Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation.

Autor: Black EM; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA., Ramírez Parrado CA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA., Trier I; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA., Li W; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA.; Department of Pharmacology, Yale University, New Haven, CT, 06511, USA., Joo YK; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA., Pichurin J; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA., Liu Y; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA.; Department of Pharmacology, Yale University, New Haven, CT, 06511, USA., Kabeche L; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA. Lilian.kabeche@yale.edu.; Yale Cancer Biology Institute, Yale University, West Haven, CT, 06516, USA. Lilian.kabeche@yale.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Dec 30; Vol. 15 (1), pp. 10782. Date of Electronic Publication: 2024 Dec 30.