Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ralph Minter"'
Autor:
Sophia K. Berry, Steven Rust, Lorraine Irving, Josefin Bartholdson Scott, Lucy A. Weinert, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J. Grant
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT We used phage display, antibody engineering, and high-throughput assays to identify antibody-accessible targets of Klebsiella pneumoniae. We report the discovery of monoclonal antibodies (mAbs) binding to type 3 fimbrial proteins, including
Externí odkaz:
https://doaj.org/article/95aa0fb605154b428c64e9bc9b28abc5
Autor:
Sophia K. Berry, Steven Rust, Carolina Caceres, Lorraine Irving, Josefin Bartholdson Scott, David E. Tabor, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter, Andrew J. Grant
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The increasing global occurrence of recalcitrant multi-drug resistant Klebsiella pneumoniae infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display
Externí odkaz:
https://doaj.org/article/f5b2bd62c6a24a919b1bf35d4d9e5d1d
Autor:
Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, tha
Externí odkaz:
https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
Autor:
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRA
Externí odkaz:
https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
Autor:
Jacob D. Galson, Sebastian Schaetzle, Rachael J. M. Bashford-Rogers, Matthew I. J. Raybould, Aleksandr Kovaltsuk, Gavin J. Kilpatrick, Ralph Minter, Donna K. Finch, Jorge Dias, Louisa K. James, Gavin Thomas, Wing-Yiu Jason Lee, Jason Betley, Olivia Cavlan, Alex Leech, Charlotte M. Deane, Joan Seoane, Carlos Caldas, Daniel J. Pennington, Paul Pfeffer, Jane Osbourn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B cell population is also
Externí odkaz:
https://doaj.org/article/77318244b0ea49a7afe210f8b341f044
Autor:
Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang, Nicolas Bery, Rose Marwood, Jon Tart, Ross Overman, Pawel Stocki, Bina Mistry, Christopher Phillips, Terence Rabbitts, Ronald Jackson, Ralph Minter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilit
Externí odkaz:
https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e
Autor:
Paula MacGregor, Andrea L Gonzalez-Munoz, Fatoumatta Jobe, Martin C Taylor, Steven Rust, Alan M Sandercock, Olivia J S Macleod, Katrien Van Bocxlaer, Amanda F Francisco, Francois D'Hooge, Arnaud Tiberghien, Conor S Barry, Philip Howard, Matthew K Higgins, Tristan J Vaughan, Ralph Minter, Mark Carrington
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007373 (2019)
Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been
Externí odkaz:
https://doaj.org/article/78f44b97ff384aeaad7bf4d99e7e1faf
Autor:
Matthew Kraman, Carlo Zimarino, Danielle Minns, Jorge Dias, Chelsea Povall, Helen Graves, Bradley Holub, Ralph Minter, Jacob Galson, Jane Osbourn, Donna Finch
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Daniel Cannon, Bojana Popovic, D. Gareth Rees, Ralph Minter, Andrew Buchanan, Kalliopi Skamaki, Stéphane Emond, John Andrews, Florian Hollfelder, Matthieu Chodorge
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
We report a systematic combinatorial exploration of affinity enhancement of antibodies by insertions and deletions (InDels). Transposon-based introduction of InDels via the method TRIAD (transposition-based random insertion and deletion mutagenesis)
Autor:
Lori Peacock, Olivia J. S. Macleod, Jean-Mathieu Bart, Sophie Ravel, Svenja Hester, Martin C. Taylor, Camilla Trevor, Ralph Minter, Jack D. Sunter, Tristan J. Vaughan, Wendy Gibson, Paula MacGregor, Steven Rust, Matthew K. Higgins, Shabaz Mohammed, Mark Carrington, Nicholas J. Savill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Macleod, O J S, Bart, J M, MacGregor, P, Peacock, L, Savill, N J, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, no. 1, 1326 . https://doi.org/10.1038/s41467-020-15125-y
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, art. 1326 [12 p.]. ⟨10.1038/s41467-020-15125-y⟩
Macleod, O J S, Bart, J-M, Macgregor, P, Peacock, L, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, 1326 (2020) . https://doi.org/10.1038/s41467-020-15125-y
Macleod, O J S, Bart, J M, MacGregor, P, Peacock, L, Savill, N J, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, no. 1, 1326 . https://doi.org/10.1038/s41467-020-15125-y
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11, art. 1326 [12 p.]. ⟨10.1038/s41467-020-15125-y⟩
Macleod, O J S, Bart, J-M, Macgregor, P, Peacock, L, Hester, S, Ravel, S, Sunter, J D, Trevor, C, Rust, S, Vaughan, T J, Minter, R, Mohammed, S, Gibson, W, Taylor, M C, Higgins, M K & Carrington, M 2020, ' A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies ', Nature Communications, vol. 11, 1326 (2020) . https://doi.org/10.1038/s41467-020-15125-y
Persistent pathogens have evolved to avoid elimination by the mammalian immune system including mechanisms to evade complement. Infections with African trypanosomes can persist for years and cause human and animal disease throughout sub-Saharan Afric