Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ralph de Vere White"'
Autor:
Sisi Wang, Hongyong Zhang, Tiffany M Scharadin, Maike Zimmermann, Bin Hu, Amy Wang Pan, Ruth Vinall, Tzu-yin Lin, George Cimino, Patrick Chain, Momchilo Vuyisich, Cheryl Gleasner, Kim Mcmurry, Michael Malfatti, Kenneth Turteltaub, Ralph de Vere White, Chong-xian Pan, Paul T Henderson
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146256 (2016)
We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying platinum drug resistance. The 5637 human bladder cancer cell line was cultured over ten months wi
Externí odkaz:
https://doaj.org/article/7da959f3a8c145ec8b8b5c87c4f25fd0
Autor:
Paul T. Henderson, Chong-xian Pan, Ralph de Vere White, Karim Chamie, Alexandra Drakaki, Clifford G. Tepper, George D. Cimino, Kenneth W. Turteltaub, Susan Airhart, Hongyuan Yang, Ted Ognibene, Kurt Haack, Michael Malfatti, Tzu-yin Lin, Hongyong Zhang, Si-Si Wang, Maike Zimmermann
We report progress on predicting tumor response to platinum-based chemotherapy with a novel mass spectrometry approach. Fourteen bladder cancer patients were administered one diagnostic microdose each of [14C]carboplatin (1% of the therapeutic dose).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecee25af3630876e71d2c645bb27963
https://doi.org/10.1158/1535-7163.c.6537576
https://doi.org/10.1158/1535-7163.c.6537576
Autor:
Paul T. Henderson, Chong-xian Pan, Ralph de Vere White, Karim Chamie, Alexandra Drakaki, Clifford G. Tepper, George D. Cimino, Kenneth W. Turteltaub, Susan Airhart, Hongyuan Yang, Ted Ognibene, Kurt Haack, Michael Malfatti, Tzu-yin Lin, Hongyong Zhang, Si-Si Wang, Maike Zimmermann
Chemical structures, patient data, mouse survival curves, additional biomarker data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2764d3d1fe8d481eae79211b415ae1fa
https://doi.org/10.1158/1535-7163.22503975.v1
https://doi.org/10.1158/1535-7163.22503975.v1
Autor:
Tzu-yin Lin, Chong-Xian Pan, Zhixiu Cao, Guru Sonpavde, Ai Hong Ma, Ralph de Vere White, Jianming Guo, Qilai Long, Hongyong Zhang, Roger Xia
Publikováno v:
Cancer Immunol Immunother
BACKGROUND: Perturbation of the CDK4/6 pathway is frequently observed in advanced bladder cancer. We investigated the potential of targeting this pathway alone or in combination with chemotherapy or immunotherapy as a therapeutic approach for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d45dcabf6da447f78c32f916939496
https://doi.org/10.1007/s00262-020-02609-5
https://doi.org/10.1007/s00262-020-02609-5
Publikováno v:
Journal of Clinical Oncology. 38:1760-1762
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5612604ee7a9de69995eb9999252725
https://doi.org/10.1200/jco.19.01731
https://doi.org/10.1200/jco.19.01731
Autor:
S. Wang, Tzu-yin Lin, Maike Zimmermann, Chong-Xian Pan, Ralph de Vere White, Kurt W. Haack, Michael A. Malfatti, Hongyong Zhang, Paul T. Henderson, Kenneth W. Turteltaub, George D. Cimino
Publikováno v:
International Journal of Cancer. 141:604-613
The platinum-based drugs cisplatin, carboplatin and oxaliplatin are often used for chemotherapy, but drug resistance is common. The prediction of resistance to these drugs via genomics is a challenging problem since hundreds of genes are involved. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cff88cff22f04b3f06d9d756cfa53be7
https://doi.org/10.1002/ijc.30747
https://doi.org/10.1002/ijc.30747
Autor:
Sisi Wang, Paul T. Henderson, Michael A. Malfatti, Maike Zimmermann, Ralph de Vere White, Kenneth W. Turteltaub, Chong-Xian Pan, Tiffany M. Scharadin
Platinum drugs, including carboplatin and oxaliplatin, are commonly used chemotherapy drugs that kill cancer cells by forming toxic drug-DNA adducts. These drugs have a proven, but modest, efficacy against several aggressive subtypes of breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a0ad32218430814d4a0f57d37d3e80
https://europepmc.org/articles/PMC6538392/
https://europepmc.org/articles/PMC6538392/
Autor:
Andreas M. Heilmann, Rachel L. Erlich, Mamta Parikh, Siraj M. Ali, Chong-Xian Pan, Philip J. Stephens, Vincent A. Miller, Jeffrey S. Ross, Alexa B. Schrock, Regina F Gandour-Edwards, John Douglas Mcpherson, Julia A. Elvin, Primo N. Lara, Ralph de Vere White, Christopher P. Evans
Publikováno v:
Lara, PN; Heilmann, AM; Elvin, JA; Parikh, M; de Vere White, R; Gandour-Edwards, R; et al.(2017). TMPRSS2-ERG fusions unexpectedly identified in men initially diagnosed with nonprostatic malignancies.. JCO precision oncology, 2017. doi: 10.1200/po.17.00065. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3mh4w1gt
JCO precision oncology, vol 2017, iss 1
JCO precision oncology, vol 2017, iss 1
Purpose TMPRSS2-ERG gene fusions are frequently found in prostate cancer and are pathognomonic for prostatic origin. In a series of cancer cases assayed with comprehensive genomic profiling (CGP) in the course of clinical care, we reviewed the freque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e6f4c8bfa0440ab4aa815ffb1ac818
http://www.escholarship.org/uc/item/3mh4w1gt
http://www.escholarship.org/uc/item/3mh4w1gt
Autor:
Wei He, Aimy Sebastian, Nicholas R. Hum, Ralph de Vere White, Gabriela G. Loots, Chong-Xian Pan, Paramita M. Ghosh, Kelly A. Martin, Salma Siddiqui
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 20
International journal of molecular sciences, vol 20, iss 20
International Journal of Molecular Sciences, Vol 20, Iss 20, p 4983 (2019)
Volume 20
Issue 20
International journal of molecular sciences, vol 20, iss 20
International Journal of Molecular Sciences, Vol 20, Iss 20, p 4983 (2019)
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9404def051d914513e8994d2db59c955
https://doi.org/10.3390/ijms20204983
https://doi.org/10.3390/ijms20204983
Autor:
Maike Zimmermann, Michael A. Malfatti, Chong-Xian Pan, Hongyong Zhang, Paul T. Henderson, Ralph de Vere White, Tiffany M. Scharadin, George D. Cimino, Kenneth W. Turteltaub, Sisi Wang
Publikováno v:
Chemical research in toxicology, vol 29, iss 11
Gemcitabine metabolites cause termination of DNA replication and induction of apoptosis. We determined whether subtherapeutic “microdoses” of gemcitabine are incorporated into DNA at levels that correlate to drug cytotoxicity. A pair of nearly is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b961fd02e6d63476aedb25ea317d4db
https://escholarship.org/uc/item/9348h14s
https://escholarship.org/uc/item/9348h14s