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Akademický článek

Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19

Autor: María Ángeles Rodríguez-Hernández, David Carneros, María Núñez-Núñez, Ramón Coca, Rosario Baena, Gema M. López-Ruiz, María Elena Cano-Serrano, Alberto Martínez-Tellería, Ana Fuentes-López, Juan Manuel Praena-Fernandez, Christoph Garbers, José Hernández-Quero, Federico García, Stefan Rose-John, Matilde Bustos

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IL-6 is one of the major mediators of the hyper-inflammatory responses with complex biological functions as it can signal via different modes of action. IL-6 by classical signalling has anti-inflammatory and antibacterial activities, while trans-sign

Externí odkaz: https://doaj.org/article/b07818f2d1a947b48b1f02af608a5c72

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Akademický článek

Inhibition mechanism of the intracellular transporter Ca2+-pump from sarco-endoplasmic reticulum by the antitumor agent dimethyl-celecoxib.

Autor: Ramón Coca, Fernando Soler, Ernesto Cortés-Castell, Vicente Gil-Guillén, Francisco Fernández-Belda

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102083 (2014)

Dimethyl-celecoxib is a celecoxib analog that lacks the capacity as cyclo-oxygenase-2 inhibitor and therefore the life-threatening effects but retains the antineoplastic properties. The action mechanism at the molecular level is unclear. Our in vitro

Externí odkaz: https://doaj.org/article/4e464243c6754553abf2d3b10a6fb66d

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[Usefulness of COVID-19 patients first analysis made at the Emergency Department as a prediction tool for mortality (PMCovid Score).]

Autor: Ana Belén, García-Ruano, Soledad, García-Chileme, Alba, Martínez-Chamorro, Esther, Martínez-Lara, Ramón, Coca-Zúñiga

Publikováno v: Revista espanola de salud publica. 95

The COVID-19 pandemic has generated a high demand for hospital resources taking the national health system to its limit. In order to reduce this over burden and to avoid a potential system collapse, it would be beneficial to generate scientific evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db88246f6c3a2eddb9cb36822e54464a
https://pubmed.ncbi.nlm.nih.gov/34708836

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Bad Prognosis in Critical Ill Patients with COVID‐19 during Short‐Term ICU Stay Regarding Vitamin D Levels

Autor: Ramón Coca-Zúñiga, José Castaño-Pérez, Lourdes Herrera-Quintana, Jorge Molina-López, Juan Francisco Machado-Casas, José Miguel Pérez-Villares, Héctor Vázquez-Lorente, Yenifer Gamarra-Morales, Elena Planells

Publikováno v: Nutrients, Vol 13, Iss 1988, p 1988 (2021)
Nutrients
Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
Volume 13
Issue 6

Background and aims: Vitamin D inadequacy may be involved in the mechanisms of SARS-CoV-2 infection and in potential risk factors for disease propagation or control of coronavirus disease 2019 (COVID-19). This study assessed a short-term evolution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a1e960f624c75015e7e1e4a1e3b50e
http://hdl.handle.net/10481/69603

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Isolated elevation of aspartate aminotransferase (AST) in an asymptomatic patient due to macro-AST

Autor: Eva Martín Salido, Arturo González Raya, Ramón Coca Zúñiga

Publikováno v: Journal of clinical laboratory analysis. 33(2)

Background A rare and benign cause of isolated aspartate aminotransferase (AST) increase is due to the presence of macro aspartate aminotransferase (macro-AST). Macro-AST is not usually considered by clinicians, leading to a large number of unnecessa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7670d091a848a3329865d41a171ab1
https://pubmed.ncbi.nlm.nih.gov/30320474

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Characterization of the palytoxin effect on Ca2+-ATPase from sarcoplasmic reticulum (SERCA)

Autor: Fernando Soler, Ramón Coca, Francisco Fernandez-Belda

Publikováno v: Archives of Biochemistry and Biophysics. 478:36-42

The effect of palytoxin was studied in a microsomal fraction enriched in longitudinal tubules of the sarcoplasmic reticulum membrane. Half-maximal effect of palytoxin on Ca 2+ -ATPase activity yielded an apparent inhibition constant of approx. 0.4 μ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3476b089806733030bc99bb7767c08c
https://doi.org/10.1016/j.abb.2008.07.017

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Inhibition Mechanism of the Intracellular Transporter Ca2+-Pump from Sarco-Endoplasmic Reticulum by the Antitumor Agent Dimethyl-Celecoxib

Autor: Fernando Soler, Vicente Francisco Gil-Guillén, Ramón Coca, Ernesto Cortés-Castell, Francisco Fernandez-Belda

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102083 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a52aa147dd843ee51608a6f4f0143b
https://doi.org/10.1371/journal.pone.0102083

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