Výsledky vyhledávání - "Ramón A Piñol"

Akademický článek

Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.

Autor: Haley S Province, Cuiying Xiao, Allison S Mogul, Ankita Sahoo, Kenneth A Jacobson, Ramón A Piñol, Oksana Gavrilova, Marc L Reitman

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0243986 (2020)

Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A1 receptors (A1AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injec

Externí odkaz: https://doaj.org/article/2443921eeb13429ea8c7ce129986c378

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Akademický článek

Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons.

Autor: Ramón A Piñol, Heather Jameson, Anastas Popratiloff, Norman H Lee, David Mendelowitz

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112138 (2014)

Recent work has shown that oxytocin is involved in more than lactation and uterine contraction. The paraventricular nucleus of the hypothalamus (PVN) contains neuroendocrine neurons that control the release of hormones, including vasopressin and oxyt

Externí odkaz: https://doaj.org/article/5eb4855c80dd471ebb4d1c4d5e8aee13

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A distinct hypothalamus-to-β-cell circuit modulates insulin secretion

Autor: Ioannis Papazoglou, Ji-Hyeon Lee, Zhenzhong Cui, Chia Li, Gianluca Fulgenzi, Young Jae Bahn, Halina M. Staniszewska-Goraczniak, Ramón A. Piñol, Ian B. Hogue, Lynn W. Enquist, Michael J. Krashes, Sushil G. Rane

Publikováno v: Cell Metab

The central nervous system has long been thought to regulate insulin secretion, an essential process in the maintenance of blood glucose levels. However, the anatomical and functional connections between the brain and insulin-producing pancreatic β-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a956541588cab92d164b2a5b42326b
https://europepmc.org/articles/PMC8935365/

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Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure and heart rate, but not food intake

Autor: Vojtěch Škop, Sebastian H. Zahler, Oksana Gavrilova, Ramón A. Piñol, Chia Li, Michael J. Krashes, Brandon K. Tan, Atreyi Saha, Cuiying Xiao, Marc L. Reitman

Publikováno v: Nature neuroscience

Bombesin-like receptor 3 (BRS3) is an orphan G-protein-coupled receptor that regulates energy homeostasis and heart rate. We report that acute activation of Brs3-expressing neurons in the dorsomedial hypothalamus (DMHBrs3) increased body temperature

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9754d3751824d14fa90330f857a5aa38
http://europepmc.org/articles/PMC6203600

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Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors

Autor: Marc L. Reitman, Oksana Gavrilova, Clemence Girardet, Cuiying Xiao, Ramón A. Piñol, Naili Liu, Priyanka Pundir, Andrew A. Butler, Xinzhong Dong, Anna Panyutin, Shalini Jain

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 315:E357-E366

Intraperitoneal administration of the melanocortin agonist melanotan II (MTII) to mice causes a profound, transient hypometabolism/hypothermia. It is preserved in mice lacking any one of melanocortin receptors 1, 3, 4, or 5, suggesting a mechanism in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a3ba4a74f66b58047788bd0b441926
https://doi.org/10.1152/ajpendo.00024.2018

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BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice

Autor: Cuiying Xiao, Ramón A. Piñol, Marc L. Reitman, Naili Liu, Haley S. Province, Oksana Gavrilova

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 36, Iss, Pp-(2020)

Objective Bombesin-like receptor 3 (BRS3) is an orphan receptor and Brs3 knockout mice develop obesity with increased food intake and reduced resting metabolic rate and body temperature. The neuronal populations contributing to these effects were exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367767fa1e1693afd7d3ea271231bb12
https://pubmed.ncbi.nlm.nih.gov/32229422

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Corrigendum to 'Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism' [Mol Metabol 6 (2017) 1540–1550]

Autor: Marc L. Reitman, Cuiying Xiao, Ramón A. Piñol, Cuiling Li, Jesse Lea Carlin, Chu-Xia Deng, Oksana Gavrilova

Publikováno v: Molecular Metabolism, Vol 9, Iss, Pp 220-(2018)
Molecular Metabolism

Objective Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor. Brs3 null mice have reduced resting metabolic rate and body temperature, increased food intake, and obesity. Here we study the role of Brs3 in different neuron types.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccae7acdf0984955ae097f8913deb1d
http://www.sciencedirect.com/science/article/pii/S2212877817310682

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Cool(ing) brain stem GABA neurons

Autor: Marc L. Reitman, Ramón A. Piñol

Publikováno v: Cell Res

Homeostatic control of core body temperature is essential for survival. Temperature is sensed by specific neurons, in turn eliciting both behavioral (i.e., locomotion) and physiologic (i.e., thermogenesis, vasodilatation) responses. Here, we report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c2f2260003e69ff1d3ce77357817f6
https://doi.org/10.1038/s41422-019-0223-y

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