Zobrazeno 1 - 10
of 5 799
pro vyhledávání: '"Ralph V"'
Autor:
Katie C. Y. Lee, Allison L. Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V. Shohet
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main
Externí odkaz:
https://doaj.org/article/dc9c299e2c4b491ba0c24aeda1e93493
Autor:
Ralph V. Chamberlin, Stuart M. Lindsay
Publikováno v:
Nanomaterials, Vol 14, Iss 22, p 1828 (2024)
Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review, it is emphasized that extending ideas from nanothermodynamics to simplistic m
Externí odkaz:
https://doaj.org/article/c27a21f18e79487bb64d44924735379c
Autor:
Cynthia D. Anderson, Jennifer Ataam Arthur, Yuan Zhang, Nike Bharucha, Ioannis Karakikes, Ralph V. Shohet
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 733-737 (2023)
CRISPR-Cas9-based genome editing technologies, such as base editing, have the potential for clinical translation, but delivering nucleic acids into target cells in vivo is a major obstacle. Viral vectors are widely used but come with safety concerns,
Externí odkaz:
https://doaj.org/article/cd4e3d92fb3e4e40a56c6c448a20b441
Autor:
Yi X. Wu, Eric J. Choi, Amberly A. Vu, Pengbo Jiang, Sohrab N. Ali, Roshan M. Patel, Jaime Landman, Ralph V. Clayman
Publikováno v:
ACS Omega, Vol 8, Iss 32, Pp 29003-29011 (2023)
Externí odkaz:
https://doaj.org/article/af2c26444738403f992c7beb7adbd1b6
Autor:
Sara B. Stephens, Sherene Shalhub, Nicholas Dodd, Jesse Li, Michael Huang, Seitaro Oda, Kalyan Kancherla, Tam T. Doan, Siddharth K. Prakash, Justin D. Weigand, Federico M. Asch, Taylor Beecroft, Alana Cecchi, Teniola Shittu, Liliana Preiss, Scott A. LeMaire, Richard B. Devereux, Reed E. Pyeritz, Kathryn W. Holmes, Mary J. Roman, Ronald V. Lacro, Ralph V. Shohet, Rajesh Krishnamurthy, Kim Eagle, Peter Byers, Dianna M. Milewicz, Shaine A. Morris
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Arterial tortuosity is associated with adverse events in Marfan and Loeys‐Dietz syndromes but remains understudied in Vascular Ehlers‐Danlos syndrome. Methods and Results Subjects with a pathogenic COL3A1 variant diagnosed at age
Externí odkaz:
https://doaj.org/article/baafb229fe084535a00ef7c97ecf8d3c
Autor:
Ralph V. Chamberlin
Publikováno v:
Entropy, Vol 26, Iss 3, p 190 (2024)
The 2nd law of thermodynamics yields an irreversible increase in entropy until thermal equilibrium is achieved. This irreversible increase is often assumed to require large and complex systems to emerge from the reversible microscopic laws of physics
Externí odkaz:
https://doaj.org/article/420a2cc696b64dfeb968ac04f8235c7a
Autor:
Gokhan Gundogdu, Travis Nguyen, Seyed Hossein Hosseini Sharifi, Stephanie Starek, Kyle Costa, Clara E. Jones, David Barham, Joel Gelman, Ralph V. Clayman, Joshua R. Mauney
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Background: The primary strategy for urinary diversion in radical cystectomy patients involves incorporation of autologous gastrointestinal conduits into the urinary tract which leads to deleterious consequences including chronic infections and metab
Externí odkaz:
https://doaj.org/article/73ba139af670441abf093fb918dc5d38
Autor:
Allison Lesher Williams, Chad B. Walton, Blake Pinell, Vedbar S. Khadka, Brandyn Dunn, Katie Lee, M. C. Therese Anagaran, Abigail Avelar, Ralph V. Shohet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Ischemic heart disease is a leading cause of heart failure and hypoxia inducible factor 1 (HIF1) is a key transcription factor in the response to hypoxic injury. Our lab has developed a mouse model in which a mutated, oxygen-stable form of H
Externí odkaz:
https://doaj.org/article/3358c57a1c804a2fa84edf3e2217d1eb
Nanothermodynamics provides the theoretical foundation for understanding stable distributions of statistically independent subsystems inside larger systems. In this review it is emphasized that adapting ideas from nanothermodynamics to simplistic mod
Externí odkaz:
http://arxiv.org/abs/2410.16335
Autor:
Ralph V. Chamberlin
Publikováno v:
Symmetry, Vol 14, Iss 10, p 2211 (2022)
We describe the behavior of an Ising model with orthogonal dynamics, where changes in energy and changes in alignment never occur during the same Monte Carlo (MC) step. This orthogonal Ising model (OIM) allows conservation of energy and conservation
Externí odkaz:
https://doaj.org/article/b9ec6b4590bd4a7e869ab597337bdfd8