Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Ram I, Mahato"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Approximately 90% of pancreatic cancer (PC) contain KRAS mutations. Mutated KRAS activates the downstream oncogenic PI3K/AKT and MEK signaling pathways and induces drug resistance. However, targeting both pathways with different drugs can al
Externí odkaz:
https://doaj.org/article/15d5f5a7d209467992d3e512b405304b
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1894 (2022)
The incidence of alcoholic liver disease (ALD) is increasing worldwide while no effective treatment has been approved. The progression of ALD has proven to be related to the upregulation of phosphodiesterase 4 (PDE4) expression, and PDE4 inhibitors s
Externí odkaz:
https://doaj.org/article/ccb713bf0ce8483eb59b14f8fd1bff6e
Autor:
Bharti, Sethi, Virender, Kumar, Thilina D, Jayasinghe, Yuxiang, Dong, Donald R, Ronning, Haizhen A, Zhong, Donald W, Coulter, Ram I, Mahato
Publikováno v:
Journal of Controlled Release. 354:80-90
Medulloblastoma (MB) is a malignant pediatric brain tumor which shows upregulation of MYC and sonic hedgehog (SHH) signaling. SHH inhibitor face acquired resistance, which is a major cause of relapse. Further, direct MYC oncogene inhibition is a chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28b08d434f9640b5be15a5d68d7c2dc
https://doi.org/10.1016/j.jconrel.2022.12.055
https://doi.org/10.1016/j.jconrel.2022.12.055
Autor:
Vinod Kumar, Virender Kumar, Amit Kumar Chaudhary, Donald W. Coulter, Timothy McGuire, Ram I. Mahato
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 490-503 (2018)
Medulloblastoma (MB) is a clinically challenging, childhood brain tumor with a diverse genetic makeup and differential miRNA profile. Aiming to identify deregulated miRNAs in MB, the miRNA expression profile of human MB samples was compared to that o
Externí odkaz:
https://doaj.org/article/9ca0d50eeeb24d518ff214bf2e09944d
Autor:
Rajan S, Bhattarai, Jitender, Bariwal, Virender, Kumar, Chen, Hao, Shanshan, Deng, Wei, Li, Ram I, Mahato
Publikováno v:
Journal of Controlled Release. 350:569-583
Microtubule binding agents such as paclitaxel and vincristine have activity in metastatic melanoma. However, even responsive tumors develop resistance, highlighting the need to investigate new drug molecules. Here, we showed that a new compound, CH-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96b100a3112bcb4ba6650e9816d3afc
https://doi.org/10.1016/j.jconrel.2022.08.023
https://doi.org/10.1016/j.jconrel.2022.08.023
Autor:
Vinod Kumar, Amit Kumar Chaudhary, Yuxiang Dong, Haizhen A. Zhong, Goutam Mondal, Feng Lin, Virender Kumar, Ram I. Mahato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Hedgehog (Hh) pathway is involved in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) maintenance resulting in tumor progression. GDC-0449, an inhibitor of Hh pathway component smoothened (Smo) has shown promise in the trea
Externí odkaz:
https://doaj.org/article/bc04897ea06a4b9b92226e9887c43bf1
Figure S1 showed the effect of miR-34a on prostate cancer cell viability. Figure S2 characterized the PEG-PCD polymer. Figure S3 evaluated polymer stability. Figure S4 determined organ toxicity of our formulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdc7b9e42ff54afe037c63c06810046
https://doi.org/10.1158/0008-5472.22413003
https://doi.org/10.1158/0008-5472.22413003
Treatment of prostate cancer with paclitaxel often fails due to the development of chemoresistance caused by downregulation of the tumor suppressor gene miR-34a. In this study, we demonstrate that codelivery of paclitaxel and 2'-hydroxy-2,4,4',5,6'-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea5e85db7a84190038309eb4c33be012
https://doi.org/10.1158/0008-5472.c.6508584.v1
https://doi.org/10.1158/0008-5472.c.6508584.v1
Publikováno v:
Organ Specific Drug Delivery and Targeting to the Lungs ISBN: 9781003182566
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d265f887b7fb9384791f6efac01f7b
https://doi.org/10.1201/9781003182566-19
https://doi.org/10.1201/9781003182566-19
Publikováno v:
Organ Specific Drug Delivery and Targeting to the Lungs ISBN: 9781003182566
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23baf6a875329738eef54d8a785918d
https://doi.org/10.1201/9781003182566-3
https://doi.org/10.1201/9781003182566-3