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of 33
pro vyhledávání: '"Ralphiel S. Payne"'
Cariprazine delays ouabain-evoked epileptiform spikes and loss of activity in rat hippocampal slices
Autor:
Bela Kiss, Avital Schurr, Istvan Gyertyan, Ralphiel S. Payne, Nika Adham, Yonglin Gao, Rif S. El-Mallakh, Zhemin Lei
Publikováno v:
Psychiatry Research. 229:370-373
In the only bipolar cycling in vitro model, rat hippocampal slices are treated with the sodium pump inhibitor ouabain, which induces epileptiform activity, followed by refractory activity loss that recovers and cycles back to epileptiform activity. T
Autor:
Ralphiel S. Payne, Avital Schurr
Publikováno v:
Journal of Neurochemistry. 81:108-111
The glucose paradox of cerebral ischemia, the aggravation of delayed neuronal damage by preischemic hyperglycemia, is a well-documented phenomenon. Recently, we demonstrated that corticosterone (CT) plasma levels were significantly elevated within 30
Autor:
Ralphiel S. Payne, Avital Schurr
Publikováno v:
Neuroscience Letters. 424:111-115
We previously reported that acute exposure of rat hippocampal brain slices to stress levels of corticosterone aggravated ischemic neuronal damage. The present study examined whether or not an acute stress level corticosterone exposure interferes with
Publikováno v:
Brain Research. 1021:76-81
In the present study we tested the ability of the inhalation anesthetic sevoflurane to induce preconditioning against hypoxia in vitro. Rat hippocampal slices were prepared using established procedures. After 90 min of incubation, slices were exposed
Publikováno v:
Brain Research. 971:9-17
Aggravation of neuronal damage by preischemic hyperglycemia, i.e. the glucose paradox of cerebral ischemia, is a well-established phenomenon that has prompted clinicians around the world to closely monitor and control blood glucose levels in surgical
Autor:
Zixi Jack Cheng, David Gozal, Kenneth R. Brittian, Evelyne Gozal, Barry W. Row, Aviv Goldbart, Leila Kheirandish, Shang-Z. Guo, Ralphiel S. Payne, Avital Schurr
Publikováno v:
Neuroscience. 122:585-590
Intermittent hypoxia (IH) during sleep, a characteristic feature of sleep-disordered breathing (SDB) is associated with time-dependent apoptosis and spatial learning deficits in the adult rat. The mechanisms underlying such neurocognitive deficits re
Publikováno v:
Neuroscience Letters. 308:29-32
Cardiac arrest and resuscitation were used to induce brain damage and susceptibility to sound-triggered seizures in Sprague-Dawley rats. Glucose preloading was used to vary seizure susceptibility. Because loop diuretics can block these seizures, we i
Publikováno v:
Neuroscience Letters. 307:151-154
Ischemic preconditioning (PC) of heart and brain is a well-documented phenomenon. However, the mechanism underlying the increased resistance to severe ischemia by a preceding mild ischemic exposure remains unclear. Over a decade ago, we demonstrated
Publikováno v:
Journal of Neuroscience Research. 66:782-789
Aerobic lactate utilization is crucial for recovery of neuronal function posthypoxia in vitro. In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models. First, the glucose paradox of cerebral ischemia, namely,
Publikováno v:
Methods. 18:117-126
This article describes methods and experimental paradigms used in combination with the rat hippocampal slice preparation in an attempt to better understand cerebral energy metabolism under the following conditions: normal resting conditions, conditio