Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Ram H Nagaraj"'
Autor:
Gretchen A. Johnson, Bindu Kodati, Rooban B. Nahomi, Jennifer H. Pham, Vignesh R. Krishnamoorthy, Nicole R. Phillips, Raghu R. Krishnamoorthy, Ram H. Nagaraj, Dorota L. Stankowska
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in in vitro, in vivo, and ex vivo glaucoma models. Primary retinal ganglion cells (RGCs) were s
Externí odkaz:
https://doaj.org/article/148a954fb5274f399f9f95d3d9dcf236
Autor:
Mi-Hyun Nam, Armaan Dhillon, Rooban B. Nahomi, Noelle L. Carrillo, Clarinda S. Hougen, Ram H. Nagaraj
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionNeurovascular degeneration results in vascular dysfunction, leakage, ischemia, and structural changes that can lead to significant visual impairment. We previously showed the protective effects of peptain-1, a 20 amino acid peptide derive
Externí odkaz:
https://doaj.org/article/1f9de4c7ee714babb492e42c03bb2900
Autor:
Ram H Nagaraj, Alok Kumar Panda, Shilpa Shanthakumar, Puttur Santhoshkumar, NagaRekha Pasupuleti, Benlian Wang, Ashis Biswas
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30257 (2012)
Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modif
Externí odkaz:
https://doaj.org/article/2435bbd880f34e0daada30c99aa26019
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Presbyopia is the progressive loss of the ability of the lens to focus on nearby objects due to its increased stiffness. It occurs in the mid-40s and continues to worsen until the mid-60s. The age-associated increase in protein cross-linking in the l
Externí odkaz:
https://doaj.org/article/5e920941a56f403aa969a84c450ab52a
Autor:
Mi-Hyun Nam, Dorota L. Stankowska, Gretchen A. Johnson, Rooban B. Nahomi, Mina B. Pantcheva, Ram H. Nagaraj
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-10 (2022)
Abstract Ocular hypertension is a significant risk factor for vision loss in glaucoma due to the death of retinal ganglion cells (RGCs). This study investigated the effects of the antiapoptotic peptides peptain-1 and peptain-3a on RGC death in vitro
Externí odkaz:
https://doaj.org/article/152248c07e2f40d1a0894c42eaa6567e
Autor:
Jose-Andres C. Portillo, Amelia Pfaff, Sarah Vos, Matthew Weng, Ram H. Nagaraj, Carlos S. Subauste
Publikováno v:
Cells, Vol 13, Iss 5, p 429 (2024)
CD40 induces pro-inflammatory responses in endothelial and Müller cells and is required for the development of diabetic retinopathy (DR). CD40 is upregulated in these cells in patients with DR. CD40 upregulation is a central feature of CD40-driven i
Externí odkaz:
https://doaj.org/article/497d28e347cd4e8c943649e98d19e1ba
Autor:
Vivian Rajeswaren, Jeffrey O. Wong, Dana Yabroudi, Rooban B. Nahomi, Johanna Rankenberg, Mi-Hyun Nam, Ram H. Nagaraj
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
This review summarizes the latest findings on small heat shock proteins (sHsps) in three major retinal diseases: glaucoma, diabetic retinopathy, and age-related macular degeneration. A general description of the structure and major cellular functions
Externí odkaz:
https://doaj.org/article/7f07f974e8de494d89f5242ff55631d8
Autor:
Sudipta Panja, Rooban B. Nahomi, Johanna Rankenberg, Cole R. Michel, Hanmant Gaikwad, Mi‐Hyun Nam, Ram H. Nagaraj
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a18302e7939d96fbd175c32b458fa7
https://doi.org/10.1111/acel.13797
https://doi.org/10.1111/acel.13797
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2196
Volume 24
Issue 3
Pages: 2196
With aging, human lenses lose the ability to focus on nearby objects due to decreases in accommodative ability, a condition known as presbyopia. An increase in stiffness or decrease in lens elasticity due to protein aggregation and insolubilization a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18730bfc407b5c1ac5ad2e7054f30c33
Autor:
Mi-Hyun Nam, Rooban B. Nahomi, Mina B. Pantcheva, Armaan Dhillon, Vince A. Chiodo, W. Clay Smith, Ram H. Nagaraj
Publikováno v:
Translational vision sciencetechnology. 11(11)
Ocular hypertension is a significant risk factor for vision loss in glaucoma caused by the death of retinal ganglion cells (RGCs). We investigated whether small heat shock proteins (sHsps) expressed in RGCs protect those cells against ocular hyperten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4bf0630fd55214cee02942948916e5
https://pubmed.ncbi.nlm.nih.gov/36355386
https://pubmed.ncbi.nlm.nih.gov/36355386