Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ralph Parchment"'
Autor:
Yves Pommier, John N. Weinstein, James Doroshow, Ralph Parchment, Robert Kinders, Thomas D. Pfister, Michael Ryan, Hongfang Liu, Jean-Louis Mergny, William C. Reinhold
Supplementary Figure 1 from Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03aa06f57472f0d05a389d150cc8e65
https://doi.org/10.1158/0008-5472.22387517.v1
https://doi.org/10.1158/0008-5472.22387517.v1
Autor:
Yves Pommier, John N. Weinstein, James Doroshow, Ralph Parchment, Robert Kinders, Thomas D. Pfister, Michael Ryan, Hongfang Liu, Jean-Louis Mergny, William C. Reinhold
Supplementary Figure 2B from Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4037102369f93fe1f6252461d5ebc1e5
https://doi.org/10.1158/0008-5472.22387514.v1
https://doi.org/10.1158/0008-5472.22387514.v1
Autor:
Yves Pommier, John N. Weinstein, James Doroshow, Ralph Parchment, Robert Kinders, Thomas D. Pfister, Michael Ryan, Hongfang Liu, Jean-Louis Mergny, William C. Reinhold
Supplementary Table 1 from Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218b5aab023335908715dd44d5f8e204
https://doi.org/10.1158/0008-5472.22387505.v1
https://doi.org/10.1158/0008-5472.22387505.v1
Autor:
Elisabeth A. Brown, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Zhengtao Chu, Jeevan Govindharajulu, Ralph Parchment, James Doroshow, Apurva Srivastava, Alana Welm
Publikováno v:
Cancer Research. 83:393-393
Background: Triple-Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer with few targeted therapies, limiting patients to harsh systemic treatments and resulting in the lowest 5-year survival rate of all breast cancer subtypes. Thi
Autor:
Daniel E. Jacobsen, Jenny K. Banh, Jessica Z. Kubicek-Sutherland, Kirk D. Rector, Ralph Parchment
Publikováno v:
Biophysical Journal. 122:274a
Autor:
Sarah J. Shin, Geraldine O'Sullivan Coyne, Howard Streicher, Naoko Takebe, Ashley Bruns, Elad Sharon, Richard Piekarz, Lamin Juwara, Larry Rubinstein, Ralph Parchment, Kristin Fino, King L. Fung, Katherine Ferry-Galow, Arjun Mittra, Abdul Rafeh Naqash, Kevin Conlon, James H. Doroshow, Alice P. Chen
Publikováno v:
Cancer Research. 82:CT147-CT147
Introduction: Recombinant human interleukin 15 (rhIL-15) has been shown to stimulate the activation and expansion in the number of effector T lymphocytes and natural killer cells in patients. The addition of the immune checkpoint inhibitors (ICI) CTL
Autor:
Curtis Hose, Erik Harris, John Connelly, Petreena S. Campbell, Mariaestela Ortiz, Eric Jones, Dianne Newton, Yvonne A. Evrard, Melinda Hollingshead, Ralph Parchment, Beverly A. Teicher, Nathan P. Coussens, James H. Doroshow, Annamaria Rapisarda
Publikováno v:
Cancer Research. 82:3091-3091
Patient-derived organoids (PDOrgs) are heterogeneous three-dimensional cellular clusters that have been shown to recapitulate the tumor histology and genetic alterations of their originating tissue. Numerous studies suggest the in vitro drug response
Autor:
Mohamad Adham Salkeni, Geraldine O’Sullivan Coyne, Naoko Takebe, Elad Sharon, Howard Streicher, Jessica Mukherjee, Ashley Bruns, Arjun Mitra, Abdul R. Naqash, Larry Rubinstein, Kristin K. Fino, King L. Fung, Katherine Ferry-Galow, Ralph Parchment, Helen Chen, James Doroshow, Alice Chen
Publikováno v:
Cancer Research. 82:CT115-CT115
Background: It is hypothesized that chemotherapy alters the tumor microenvironment (TME) by increasing T cell infiltration and enhancing antigen presentation to T cells, and thereby may enhance immune-mediated cytotoxicity and tumor response to immun
Autor:
Mohamad A. Salkeni, Geraldine O’Sullivan Coyne, Jennifer Zlott, Naoko Takebe, Ning Ma, Larry Rubinstein, Richard Piekarz, Jared Foster, Brandon Miller, Ralph Parchment, Abdul R. Naqash, Andrea Voth, James Doroshow, Alice Chen
Publikováno v:
Molecular Cancer Therapeutics. 20:P049-P049
Background: TRC102 binds to abasic sites in DNA, inhibiting the base excision repair (BER) pathway, which is implicated in resistance to alkylating agents. Preclinical xenograft studies in mice demonstrated a synergistic anti-tumor effect when TRC102
Autor:
Geraldine OSullivan Coyne, Sabrina S. Khan, Kevin Conlon, Howard Streicher, Ashley Bruns, Richard Piekarz, Naoko Takebe, Lamin Juwara, Ralph Parchment, Tony Navas, Kirstin Fino, King L. Fung, Elad Sharon, James H. Doroshow, Thomas A. Waldmann, Alice P. Chen
Publikováno v:
Cancer Research. 79:LB-015
Introduction: Treatment with rhIL-15 has been reported to significantly increase levels of circulating CD8+ T cells, NK cells, and inflammatory cytokines. In vivo administration of rhIL-15 with immune checkpoints inhibitors of CTLA-4 and PD-L1 result