomatic and only increase striatal dopamine levels. Proactive neuroprotective approaches that slow the progression of PD and maintain app
Externí odkaz:
https://doaj.org/article/4d8c304bddba48bc9a9dacb9f7347148
Autor:
Ritesh P. Daya, Jayant Bhandari, Sharnpreet K. Kooner, Joella Ho, Christopher D. Rowley, Nicholas A. Bock, Troy Farncombe, Ram K. Mishra
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson’s disease and haloperidol-induced extrapyramidal m
Externí odkaz:
https://doaj.org/article/35e1aeacea904b069f84bd70655ba3fc
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 204-214 (2013)
A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission. Photoaffinity labeling ligands based upon PLG peptidom
Externí odkaz:
https://doaj.org/article/b6594288ac8d4f60807a3974fc842d42
Publikováno v:
NeuroToxicology. 91:321-328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d4e8002f3ef9759b916851c5d6bf1a6
https://doi.org/10.1016/j.neuro.2022.06.004
https://doi.org/10.1016/j.neuro.2022.06.004
Publikováno v:
CNS Drugs. 36:739-770
While the intranasal administration of drugs to the brain has been gaining both research attention and regulatory success over the past several years, key fundamental and translational challenges remain to fully leveraging the promise of this drug de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73d639475895e10057d36dcf53b647e
https://doi.org/10.1007/s40263-022-00930-4
https://doi.org/10.1007/s40263-022-00930-4
Autor:
Jai S. Singh, null Sajeev T.K., Rajlaxmi Panigrahi, Pearl Cherry, Nimisha A. Panchakshari, Vaibhav K. Shukla, Ashutosh Kumar, Ram K. Mishra
Publikováno v:
Biophys J
The endoparasitic pathogen, Plasmodium falciparum (Pf), modulates protein-protein interactions to employ post-translational modifications like SUMOylation to establish successful infections. The interaction between E1 and E2 (Ubc9) enzymes governs sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567fb63afceebf759e91d9ea186432f6
https://doi.org/10.1016/j.bpj.2022.03.022
https://doi.org/10.1016/j.bpj.2022.03.022
Autor:
Ritesh Daya, Ram K. Mishra, Hetshree Joshi, Yuxin Tian, Jayant Bhandari, Vidhi Patel, Sharon Thomson
Publikováno v:
International Journal of Peptide Research and Therapeutics. 27:2551-2557
Impairment in dopaminergic pathways has been implicated in several detrimental neuropsychiatric and neurodegenerative disorders, including schizophrenia and Parkinson’s disease. Current approved therapeutic drugs for such conditions treat the sympt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90271b99aaa0175ea7484c5641da026
https://doi.org/10.1007/s10989-021-10272-2
https://doi.org/10.1007/s10989-021-10272-2
Publikováno v:
Current Molecular Pharmacology. 14:469-476
Background: Allosteric modulators of G-protein coupled receptors regulate receptor activity by binding to sites other than the active site and have emerged as a new and highly desirable class of drugs. PAOPA (3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acff19f7a26224d578a4d8ffa761e2f
https://doi.org/10.2174/1874467213666200910091007
https://doi.org/10.2174/1874467213666200910091007