Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ramón Díaz-Trelles"'
Autor:
Ramón Díaz-Trelles, Maria Cecilia Scimia, Paul Bushway, Danh Tran, Anna Monosov, Edward Monosov, Kirk Peterson, Stacey Rentschler, Pedro Cabrales, Pilar Ruiz-Lozano, Mark Mercola
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing respons
Externí odkaz:
https://doaj.org/article/659bd0f4ce584ff8ab4fcf19cbaacd4d
Autor:
Aditi Khandekar, Stephanie C. Hicks, Wei Wang, Stacey Rentschler, Carla J. Weinheimer, Ramón Díaz-Trelles, Steven Springer, Jeanne M. Nerbonne
Publikováno v:
Circulation Research. 119:1324-1338
Rationale: Ventricular arrhythmias often arise from the Purkinje–myocyte junction and are a leading cause of sudden cardiac death. Notch activation reprograms cardiac myocytes to an induced Purkinje-like state characterized by prolonged action pote
Autor:
Ramón Díaz-Trelles, Junko Sawada, Marta Diez-Cuñado, Masanobu Komatsu, Mark Mercola, Qiaozhen Liu, Wenqing Cai, Pilar Ruiz-Lozano, Joseph J. Boyle, Ke Wei, Maria Cecilia Scimia, Bin Zhou
Publikováno v:
Cardiovascular Research. 107:287-294
Aim Age and injury cause structural and functional changes in coronary artery smooth muscle cells (caSMCs) that influence the pathogenesis of coronary artery disease. Although paracrine signalling is widely believed to drive phenotypic changes in caS
Autor:
Jessica Latorre, Ramon Díaz-Trelles, Ferran Comas, Aleix Gavaldà-Navarro, Edward Milbank, Nathalia Dragano, Samantha Morón-Ros, Rajesh Mukthavaram, Francisco Ortega, Anna Castells-Nobau, Núria Oliveras-Cañellas, Wifredo Ricart, Priya P. Karmali, Kiyoshi Tachikawa, Pad Chivukula, Francesc Villarroya, Miguel López, Marta Giralt, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 599-613 (2022)
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering
Externí odkaz:
https://doaj.org/article/2318b693c0cb490ab904a421bf554622
Autor:
Pilar Ruiz-Lozano, Ramón Díaz-Trelles, Danh Tran, Mark Mercola, Kirk L. Peterson, Anna Monosov, Edward Monosov, Paul J. Bushway, Pedro Cabrales, Stacey Rentschler, Maria Cecilia Scimia
Publikováno v:
Nature Communications
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Increasing angiogenesis has long been considered a therapeutic target for improving heart function after injury such as acute myocardial infarction. However, gene, protein and cell therapies to increase microvascularization have not been successful,
Autor:
Carlos G. Perez-Garcia, Ramon Diaz-Trelles, Jerel Boyd Vega, Yanjie Bao, Marciano Sablad, Patty Limphong, Simon Chikamatsu, Hailong Yu, Wendy Taylor, Priya P. Karmali, Kiyoshi Tachikawa, Padmanabh Chivukula
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 87-98 (2022)
Phenylketonuria (PKU) is an inborn error caused by deficiencies in phenylalanine (Phe) metabolism. Mutations in the phenylalanine hydroxylase (PAH) gene are the main cause of the disease whose signature hallmarks of toxically elevated levels of Phe a
Externí odkaz:
https://doaj.org/article/b8a3e32a565741c2a6280ce88d00b19d
Publikováno v:
Neurotoxicity Research. 4:15-23
We have investigated the actions of the H1 receptor antagonist terfenadine on voltage sensitive calcium channels and calcium-mediated pathways. We found that terfenadine prevented N-methyl-D-aspartate (NMDA)-mediated excitotoxicity following stimulat
Autor:
Ramon Diaz-Trelles, Sharon Lee, Kristen Kuakini, Jenny Park, Adrian Dukanovic, Jose A. Gonzalez, Thanhchau Dam, Jae Heon Kim, Jerel Boyd Vega, Marciano Sablad, Priya P. Karmali, Kiyoshi Tachikawa, Padmanabh Chivukula
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 32, Iss , Pp 100882- (2022)
Phenylketonuria (PKU) is a genetic disorder affecting around 1 in 12,000 live births (1), caused by a mutation in the phenylalanine hydroxylase (PAH) gene in the liver which facilitates the catabolism of phenylalanine (Phe). Without a functional copy
Externí odkaz:
https://doaj.org/article/1be292e47d0149edb04f50784cd4065c
Autor:
Ferran Comas, Ramon Díaz-Trelles, Aleix Gavaldà-Navarro, Edward Milbank, Nathalia Dragano, Samantha Morón-Ros, Rajesh Mukthavaram, Jessica Latorre, Francisco Ortega, Maria Arnoriaga-Rodriguez, Núria Oliveras-Cañellas, Wifredo Ricart, Priya P. Karmali, Kiyoshi Tachikawa, Pad Chivukula, Francesc Villarroya, Marta Giralt, Miguel López, José Manuel Fernández-Real, José María Moreno-Navarrete
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 151, Iss , Pp 113156- (2022)
Background and aims: The sexual dimorphism in fat-mass distribution and circulating leptin and insulin levels is well known, influencing the progression of obesity-associated metabolic disease. Here, we aimed to investigate the possible role of lipop
Externí odkaz:
https://doaj.org/article/aa1f1e08da414ca3b75ee9401097de0f
Publikováno v:
Amino acids. 28(2)
Nefopam hydrochloride is a potent non sedative benzoxazocine analgesic that possesses a profile distinct from that of anti-inflammatory drugs. Previous evidence suggested a central action of nefopam but the detailed mechanism remains unclear. We have