Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ralph N. Watts"'
Publikováno v:
Clinical Cancer Research. 15:6490-6494
Purpose: Lactate dehydrogenase (LDH) levels in blood of patients with melanoma have proven to be an accurate predictor of prognosis and response to some treatments. Exclusion of patients with high LDH levels from many trials of new treatments has cre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915de84a4f2dee883da0f44db7d7bccc
https://doi.org/10.1158/1078-0432.ccr-09-0251
https://doi.org/10.1158/1078-0432.ccr-09-0251
Autor:
Rick F. Thorne, Xudong Zhang, Kelly A. Kiejda, Lihua Chen, Ralph N. Watts, Peter Hersey, Chen Chen Jiang
Publikováno v:
Cancer Research. 68:834-842
We have shown previously that most melanoma cell lines are insensitive to endoplasmic reticulum (ER) stress–induced apoptosis, but resistance can be reversed through activation of caspase-4 by inhibition of the MEK/ERK pathway. We report in this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d61f6e484af5bd455fd56a7c3b36abb
https://doi.org/10.1158/0008-5472.can-07-5056
https://doi.org/10.1158/0008-5472.can-07-5056
Activation of Jun N-terminal kinase is a mediator of vincristine-induced apoptosis of melanoma cells
Autor:
Lihua Chen, Ralph N. Watts, Bi-ke Zhu, Ping Wang, Xudong Zhang, Kelly A. Avery-Kiejda, Peter Hersey, Chen Chen Jiang
Publikováno v:
Anti-Cancer Drugs. 19:189-200
The molecular changes involved in the induction of apoptosis by vincristine in melanoma have not yet been well defined. Two human melanoma cell lines showing moderate (Mel-RM) and high (IgR3) sensitivity to vincristine were selected from a panel of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e001a5c4c868c6ae1dd0866abf9b97c4
https://doi.org/10.1097/cad.0b013e3282f3138a
https://doi.org/10.1097/cad.0b013e3282f3138a
Publikováno v:
Anti-Cancer Drugs. 17:1151-1161
Phenoxodiol is a chemically modified analogue of the plant hormone isoflavone with antitumour activities. In the present study, we have examined its ability to induce apoptosis in human melanoma cells and the mechanisms involved. Apoptosis was observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72ae3851036686632ee0434672d3e0
https://doi.org/10.1097/01.cad.0000231484.17063.9a
https://doi.org/10.1097/01.cad.0000231484.17063.9a
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7670-7675
Nitrogen monoxide (NO) plays a role in the cytotoxic mechanisms of activated macrophages against tumor cells by inducing iron (Fe) release. We have shown that NO-mediated Fe efflux from cells required glutathione (GSH), and we have hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed658a9ef08d47da6780d5fc94e4a49
https://doi.org/10.1073/pnas.0602515103
https://doi.org/10.1073/pnas.0602515103
Publikováno v:
Clinical Cancer Research. 10:7365-7374
Purpose: The development of novel and potent iron chelators as clinically useful antitumor agents is an area of active interest. Antiproliferative activity of chelators often relates to iron deprivation or stimulation of iron-dependent free radical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d5e6e6778007185dd9fb26eff1465d
https://doi.org/10.1158/1078-0432.ccr-04-0865
https://doi.org/10.1158/1078-0432.ccr-04-0865
Publikováno v:
British Journal of Pharmacology. 138:819-830
In an attempt to develop chelators as potent anti-tumour agents, we synthesized two series of novel ligands based on the very active 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) group. Since lipophilicity and membrane permeability play a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478369a3f410afd8d8611f5a0974cd1a
https://doi.org/10.1038/sj.bjp.0705089
https://doi.org/10.1038/sj.bjp.0705089
Autor:
Des R. Richardson, Ralph N. Watts
Publikováno v:
European Journal of Biochemistry. 269:3383-3392
Nitrogen monoxide (NO) is a cytotoxic effector molecule produced by macrophages that results in Fe mobilization from tumour target cells which inhibits DNA synthesis and mitochondrial respiration. It is well known that NO has a high affinity for Fe,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162f730cc303f1230db7fe0ed0b4fd0f
https://doi.org/10.1046/j.1432-1033.2002.02987.x
https://doi.org/10.1046/j.1432-1033.2002.02987.x
Autor:
Des R. Richardson, Ralph N. Watts
Publikováno v:
Journal of Biological Chemistry. 276:4724-4732
Nitrogen monoxide (NO) affects cellular iron metabolism due to its high affinity for this metal ion. Indeed, NO has been shown to increase the mRNA binding activity of the iron-regulatory protein 1, which is a major regulator of iron homeostasis. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f062c48904c1249d5a95a71589bc1b17
https://doi.org/10.1074/jbc.m006318200
https://doi.org/10.1074/jbc.m006318200
Autor:
Des R. Richardson, Ralph N. Watts
Publikováno v:
Journal of Laboratory and Clinical Medicine. 136:149-156
Nitrogen monoxide (NO) exerts many of its functions by binding to iron (Fe) in the active sites of a number of key proteins. Previously we have shown that NO produced by NO-generating agents decreased cellular Fe uptake from transferrin (Tf). However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ea9ce51e7ea3d08b1da79d6ae36958
https://doi.org/10.1067/mlc.2000.108152
https://doi.org/10.1067/mlc.2000.108152