Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Ram Chandra Gupta"'
Publikováno v:
Arzneimittelforschung. 58:410-418
A sensitive and reproducible high performance liquid chromatography (HPLC)-UV method for the determination of the novel anti-tuberculosis compound 1,2:5,6-di-O-isopropylidene-3-O-(phenyl cyclopropyl methanonyl)-alpha-D-glucofuranose (S-001-14) has be
Autor:
Ram Chandra Gupta, Jawahar Lal
Publikováno v:
Arzneimittelforschung. 58:62-70
CDRI-93/478 (1- [4-(4-fluorophenyl) piperazine-1-yl]-3-(2-oxopyrrolidin-1-yl) propane hydrochloride, an arylpiperazine derivative, is a potent anti-ischemic and anti-hypertensive agent and is in advanced stage of preclinical trials. In order to devel
Publikováno v:
Arzneimittelforschung. 59:21-27
In the present study an accurate and precise HPLC-UV method in rat plasma has been developed and validated for simultaneous determination of S001-281, a new synthetic azulene antiosteoporotic compound, and its sulfoxide metabolite. Separation was ach
Publikováno v:
Arzneimittelforschung. 59:564-570
5-Styryl-4,5-cis-1,3-oxazole-2-one-4-carboxylic acid (CDRI-85/92) is a new proton pump inhibitor presently in advanced stage of preclinical trials as antiulcer pharmacophore. Since proton pump inhibitors are prodrugs requiring activation in acid envi
Publikováno v:
Arzneimittelforschung. 61:120-125
The present study has been designed to investigate the pharmacokinetic parameters of the novel trioxane antimalarial 97-78 (US Patent 6316493 B1, 2001) in male and female rats after single oral and intravenous administration. The pharmacokinetic prof
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:41-48
Objectives This manuscript addresses key pharmacokinetic issues in support of the development of a potent candidate lipid-lowering drug molecule, 16-dehydropregnenolone (DHP). Methods Liquid chromatography-electrospray ionization-tandem mass spectrom
Publikováno v:
European Journal of Pharmaceutical Sciences. 41:312-319
The pharmacokinetic data obtained in lower animals is of considerable importance in drug discovery and development. The objective of the present study was to generate in vitro and in vivo preclinical pharmacokinetic data of 99-357, a synthetic trioxa
Publikováno v:
Chromatographia. 69:1077-1082
The herbal medicament derived from the lipid soluble fraction obtained from Curcuma longa L. (Zingiberaceae) has shown potential neuroprotective activity in disorders like stroke. HM has been standardized with three biomarkers: ar-turmerone, α/β-tu
Publikováno v:
Journal of Chromatography B. 864:52-60
In the present studies, to give momentum to traditionally low throughput pharmacokinetic screening, a bioanalytical method based on the concept of sample pooling for simultaneous bioanalysis of multiple compounds is discussed. A sensitive, selective,
Publikováno v:
Journal of Chromatography B. 842:36-42
A rapid, sensitive, selective and specific HPLC/ESI-MS/MS assay method was developed and validated for the simultaneous quantitation of alpha-/beta-diastereomers of arteether (AE), sulphadoxine (SDX) and pyrimethamine (PYR) in rat blood plasma using