Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ramón A Lorca"'
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182068 (2017)
Large conductance voltage- and Ca2+-activated K+ (BKCa) channels are essential regulators of membrane excitability in a wide variety of cells and tissues. An important mechanism of modulation of BKCa channel activity is its association with auxiliary
Externí odkaz:
https://doaj.org/article/427cc5f1ca9f4b58986aeb5197d6a949
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The large-conductance voltage- and Ca2+-activated K+ channel (BKCa) is an important regulator of membrane excitability in a wide variety of cells and tissues. In myometrial smooth muscle, activation of BKCa plays essential roles in buffering contract
Externí odkaz:
https://doaj.org/article/225878cd6ba74775999f2ee0f6c0f6d9
Autor:
Amanda K. Jones, Paul J. Rozance, Laura D. Brown, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Sean W. Limesand, Stephanie R. Wesolowski
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract Gestational hypoxemia is often associated with reduced birth weight, yet how hypoxemia controls uteroplacental nutrient metabolism and supply to the fetus is unclear. This study tested the effects of maternal hypoxemia (HOX) between 0.8 and
Externí odkaz:
https://doaj.org/article/6d39b3d4d081446c8544893989d2a34f
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(5)
In healthy near-term women, blood flow to the uteroplacental circulation is estimated as 841 mL/min, which is greater than in other mammalian species. We argue that as uterine venous Po2 sets the upper limit for O2 diffusion to the fetus, high uterin
Autor:
Rachael Bok, Damian D. Guerra, Ramón A. Lorca, Sara A. Wennersten, Peter S. Harris, Abhishek K. Rauniyar, Sally P. Stabler, Kenneth N. MacLean, James R. Roede, Laura D. Brown, K. Joseph Hurt
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101827- (2021)
During pregnancy, estrogen (E2) stimulates uterine artery blood flow (UBF) by enhancing nitric oxide (NO)-dependent vasodilation. Cystathionine γ-lyase (CSE) promotes vascular NO signaling by producing hydrogen sulfide (H2S) and by maintaining the r
Externí odkaz:
https://doaj.org/article/4ba24169c8a14e86b9c9066e884fb457
Autor:
Hannah M. Kyllo, Dong Wang, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Randall B. Wilkening, Paul J. Rozance, Laura D. Brown, Stephanie R. Wesolowski
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Glucose, lactate, and amino acids are major fetal nutrients. During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained yet fetal glucose and amino acid sup
Autor:
Sahand Fallahi, Julie A. Houck, Anna G. Euser, Colleen G. Julian, Lorna G. Moore, Ramón A. Lorca
Publikováno v:
The Journal of physiologyReferences. 600(24)
High-altitude (2500 m or 8200 ft) residence reduces uterine artery blood flow during pregnancy, contributing to an increased incidence of preeclampsia and intrauterine growth restriction. However, not all pregnancies are affected by the chronic hypox
Autor:
Lorna G. Moore, Anna G. Euser, Katharine K. Nelson, Kori Baker, Colleen G. Julian, Julie A. Houck, Ramón A. Lorca, Louise C. Laurent, Christopher J. Matarazzo, Elise S. Bales, Mana M. Parast, Mariko Horii
Publikováno v:
Placenta. 104:267-276
Introduction High-altitude (>2500 m) residence augments the risk of intrauterine growth restriction (IUGR) and preeclampsia likely due, in part, to uteroplacental hypoperfusion. Previous genomic and transcriptomic studies in humans and functional stu
Autor:
Ramón A. Lorca, Lorna G. Moore, Colleen G. Julian, Julie A. Houck, Sydney L. Lane, Elise S. Bales, Alexandrea S. Doyle
Publikováno v:
J Physiol
KEY POINTS Pregnancy at high altitude is associated with a greater incidence of fetal growth restriction due, in part, to lesser uterine artery blood flow. AMP-activated protein kinase (AMPK) activation vasodilates arteries and may increase uterine a
Autor:
Elise S. Bales, Christopher J. Matarazzo, David J. Orlicky, Lorna G. Moore, Ramón A. Lorca, Julie A. Houck, Anna G. Euser, Colleen G. Julian
Publikováno v:
Am J Physiol Heart Circ Physiol
High-altitude (>2,500 m) residence increases the incidence of intrauterine growth restriction (IUGR) due, in part, to reduced uterine artery blood flow and impaired myometrial artery (MA) vasodilator response. A role for the AMP-activated protein kin