Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ralph S Mazenko"'
Autor:
Christopher Lines, Kerry Budd, Ryan Vargo, Ralph S. Mazenko, Leo Verhagen Metman, Christopher Assaid, W. Joseph Herring, Aaron Ellenbogen
Publikováno v:
Clinical Neuropharmacology. 40:255-260
Objectives Blockade of N-methyl-D-aspartate receptors containing the NR2B subunit has been shown to be therapeutic in animal models of Parkinson disease (PD). However, findings with investigational NR2B receptor antagonists in PD patients have been m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893a012138bddd93703a46e5d76dac1c
https://doi.org/10.1097/wnf.0000000000000241
https://doi.org/10.1097/wnf.0000000000000241
Autor:
Arturo G. Porras, Nicole Michiels, Jutta Miller, Eric Woolf, Nancy G. B. Agrawal, Sean P. Curtis, Scott A. Waldman, Ralph S. Mazenko, A. Schultz, Howard E. Greenberg, Catherine Z. Matthews, Walter K. Kraft, Martin Wehling, Xun Chen, Alice B. Gottlieb, Keith Gottesdiener
Publikováno v:
The Journal of Clinical Pharmacology. 44:1125-1131
To investigate the influence of modifying in vivo cytochrome P450 3A (CYP3A) activity on the pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, and of etoricoxib administration on CYP3A activity, a 3-part, randomized, crossove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f502b80c10944c04f0b6a7b6f7877d07
https://doi.org/10.1177/0091270004268129
https://doi.org/10.1177/0091270004268129
Autor:
Peggy H. Wong, Catherine Z. Matthews, Josee Cote, Marshall Sack, Nancy G. B. Agrawal, Eric Woolf, Arturo G. Porras, Richard Robson, Leslie A. Geer, Suzanne K. Swan, W. F. Kline, Ralph S. Mazenko, Kevin J. Petty, Harry Alcorn, Keith Gottesdiener, Meehung Cho, Thomas Marbury, Jack W. Moncrief, Jules I. Schwartz
Publikováno v:
The Journal of Clinical Pharmacology. 44:48-58
The effect of renal insufficiency on the pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, was examined in 23 patients with varying degrees of renal impairment (12 moderate [creatinine clearance between 30 and 50 mL/min/1.73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7173647acce972895a25e7da4563bae1
https://doi.org/10.1177/0091270003260338
https://doi.org/10.1177/0091270003260338
Autor:
Sheila A Merschman, Barry J. Gertz, Kala-Jyoti Viswanathan-Aiyer, Nancy G. B. Agrawal, Kenneth C. Lasseter, Arturo G. Porras, Patrick Larson, Jules I. Schwartz, Ralph S Mazenko
Publikováno v:
Clinical Drug Investigation. 23:503-509
Objective: Rofecoxib suspension is a formulation developed to increase the convenience of rofecoxib therapy for patients who have difficulty swallowing tablets. This open-label, two-part study compared the single-dose pharmacokinetics of rofecoxib ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a466db050fafae19236cce54fb8af15a
https://doi.org/10.2165/00044011-200323080-00002
https://doi.org/10.2165/00044011-200323080-00002
Publikováno v:
Journal of Chromatography B. 779:249-257
Methods employing monolithic HPLC columns for the determination of the cyclooxygenase II inhibitors rofecoxib (I) and 3-isopropoxy-4-(4-methanesulfonylphenyl)-5,5′-dimethyl-5H-furan-2-one (DFP, III) in human plasma are described. Each analyte, toge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0435794543a0b254c63ed8c5331e43cc
https://doi.org/10.1016/s1570-0232(02)00380-x
https://doi.org/10.1016/s1570-0232(02)00380-x
Autor:
M.L Constanzer, George A. Doss, H. Haddix-Wiener, Ralph S. Mazenko, Catherine Z. Matthews, C.M Chavez-Eng, Bogdan K. Matuszewski, Eric Woolf
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 28:925-934
Methods for the quantitative determination of efavirenz in human plasma and the qualitative assessment of the stereochemical integrity of efavirenz in post-dose human plasma samples are described. After the addition of an internal standard, plasma sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b65e8e95814f4cba6557f571fc8d55
https://doi.org/10.1016/s0731-7085(01)00709-9
https://doi.org/10.1016/s0731-7085(01)00709-9
Autor:
Ravi Katwaru, Kenneth D. Anderson, Ralph S. Mazenko, Matt Zrada, Natasa Pajkovic, Lucinda H. Cohen, Paul Harradine, Haiping Wang, Bernard K. Choi, Kathy Cox, Vince Tong
Publikováno v:
Journal of pharmaceutical sciences. 103(10)
The experimental measurement of plasma protein binding is a useful in vitro Absorption Distribution Metabolism and Excretion(ADME) assay currently conducted in both screening and definitive early development candidate modes. The fraction unbound is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30105c0102c0e24389a101557dc2e14a
https://pubmed.ncbi.nlm.nih.gov/25116691
https://pubmed.ncbi.nlm.nih.gov/25116691
Publikováno v:
Journal of Microbiological Methods. 36:157-165
A novel assay utilizing immuno-labeling, filtration, and electrochemistry for the rapid detection of bacteria has been optimized for the detection of Escherichia coli O157:H7. Bacteria were specifically labeled with alkaline phosphatase conjugated po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402c6c6e9fdefde35162aedd9873045f
https://doi.org/10.1016/s0167-7012(99)00027-5
https://doi.org/10.1016/s0167-7012(99)00027-5
Autor:
Ralph S. Mazenko, Jeffrey D. Brewster
Publikováno v:
Journal of Immunological Methods. 211:1-8
A new approach for rapid assay of bacteria in liquid samples is described. Cells were labeled by incubation with an enzyme-antibody conjugate and captured by filtration of the sample/conjugate mixture through a 0.2 microm filter. The enzyme-labeled c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa8c7992d7911ae1a9ce6da3d6c1a3e
https://doi.org/10.1016/s0022-1759(97)00161-0
https://doi.org/10.1016/s0022-1759(97)00161-0
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 692:367-374
An affinity chromatography method was developed for the purification of hygromycin B from biological fluids. Lysozyme and alpha-lactalbumin were immobilized on an N-hydroxysuccinimide activated agarose support. Hygromycin B solubilized in water was b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef932defa5949cd85513379250fc39b
https://doi.org/10.1016/s0378-4347(97)00004-2
https://doi.org/10.1016/s0378-4347(97)00004-2