Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Ralph V Shohet"'
Autor:
Katie C. Y. Lee, Allison L. Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V. Shohet
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main
Externí odkaz:
https://doaj.org/article/dc9c299e2c4b491ba0c24aeda1e93493
Autor:
Angel A Yanagihara, Ralph V Shohet
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51368 (2012)
Chironex fleckeri (Australian box jellyfish) stings can cause acute cardiovascular collapse and death. We developed methods to recover venom with high specific activity, and evaluated the effects of both total venom and constituent porins at doses eq
Externí odkaz:
https://doaj.org/article/558e8c4f1da14ac18656b2fdfb5c9d55
Autor:
Christy L Avery, Praveen Sethupathy, Steven Buyske, Qianchuan He, Dan-Yu Lin, Dan E Arking, Cara L Carty, David Duggan, Megan D Fesinmeyer, Lucia A Hindorff, Janina M Jeff, Liviu Klein, Kristen K Patton, Ulrike Peters, Ralph V Shohet, Nona Sotoodehnia, Alicia M Young, Charles Kooperberg, Christopher A Haiman, Karen L Mohlke, Eric A Whitsel, Kari E North
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002870 (2012)
The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Am
Externí odkaz:
https://doaj.org/article/1ef7f714f0d94f5a84cdac1eaf2428c0
Autor:
Logan Dumitrescu, Cara L Carty, Kira Taylor, Fredrick R Schumacher, Lucia A Hindorff, José L Ambite, Garnet Anderson, Lyle G Best, Kristin Brown-Gentry, Petra Bůžková, Christopher S Carlson, Barbara Cochran, Shelley A Cole, Richard B Devereux, Dave Duggan, Charles B Eaton, Myriam Fornage, Nora Franceschini, Jeff Haessler, Barbara V Howard, Karen C Johnson, Sandra Laston, Laurence N Kolonel, Elisa T Lee, Jean W MacCluer, Teri A Manolio, Sarah A Pendergrass, Miguel Quibrera, Ralph V Shohet, Lynne R Wilkens, Christopher A Haiman, Loïc Le Marchand, Steven Buyske, Charles Kooperberg, Kari E North, Dana C Crawford
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002138 (2011)
For the past five years, genome-wide association studies (GWAS) have identified hundreds of common variants associated with human diseases and traits, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)
Externí odkaz:
https://doaj.org/article/68c7d03785fd492ab45f2b112beb3801
Autor:
Raffi Bekeredjian, Chad B Walton, Keith A MacCannell, Jennifer Ecker, Fred Kruse, Joel T Outten, David Sutcliffe, Robert D Gerard, Richard K Bruick, Ralph V Shohet
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11693 (2010)
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1a
Externí odkaz:
https://doaj.org/article/ddb8e55358564cacb40386e4a6b5b22b
Autor:
Cynthia D. Anderson, Jennifer Ataam Arthur, Yuan Zhang, Nike Bharucha, Ioannis Karakikes, Ralph V. Shohet
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 733-737 (2023)
CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns,
Externí odkaz:
https://doaj.org/article/cd4e3d92fb3e4e40a56c6c448a20b441
Autor:
Sara B. Stephens, Sherene Shalhub, Nicholas Dodd, Jesse Li, Michael Huang, Seitaro Oda, Kalyan Kancherla, Tam T. Doan, Siddharth K. Prakash, Justin D. Weigand, Federico M. Asch, Taylor Beecroft, Alana Cecchi, Teniola Shittu, Liliana Preiss, Scott A. LeMaire, Richard B. Devereux, Reed E. Pyeritz, Kathryn W. Holmes, Mary J. Roman, Ronald V. Lacro, Ralph V. Shohet, Rajesh Krishnamurthy, Kim Eagle, Peter Byers, Dianna M. Milewicz, Shaine A. Morris
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Arterial tortuosity is associated with adverse events in Marfan and Loeys‐Dietz syndromes but remains understudied in Vascular Ehlers‐Danlos syndrome. Methods and Results Subjects with a pathogenic COL3A1 variant diagnosed at age
Externí odkaz:
https://doaj.org/article/baafb229fe084535a00ef7c97ecf8d3c
Autor:
Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1091-H1107
Many anticancer therapies cause serious cardiovascular complications that degrade quality of life and cause early mortality in treated patients. Specifically, doxorubicin is known as an effective anticancer agent that causes cardiomyopathy in treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff466cb4ae20745d322bd364d2bd9ab0
https://doi.org/10.1152/ajpheart.00312.2022
https://doi.org/10.1152/ajpheart.00312.2022
Autor:
Kathryn W. Holmes, Sheila Markwardt, Kim A. Eagle, Richard B. Devereux, Jonathan W. Weinsaft, Federico M. Asch, Scott A. LeMaire, Cheryl L. Maslen, Howard K. Song, Dianna M. Milewicz, Siddharth K. Prakash, Dongchuan Guo, Shaine A. Morris, Reed E. Pyeritz, Rita C. Milewski, William J. Ravekes, H.C. Dietz, Ralph V. Shohet, Michael Silberbach, Mary J. Roman
Publikováno v:
Journal of the American College of Cardiology. 79:2069-2081
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78207642ebc84a917077be3a8e206737
https://doi.org/10.1016/j.jacc.2022.03.367
https://doi.org/10.1016/j.jacc.2022.03.367
Appropriate gene expression within cardiomyocytes is coordinated by chromatin factors and is essential for heart function. We investigated the role of the chromatin reader ZMYND8 in the mouse heart using null and conditional knockouts (Zmynd8-cKO). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::496efaffc68453687120355c10d11a98
https://doi.org/10.1101/2022.10.06.510015
https://doi.org/10.1101/2022.10.06.510015
