Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ralph Pantophlet"'
Autor:
Zabrina L. Brumme, Francis Mwimanzi, Hope R. Lapointe, Peter K. Cheung, Yurou Sang, Maggie C. Duncan, Fatima Yaseen, Olga Agafitei, Siobhan Ennis, Kurtis Ng, Simran Basra, Li Yi Lim, Rebecca Kalikawe, Sarah Speckmaier, Nadia Moran-Garcia, Landon Young, Hesham Ali, Bruce Ganase, Gisele Umviligihozo, F. Harrison Omondi, Kieran Atkinson, Hanwei Sudderuddin, Junine Toy, Paul Sereda, Laura Burns, Cecilia T. Costiniuk, Curtis Cooper, Aslam H. Anis, Victor Leung, Daniel Holmes, Mari L. DeMarco, Janet Simons, Malcolm Hedgcock, Marc G. Romney, Rolando Barrios, Silvia Guillemi, Chanson J. Brumme, Ralph Pantophlet, Julio S. G. Montaner, Masahiro Niikura, Marianne Harris, Mark Hull, Mark A. Brockman
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike protein receptor-binding domain (RBD), ACE2 displacement and viral neu
Externí odkaz:
https://doaj.org/article/aa9bbdca3ccd41fdb2e9b2db8e984af2
Autor:
Jean-François Bruxelle, Tess Kirilenko, Nino Trattnig, Yiqiu Yang, Matteo Cattin, Paul Kosma, Ralph Pantophlet
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM197-conjugate of a p
Externí odkaz:
https://doaj.org/article/6e82ed37f9564815b8027762ff199af6
Autor:
Ralph Pantophlet, Nino Trattnig, Sasha Murrell, Naiomi Lu, Dennis Chau, Caitlin Rempel, Ian A. Wilson, Paul Kosma
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody
Externí odkaz:
https://doaj.org/article/6f723175653248f8b81328e5c6e0e922
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 228 (2021)
Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after infection, which poses a major challenge for drug treatment and curative strategies. Many efforts are therefore focused on blocking infection. To this end, bo
Externí odkaz:
https://doaj.org/article/063bda00769d4030aa2b57352a8e213f
Autor:
Lubina Khan, Muzamil Ashraf Makhdoomi, Sanjeev Kumar, Ambili Nair, Raiees Andrabi, Brenda E Clark, Kate Auyeung, Jayanta Bhattacharya, Madhu Vajpayee, Naveet Wig, Ralph Pantophlet, Kalpana Luthra
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125575 (2015)
Dissecting antibody specificities in the plasma of HIV-1 infected individuals that develop broadly neutralizing antibodies (bNAbs) is likely to provide useful information for refining target epitopes for vaccine design. Several studies have reported
Externí odkaz:
https://doaj.org/article/5920a5117ee44dd8b4015bc1a45a87bf
Autor:
Olivia Garland, Anh-Tien Ton, Shoeib Moradi, Jason R. Smith, Suzana Kovacic, Kurtis Ng, Mohit Pandey, Fuqiang Ban, Jaeyong Lee, Marija Vuckovic, Liam J. Worrall, Robert N. Young, Ralph Pantophlet, Natalie C. J. Strynadka, Artem Cherkasov
Publikováno v:
Journal of Chemical Information and Modeling. 63:2158-2169
Autor:
Hope R Lapointe, Francis Mwimanzi, Peter K Cheung, Yurou Sang, Fatima Yaseen, Gisele Umviligihozo, Rebecca Kalikawe, Sarah Speckmaier, Nadia Moran-Garcia, Sneha Datwani, Maggie C Duncan, Olga Agafitei, Siobhan Ennis, Landon Young, Hesham Ali, Bruce Ganase, F Harrison Omondi, Winnie Dong, Junine Toy, Paul Sereda, Laura Burns, Cecilia T Costiniuk, Curtis Cooper, Aslam H Anis, Victor Leung, Daniel T Holmes, Mari L DeMarco, Janet Simons, Malcolm Hedgcock, Natalie Prystajecky, Christopher F Lowe, Ralph Pantophlet, Marc G Romney, Rolando Barrios, Silvia Guillemi, Chanson J Brumme, Julio S G Montaner, Mark Hull, Marianne Harris, Masahiro Niikura, Mark A Brockman, Zabrina L Brumme
Publikováno v:
The Journal of Infectious Diseases. 227:838-849
Background Longer-term humoral responses to 2-dose coronavirus disease 2019 (COVID-19) vaccines remain incompletely characterized in people living with human immunodeficiency virus (HIV) (PLWH), as do initial responses to a third dose. Methods We mea
Autor:
Tess Kirilenko, Jean-François Bruxelle, Nino Trattnig, Paul Kosma, Yiqiu Yang, Ralph Pantophlet, Matteo Cattin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM197-conjugate of a previously
Autor:
Hope R. Lapointe, Francis Mwimanzi, Peter K. Cheung, Yurou Sang, Fatima Yaseen, Gisele Umviligihozo, Rebecca Kalikawe, Sarah Speckmaier, Nadia Moran-Garcia, Sneha Datwani, Maggie C. Duncan, Olga Agafitei, Siobhan Ennis, Landon Young, Hesham Ali, Bruce Ganase, F. Harrison Omondi, Winnie Dong, Junine Toy, Paul Sereda, Laura Burns, Cecilia T. Costiniuk, Curtis Cooper, Aslam H. Anis, Victor Leung, Daniel Holmes, Mari L. DeMarco, Janet Simons, Malcolm Hedgcock, Natalie Prystajecky, Christopher F. Lowe, Ralph Pantophlet, Marc G. Romney, Rolando Barrios, Silvia Guillemi, Chanson J. Brumme, Julio S.G. Montaner, Mark Hull, Marianne Harris, Masahiro Niikura, Mark A. Brockman, Zabrina L. Brumme
Publikováno v:
medRxiv
BackgroundLonger-term humoral responses to two-dose COVID-19 vaccines remain incompletely characterized in people living with HIV (PLWH), as do initial responses to a third dose.MethodsWe measured antibodies against the SARS-CoV-2 spike protein recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827244a3c69a3e039fdf63ccc61dc884
https://doi.org/10.1101/2022.03.22.22272793
https://doi.org/10.1101/2022.03.22.22272793
Autor:
Francis Mwimanzi, Hope R. Lapointe, Peter K. Cheung, Yurou Sang, Fatima Yaseen, Gisele Umviligihozo, Rebecca Kalikawe, Sneha Datwani, F. Harrison Omondi, Laura Burns, Landon Young, Victor Leung, Olga Agafitei, Siobhan Ennis, Winnie Dong, Simran Basra, Li Yi Lim, Kurtis Ng, Ralph Pantophlet, Chanson J. Brumme, Julio S.G. Montaner, Natalie Prystajecky, Christopher F. Lowe, Mari L. DeMarco, Daniel T. Holmes, Janet Simons, Masahiro Niikura, Marc G. Romney, Zabrina L. Brumme, Mark A. Brockman
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Background. Two-dose mRNA vaccines reduce COVID-19 related hospitalization and mortality, but immune protection declines over time. As such, third vaccine doses are now recommended, particularly for older adults. We examined immune response durabilit