Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ralph W.H. Gottschalk"'
Autor:
Manon van Engeland, Matty P. Weijenberg, Piet A. van den Brandt, Royle A. Goldbohm, Adriaan P. de Bruïne, Anton F.P.M. de Goeij, Frederik J. van Schooten, Ralph W.H. Gottschalk, Kim A.D. Wouters, Stefan de Vogel
Supplementary Table 1 from Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2537d2a0a5133dd84fbf4e1c5fe32c
https://doi.org/10.1158/1055-9965.22435704.v1
https://doi.org/10.1158/1055-9965.22435704.v1
Autor:
Manon van Engeland, Matty P. Weijenberg, Piet A. van den Brandt, Royle A. Goldbohm, Adriaan P. de Bruïne, Anton F.P.M. de Goeij, Frederik J. van Schooten, Ralph W.H. Gottschalk, Kim A.D. Wouters, Stefan de Vogel
Aberrant DNA methylation affects carcinogenesis of colorectal cancer. Folate metabolizing enzymes may influence the bioavailability of methyl groups, whereas DNA and histone methyltransferases are involved in epigenetic regulation of gene expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4360b025ceaa66bab17c814a4fec9bbf
https://doi.org/10.1158/1055-9965.c.6515058
https://doi.org/10.1158/1055-9965.c.6515058
Autor:
Jörgen Bierau, Kees Schoonderwoerd, Hubert J.M. Smeets, Alexandra T.M. Hendrickx, Debby M.E.I. Hellebrekers, Ralph W.H. Gottschalk, Janneke G J Hoeijmakers, Suzanne C E H Sallevelt, Daphna D. J. Habets, Tom E. J. Theunissen
Publikováno v:
European Journal of Human Genetics, 25(7), 886-888. Nature Publishing Group
In a 51-year-old patient of consanguineous parents with a severe neuromuscular phenotype of early-onset ataxia, myoclonia, dysarthria, muscle weakness and exercise intolerance, exome sequencing revealed a novel homozygous variant (c.-264-31delinsCTCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aec9e72ef66dff36ac6844c1447eab
https://doi.org/10.1038/ejhg.2017.62
https://doi.org/10.1038/ejhg.2017.62
Autor:
Leo J. Schouten, Marjolein H.F.M. Lentjes, Hubert J.M. Smeets, Matty P. Weijenberg, Piet A. van den Brandt, Colinda C. J. M. Simons, Ralph W.H. Gottschalk, A.M. Voets, Manon van Engeland, Frits H.M. van Osch
Publikováno v:
Carcinogenesis, 36(12), 1502-1510. Oxford University Press
Low mitochondrial DNA (mtDNA) copy number in tumors has been associated with worse prognosis in colorectal cancer (CRC). This study further deciphers the role of mtDNA copy number in CRC by comparing mtDNA copy number between healthy, adenoma and car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4200e6965c555cf2653326cbb8143
https://cris.maastrichtuniversity.nl/en/publications/abf71387-e597-4df4-a0bf-db060283d4eb
https://cris.maastrichtuniversity.nl/en/publications/abf71387-e597-4df4-a0bf-db060283d4eb
Autor:
Henk Van Loveren, Jos C. S. Kleinjans, J.H.M. van Delft, Unni Cecilie Nygaard, Martinus Løvik, D.M. van Leeuwen, Berit Granum, Ralph W.H. Gottschalk, Ellen Namork, Solvor B. Stølevik, Hans Gmuender, Kevin Hochstenbach, Helle Margrete Meltzer
Publikováno v:
Toxicological Sciences, 129(2), 315-324. Oxford University Press
A crucial period for the development of the immune system occurs in utero. This results in a high fetal vulnerability to immunotoxic exposure, and indeed, immunotoxic effects have been reported, demonstrating negative effects on immune-related health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18167f27fb21c0dfb0762ed3f7b3aa55
https://doi.org/10.1093/toxsci/kfs214
https://doi.org/10.1093/toxsci/kfs214
Autor:
J.H.M. van Delft, Kevin Hochstenbach, D.M. van Leeuwen, Martinus Løvik, Ralph W.H. Gottschalk, Berit Granum, H. van Loveren, Ellen Namork, Solvor B. Stølevik, Hans Gmuender, Unni Cecilie Nygaard
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 746(2), 124-134. Elsevier
a b s t r a c t For evaluating genotoxic exposure in human populations a number of biomarkers has been successfully applied over the last 30 years to determine early biological effects due to exposure to carcinogens. Despite their success, these earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d175a6961d02d95db06fdfda0fd179
https://doi.org/10.1016/j.mrgentox.2012.01.002
https://doi.org/10.1016/j.mrgentox.2012.01.002
Autor:
P.A. van den Brandt, Ralph W.H. Gottschalk, Matty P. Weijenberg, A.F.P.M. de Goeij, Kim A.D. Wouters, F.J. van Schooten, R.A. Goldbohm, M. van Engeland, Brenda Bongaerts
Publikováno v:
Alcohol, 45(3), 217-225. Elsevier Inc.
Within the Netherlands Cohort Study (1986), we examined associations between alcohol consumption, the alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer (CRC). After a follow-up period of 7.3 years, 594 CRC cases with informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df0560440ecf4973e93f744e72b538e
https://doi.org/10.1016/j.alcohol.2010.10.003
https://doi.org/10.1016/j.alcohol.2010.10.003
Autor:
Ralph W.H. Gottschalk, Matty P. Weijenberg, Adriaan P. de Bruïne, Frederik J. van Schooten, R. Alexandra Goldbohm, Manon van Engeland, Kim A.D. Wouters, Stefan de Vogel, Piet A. van den Brandt, Anton F.P.M. de Goeij
Publikováno v:
Cancer Causes and Control, 1, 22, 1-12
Cancer Causes & Control, 22(1), 1-12. Springer, Cham
Cancer Causes & Control
Cancer Causes & Control, 22(1), 1-12. Springer, Cham
Cancer Causes & Control
Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ff4713ea1cc6b3591ce50827318c73
https://doi.org/10.1007/s10552-010-9659-6
https://doi.org/10.1007/s10552-010-9659-6
Autor:
Jos C. S. Kleinjans, Marcel H. M. van Herwijnen, Ralph W.H. Gottschalk, Karen Mathijs, André Boorsma, Joost H.M. van Delft, Danyel Jennen, Karen Brauers
Publikováno v:
Toxicological Sciences, 112(2), 374-384. Oxford University Press
Assessing the potential carcinogenicity of chemicals for humans represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk at only limited reliability and are simultaneously expensive and long lasting. In order to seek for al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d692dea33c122541032a8a15d1b9d8e
https://doi.org/10.1093/toxsci/kfp229
https://doi.org/10.1093/toxsci/kfp229
Autor:
Ralph W.H. Gottschalk, André Boorsma, Anne S. Kienhuis, Jos C. S. Kleinjans, Marcel H. M. van Herwijnen, Joost H.M. van Delft, Cornelis H. C. Dejong, Marcel C. G. van de Poll, Rob H. Stierum
Publikováno v:
Toxicology in Vitro, 23(6), 1163-1169. Elsevier Science
A compound for which marked species differences have been reported in laboratory animals and humans is coumarin. In rats, metabolites of coumarin are highly toxic, whereas in humans, the compound is mainly metabolized to non-toxic metabolites. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8182974ede9516c03d7e0fe10ef51dd9
https://doi.org/10.1016/j.tiv.2009.06.005
https://doi.org/10.1016/j.tiv.2009.06.005