Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Ralph V Shohet"'
Autor:
Katie C. Y. Lee, Allison L. Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V. Shohet
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main
Externí odkaz:
https://doaj.org/article/dc9c299e2c4b491ba0c24aeda1e93493
Autor:
Cynthia D. Anderson, Jennifer Ataam Arthur, Yuan Zhang, Nike Bharucha, Ioannis Karakikes, Ralph V. Shohet
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 733-737 (2023)
CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns,
Externí odkaz:
https://doaj.org/article/cd4e3d92fb3e4e40a56c6c448a20b441
Autor:
Sara B. Stephens, Sherene Shalhub, Nicholas Dodd, Jesse Li, Michael Huang, Seitaro Oda, Kalyan Kancherla, Tam T. Doan, Siddharth K. Prakash, Justin D. Weigand, Federico M. Asch, Taylor Beecroft, Alana Cecchi, Teniola Shittu, Liliana Preiss, Scott A. LeMaire, Richard B. Devereux, Reed E. Pyeritz, Kathryn W. Holmes, Mary J. Roman, Ronald V. Lacro, Ralph V. Shohet, Rajesh Krishnamurthy, Kim Eagle, Peter Byers, Dianna M. Milewicz, Shaine A. Morris
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Arterial tortuosity is associated with adverse events in Marfan and Loeys‐Dietz syndromes but remains understudied in Vascular Ehlers‐Danlos syndrome. Methods and Results Subjects with a pathogenic COL3A1 variant diagnosed at age
Externí odkaz:
https://doaj.org/article/baafb229fe084535a00ef7c97ecf8d3c
Autor:
Allison Lesher Williams, Chad B. Walton, Blake Pinell, Vedbar S. Khadka, Brandyn Dunn, Katie Lee, M. C. Therese Anagaran, Abigail Avelar, Ralph V. Shohet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Ischemic heart disease is a leading cause of heart failure and hypoxia inducible factor 1 (HIF1) is a key transcription factor in the response to hypoxic injury. Our lab has developed a mouse model in which a mutated, oxygen-stable form of H
Externí odkaz:
https://doaj.org/article/3358c57a1c804a2fa84edf3e2217d1eb
Autor:
Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1091-H1107
Many anticancer therapies cause serious cardiovascular complications that degrade quality of life and cause early mortality in treated patients. Specifically, doxorubicin is known as an effective anticancer agent that causes cardiomyopathy in treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff466cb4ae20745d322bd364d2bd9ab0
https://doi.org/10.1152/ajpheart.00312.2022
https://doi.org/10.1152/ajpheart.00312.2022
Autor:
Lauren L. Ching, Vivek R. Nerurkar, Eunjung Lim, Ralph V. Shohet, Marian E. Melish, Andras Bratincsak
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
Kawasaki disease (KD) is the leading cause of acquired pediatric heart disease in the developed world as 25–30% of untreated patients and at least 5% of treated patients will develop irreversible coronary artery lesions (CAL). Pentraxin-3 (PTX-3) h
Externí odkaz:
https://doaj.org/article/a973034ec53d4f6c87460e2a14973a90
Publikováno v:
Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract In this study, we created a mouse model of methamphetamine cardiomyopathy that reproduces the chronic, progressive dosing commonly encountered in addicted subjects. We gradually increased the quantity of methamphetamine given to C57Bl/6 mice
Externí odkaz:
https://doaj.org/article/8e0952af452842b0bf87260cce748489
Autor:
Kathryn W. Holmes, Sheila Markwardt, Kim A. Eagle, Richard B. Devereux, Jonathan W. Weinsaft, Federico M. Asch, Scott A. LeMaire, Cheryl L. Maslen, Howard K. Song, Dianna M. Milewicz, Siddharth K. Prakash, Dongchuan Guo, Shaine A. Morris, Reed E. Pyeritz, Rita C. Milewski, William J. Ravekes, H.C. Dietz, Ralph V. Shohet, Michael Silberbach, Mary J. Roman
Publikováno v:
Journal of the American College of Cardiology. 79:2069-2081
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78207642ebc84a917077be3a8e206737
https://doi.org/10.1016/j.jacc.2022.03.367
https://doi.org/10.1016/j.jacc.2022.03.367
Appropriate gene expression within cardiomyocytes is coordinated by chromatin factors and is essential for heart function. We investigated the role of the chromatin reader ZMYND8 in the mouse heart using null and conditional knockouts (Zmynd8-cKO). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::496efaffc68453687120355c10d11a98
https://doi.org/10.1101/2022.10.06.510015
https://doi.org/10.1101/2022.10.06.510015
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70fa61912a37c69199411f2ac3259cfc
https://doi.org/10.1096/fasebj.2022.36.s1.0r496
https://doi.org/10.1096/fasebj.2022.36.s1.0r496