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Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101551- (2022)
Summary: In this protocol, we use CRISPR/Cas9 to generate large deletions of the entire coding region of a gene of interest, generating a hemizygous cell line. Next, we systematically engineer precise in-frame deletions within the intact wild-type al
Externí odkaz:
https://doaj.org/article/cf04c21040b54664ad092286e10ec344
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101529- (2022)
Summary: Chromatin immunoprecipitation coupled with quantitative PCR (ChIP-qPCR) even with optimization may give low signal-to-background ratio and spatial resolution. Here, we adapted Cleavage Under Targets and Release Using Nuclease (CUT&RUN) (orig
Externí odkaz:
https://doaj.org/article/43fea6294a2d47e9bfb4d57950c783a8
Autor:
Rajula Elango, Arvind Panday, Francis P. Lach, Nicholas A. Willis, Kaitlin Nicholson, Erin E. Duffey, Agata Smogorzewska, Ralph Scully
Publikováno v:
Nat Struct Mol Biol
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise arrested forks, 'unhooking' the ICL and forming a double strand break (DSB) that is repaired by homologous recombination (HR). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21c2311ab2f1f53752438a58784c07a
https://doi.org/10.1038/s41594-022-00812-9
https://doi.org/10.1038/s41594-022-00812-9
Autor:
David M. Livingston, Jarrod A. Marto, Myles Brown, Ralph Scully, Michael J. Eck, Eunyoung Park, Shiliang A. Cao, Elgene Lim, Anyong Xie, Kimberly J. Toomire, Scott B. Ficarro, Sarah A. Petit, Yiduo Hu
This file includes supplementary figure legends, supplementary methods, and supplementary references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3278f377c44a95432d4f6c30356d1caa
https://doi.org/10.1158/2159-8290.22530476
https://doi.org/10.1158/2159-8290.22530476
Autor:
Gerburg M. Wulf, Lewis C. Cantley, John M. Asara, Ralph Scully, José Baselga, Pier Paolo Pandolfi, Caterina Nardella, Costas A. Lyssiotis, Katherine Spencer, Antonella Papa, Anbazhagan Rajendran, Judith Balmañà, Yasir H. Ibrahim, Elaine P. Lunsford, Hai Hu, Laura N. Burga, Ashish Juvekar
PDF file - 319K, Target inhibition after treatments with NVP-BKM120 in vivo. Tumor-bearing MMTV-CreBRCA1f/fp53+/- mice were biopsied before treatment, and tumor tissues harvested within 3 hours after the last treatment. Tissues were fixed and process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1398ed6f3fdcab01db488d89fe89b601
https://doi.org/10.1158/2159-8290.22529226.v1
https://doi.org/10.1158/2159-8290.22529226.v1
Autor:
Gerburg M. Wulf, Lewis C. Cantley, John M. Asara, Ralph Scully, José Baselga, Pier Paolo Pandolfi, Caterina Nardella, Costas A. Lyssiotis, Katherine Spencer, Antonella Papa, Anbazhagan Rajendran, Judith Balmañà, Yasir H. Ibrahim, Elaine P. Lunsford, Hai Hu, Laura N. Burga, Ashish Juvekar
PDF file - 526K, FDG-uptake and CT-PET scanning of mice before and after 2 weeks of treatment with NVP-BKM120. Tumor-bearing female MMTV-CreBRCA1f/fp53+/- mice were imaged with PET-CT scans before and after treatments with NVP-BKM120 at 50 mg/kg/day.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042b657504fec7d182fdbab88931d869
https://doi.org/10.1158/2159-8290.22529223.v1
https://doi.org/10.1158/2159-8290.22529223.v1
Autor:
Kwok-Kin Wong, Lewis C. Cantley, David E. Root, Nathanael S. Gray, Andrew L. Kung, William Y. Kim, David J. Kwiatkowski, John V. Heymach, Ignacio I. Wistuba, Don L. Gibbons, Lauren A. Byers, Alec Kimmelman, Ralph Scully, John M. Asara, Reuben J. Shaw, Brendan D. Manning, Jeffrey A. Engelman, Nabeel Bardeesy, Pasi A. Janne, Nirali M. Patel, D. Neil Hayes, Norman E. Sharpless, Sean T. Bailey, Jianming Zhang, Edward M. Driggers, Sung Choe, Xiaoxu Wang, Jeremy H. Tchaicha, Abigail B. Altabef, Zhao Chen, Yong Zhang, Peng Gao, Travis J. Cohoon, Chunxiao Xu, Thomas J.F. Nieland, Qingsong Liu, Julian Carretero, Glenn S. Cowley, Kevin Marks, Yan Liu
Top 200 genes by KS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aba35809716d259c0721faa29d78f09
https://doi.org/10.1158/2159-8290.22530554.v1
https://doi.org/10.1158/2159-8290.22530554.v1
Autor:
Gerburg M. Wulf, Lewis C. Cantley, John M. Asara, Ralph Scully, José Baselga, Pier Paolo Pandolfi, Caterina Nardella, Costas A. Lyssiotis, Katherine Spencer, Antonella Papa, Anbazhagan Rajendran, Judith Balmañà, Yasir H. Ibrahim, Elaine P. Lunsford, Hai Hu, Laura N. Burga, Ashish Juvekar
PDF file - 169K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7aed6bc2eb311b19cfcc4c53528de3a
https://doi.org/10.1158/2159-8290.22529208
https://doi.org/10.1158/2159-8290.22529208
Autor:
Gerburg M. Wulf, Lewis C. Cantley, John M. Asara, Ralph Scully, José Baselga, Pier Paolo Pandolfi, Caterina Nardella, Costas A. Lyssiotis, Katherine Spencer, Antonella Papa, Anbazhagan Rajendran, Judith Balmañà, Yasir H. Ibrahim, Elaine P. Lunsford, Hai Hu, Laura N. Burga, Ashish Juvekar
PDF file - 71K, In vitro responses of BRCA1-mutant breast cancer cell lines to treatments with NVP-BKM120 (1 muM), Olaparib (10 muM) or their combination. Cells were seeded in quadruplicate in 96-well plates and treated for 7 days as indicated. A. HC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141c3c8bd8873269a3d3412d1985e33e
https://doi.org/10.1158/2159-8290.22529217.v1
https://doi.org/10.1158/2159-8290.22529217.v1