Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ralph T. Kubo"'
Autor:
Lilia Koriazova, Steven W. Granger, Mohammed Rafii-El-Idrissi Benhnia, Shin-ichiro Kato, Megan McCausland, Ralph T. Kubo, John Laudenslager, Shane Crotty, Sandra Rickert, Juan Moyron
Publikováno v:
Journal of Virology. 83:1201-1215
Antibody neutralization is an important component of protective immunity against vaccinia virus (VACV). Two distinct virion forms, mature virion and enveloped virion (MV and EV, respectively), possess separate functions and nonoverlapping immunologic
Autor:
Laura Shapiro, Noelle J. Zhang, Ralph T. Kubo, Hitoshi Yoshida, Rongfang Wang, Toshifumi Mikayama, Lilia Koriazova, James Levin, Lydia Madura, Atsushi Matsumoto, Shinichiro Kato, Aihua Song, Dawna Dennis, Hideaki Yoshida, Sally R. Sarawar, Hilde Cheroutre
Publikováno v:
Antiviral Research. 80:168-177
Influenza is one of the most prevalent viral diseases in humans. For some high-risk human populations, including the infant, the elderly, and the immunocompromised, who may not benefit from active immunization, passive immunotherapy with antibodies r
Autor:
Julia Ponomarenko, Ward Fleri, Grace Doh, Ralph T. Kubo, Alessandro Sette, Ole Lund, Phil Bourne, Buus Soeren, Scott Stewart, Mitch Kronenberg, Steve Wilson, John Sidney, Stephen P. Schoenberger, Muthu Sathiamurthy, Scott Way, Pamela Surko, Bjoern Peters, David Nemazee, Huynh-Hoa Bui
Publikováno v:
Immunogenetics. 57:326-336
Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and f
Autor:
Ajesh Maewal, Alessandro Sette, Howard M. Grey, Carla Oseroff, Jeff Alexander, John Fikes, Carol Dahlberg, Robert W. Chesnut, Peggy Wentworth, Esteban Celis, Ralph T. Kubo
Publikováno v:
Vaccine. 16:823-833
Various peptide-based approaches to simultaneous induction of multiple cytotoxic T lymphocyte (CTL) responses were evaluated as part of ongoing efforts to develop immunotherapeutic vaccines for use in humans. To this end, HLA (human histocompatibilit
Autor:
Richard A. Franklin, Bruce Mazer, Reinhart Schwinzer, Ronald J. Harbeck, Anthony R. Hayward, Erwin W. Gelfand, Ralph T. Kubo
Publikováno v:
Clinical Immunology and Immunopathology. 84:129-138
Selective T cell deficiency is a rare immune deficiency characterized by the absence of CD8 + T lymphocytes and depressed/absent T cell function. This syndrome has been associated with mutations in the gene for ZAP-70, a tyrosine kinase that has prof
Autor:
Ettore Appella, Jeff Alexander, Alessandro Sette, Kazuyasu Sakaguchi, Howard M. Grey, Danila Valmori, Thomas Arrhenius, Ralph T. Kubo, Ajesh Maewal, Marie-France del Guercio, Stephen L. Hoffman, Trevor R. Jones
Publikováno v:
Vaccine. 15:441-448
Induction of humoral immune responses against protein antigen requires that two independent signals be delivered to B cells. It is currently assumed that simple monovalent synthetic peptides would not be effective immunogens for antibody responses be
Publikováno v:
Immunology Today. 17:261-266
Recent data suggest that the majority of HLA-A and -B alleles in human populations can be grouped into four major supertypes, as defined by their broad peptide-binding specificities. As discussed by John Sidney and colleagues, these data add to our u
Autor:
Tomoyuki Tahara, Shinichiro Kato, Megan McCausland, Ralph T. Kubo, Shane Crotty, Mohammed Rafii-El-Idrissi Benhnia, Steven W. Granger, John Laudenslager, Lindsay Crickard, Lilia Koriazova
Publikováno v:
Antiviral therapy. 15(4)
Background Treatment of rare severe side effects of vaccinia virus (VACV) immunization in humans is currently very challenging. VACV possesses two immunologically distinct virion forms in vivo — intracellular mature virion (MV, IMV) and extracellul
Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation
Publikováno v:
Proceedings of the National Academy of Sciences. 89:4947-4951
We have previously reported that mammalian tissue lymphocytes exhibit significant heterogeneity with respect to the subcellular distribution of spectrin and that this phenomenon may result from a dynamic behavior of spectrin in response to activation