Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ralph M. Bernstein"'
Publikováno v:
International Immunology. 20:1381-1393
B lymphocytes switch from secreting IgM to secreting IgG, IgA or IgE through a DNA recombination, class switch recombination (CSR), whose mechanism is incompletely understood. CSR is thought to be triggered by activation-induced deaminase (AID), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c622bb4cfd2dc88cbe7b875ad1bc00de
https://doi.org/10.1093/intimm/dxn097
https://doi.org/10.1093/intimm/dxn097
Publikováno v:
The Journal of Immunology. 179:5264-5273
The 3-megabase Igkappa locus undergoes differentially controlled nuclear positioning events and chromatin structural changes during the course of B cell development. The temporal association of chromatin structural changes, transcription, and recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160e4a3b4c67c704c72efed1ba3d3c02
https://doi.org/10.4049/jimmunol.179.8.5264
https://doi.org/10.4049/jimmunol.179.8.5264
Publikováno v:
The Journal of Immunology. 173:3223-3229
Class switch recombination (CSR) at the DNA level underlies ability of B lymphocytes to switch from expressing IgM to expressing IgG, IgA, or IgE. The mechanism of CSR is largely unknown, but it is clear that CSR is stimulated by T cell signals and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac97e1c353d6212ebf109129a73088c9
https://doi.org/10.4049/jimmunol.173.5.3223
https://doi.org/10.4049/jimmunol.173.5.3223
Autor:
Qiang Pan, Yanzhong Hu, Lennart Hammarström, Ralph M. Bernstein, Evangelia Pardali, Frederick C. Mills, Paschalis Sideras, Edward E. Max
Publikováno v:
The Journal of Immunology. 164:6380-6386
The human IgH 3′ enhancers, located downstream of each of the two Cα genes, modulate germline (GL) transcription of the IgH genes by influencing the activity of promoter-enhancer complexes upstream of the switch and intervening (I) regions. The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e197f05fce42ce1547e5a710e072b755
https://doi.org/10.4049/jimmunol.164.12.6380
https://doi.org/10.4049/jimmunol.164.12.6380
Publikováno v:
Developmental & Comparative Immunology. 23:107-111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee932ec2b1305bc3b503482753488c44
https://doi.org/10.1016/s0145-305x(99)00002-6
https://doi.org/10.1016/s0145-305x(99)00002-6
Publikováno v:
Immunology Today. 18:543-549
Cartilaginous fish are the most ancient extant jawed vertebrates possessing bona fide immunoglobulin (Ig) and T-cell receptor molecules. The study of these animals is critical for understanding the origins of the vertebrate immune system. Here, Samue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c8f7ea1e941eef62e880793e0ac620
https://doi.org/10.1016/s0167-5699(97)01153-5
https://doi.org/10.1016/s0167-5699(97)01153-5
Publikováno v:
Proceedings of the National Academy of Sciences. 93:9454-9459
The rearrangement of antibody and T-cell receptor gene segments is indispensable to the vertebrate immune response. All extant jawed vertebrates can rearrange these gene segments. This ability is conferred by the recombination activating genes I and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a735885633da2ec9dfda4485a9300db
https://doi.org/10.1073/pnas.93.18.9454
https://doi.org/10.1073/pnas.93.18.9454
Publikováno v:
Immunology and Cell Biology. 74:357-364
We determined the sequence of 18 DNA clones encoding VH regions of sandbar shark and bull shark. All of these sequences exhibit key structural coding features characteristic of known VH genes of higher vertebrates. These VH sequences disclosed consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e702116d6b156230fcc8f5ad3cc88a
https://doi.org/10.1038/icb.1996.63
https://doi.org/10.1038/icb.1996.63
Autor:
Douglas J. Jolly, Ralph M. Bernstein, Samuel F. Schluter, Shanxiang Shen, Ramarao Gangavalli, Alison Stopeck, Emmanuel T. Akporiaye, Ena Wang, Jack R. Barber, Monica C. Panelli, Evan M. Hersh
Publikováno v:
Cancer Immunology, Immunotherapy. 42:99-107
Interferon gamma (IFNgamma) is an important cytokine with immunomodulatory properties that include activation of immune cells and induction of class I and class II major histocompatibility complex antigens. In this study a retroviral vector was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47ce849205e6277c928bd184ccdc7ee
https://doi.org/10.1007/s002620050258
https://doi.org/10.1007/s002620050258
Publikováno v:
Glycobiology. 6:657-663
The immune response of jawed vertebrates is an inducible, highly specific defense mechanism that is characterized by an enormous diversity in recognition capacity. This allows responses to potential pathogens that have never been previously encounter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf4b974bef9ea7ebc5000ff6f70a81
https://doi.org/10.1093/glycob/6.7.657
https://doi.org/10.1093/glycob/6.7.657