Výsledky vyhledávání - "Ralph P. Walker"

The role of intestinal microflora in the metabolic activation of 6-nitrochrysene to DNA-binding derivatives in mice

Autor: Wirt Franklin, Kenneth L. Dooley, Warren L. Campbell, Carl E. Cerniglia, K. Barry Delclos, Ralph P. Walker

Publikováno v: Toxicology. 60:137-150

6-Nitrochrysene has previously been shown to be a potent lung and liver carcinogen following i.p. administration to newborn mice and to be metabolically activated to DNA-binding derivatives by nitro-reduction or a combination of nitro-reduction and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a54259bb8c72fc970f309445e0fd6f6
https://doi.org/10.1016/0300-483x(90)90168-g

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Metabolic Activation of 6-Nitrochrysene and 6-Aminochrysene in Vitro and in Vivo

Autor: Ralph P. Walker, Jean-Paul Sculier, Glenn Talaska, Christiane Brassinne, K. Barry Delclos

Publikováno v: Nitroarenes ISBN: 9781461366942

The well-documented mutagenicities and tumorigenicities of many nitro polycyclic aromatic hydrocarbons (nitro PAHs) in experimental models have raised the issue of the potential hazards of exposure to these compounds to humans. While several nitro PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6db9bbb146473b4ba330b2fb297638b
https://doi.org/10.1007/978-1-4615-3800-4_27

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Identification of C8-modified deoxyinosine and N2-and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts in isolated rat hepatocytes treated with 6-nitrochrysene and 6-aminochrysene

Autor: K. Barry Delclos, Ralph P. Walker, Fred F. Kadlubar, Jackson O. Lay, Dwight W. Miller, Daniel A. Casciano, Peter P. Fu

Publikováno v: Carcinogenesis. 8:1703-1709

Since 6-nitrochrysene and 6-aminochrysene have shown activity in carcinogenicity bioassays, we have begun an investigation of their metabolic activation pathways and the nature of the carcinogen-DNA adducts that may be formed. N-Hydroxy-6-aminochryse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8584d57a8cb2ab5ac2c1198006a3e9ef
https://doi.org/10.1093/carcin/8.11.1703

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Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium

Autor: Stephen S. Hecht, Karam El-Bayoumy, Gong Huey Shiue, Robert H. Heflich, K. Barry Delcios, Ralph P. Walker

Publikováno v: Mutagenesis. 4(3)

The mutagenic activities of 6-nitrochrysene (6-NC) and its previously identified metabolites were evaluated in Salmonella typhimurium TA100 and TA98 in the presence and absence of metabolic activation by 9000 g supernatant from the livers of rats tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e8f38a2f175b721d5aaec36532a70c
https://pubmed.ncbi.nlm.nih.gov/2659942

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Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite

Autor: Ralph P. Walker, Karan Ei Bayoumy, Stephen S. Hecht, Fred F. Kadlubar, K. Barry Delclos

Publikováno v: Carcinogenesis. 9(10)

6-Nitrochrysene (NC) is a potent lung and liver carcinogen when administered in multiple doses to preweanling mice. We have investigated both the in vitro metabolism of [3H]NC by 9000 g supernatants (S9) prepared from the livers of preweanling mice a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1393b85b518217786c9cb5411c8c406a
https://pubmed.ncbi.nlm.nih.gov/3168165

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