Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ralph L. White"'
Publikováno v:
Journal of Pharmaceutical Sciences. 69:327-331
A series of quaternary ammonium salts of dantrolene and clodanolene was prepared and evaluated for skeletal muscle relaxant activity. The quaternary ammonium salts exhibit greater aqueous solubility and, therefore, facilitate intravenous administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55e628474529dba63c8a9d16a99633b
https://doi.org/10.1002/jps.2600690319
https://doi.org/10.1002/jps.2600690319
Autor:
Schwe Fang Pong, Ralph L. White, Chau Ting Huang, Alan F. Moore, Robert R. Brooks, James R. Skuster
Publikováno v:
Drug Development Research. 7:141-151
EU-5476 is a new, orally active angiotensin I-converting enzyme (ACE) inhibitor. In vitro, EU-5476 produced a concentration-dependent inhibition of ACE purified from rabbit lung (IC50 = 0.084 μ). Inhibition showed complex kinetics and was reversible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f56aa193b81d8bc03a6610481414dbec
https://doi.org/10.1002/ddr.430070205
https://doi.org/10.1002/ddr.430070205
Autor:
Ralph L. White, Thomas J. Schwan
Publikováno v:
Chemischer Informationsdienst. 7
The synthesis and structural elucidation of 5‐hydroxy‐1‐[[5‐( p ‐nitrophenyl)furfurylidene]amino]hydantoin, a compound proposed as a metabolite of dantrolene sodium, are reported. In addition, a chromatographic comparison of the biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f54d4b4b5e37db6cbc344ce661f0da
https://doi.org/10.1002/chin.197619247
https://doi.org/10.1002/chin.197619247
Publikováno v:
Journal of medicinal chemistry. 21(1)
A series of 5-hydroxy substitution products of 2,4-imidazolidinediones, including the 5-hydroxy metabolite of the skeletal muscle contraction antagonist, dantrolene sodium, has been synthesized and evaluated for skeletal muscle relaxant activity. Mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133527d75829550138fb2ca3750bc07a
https://pubmed.ncbi.nlm.nih.gov/619142
https://pubmed.ncbi.nlm.nih.gov/619142
Publikováno v:
Journal of medicinal chemistry. 30(2)
A series of 1-[[[5-(substituted phenyl)-2-oxazolyl]methylene]amino]- 2,4-imidazolidinediones (6a-t) was synthesized, and the compounds were evaluated for direct skeletal muscle inhibition in the pithed rat gastrocnemius muscle preparation. The correc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950e491b0a016c8c5b76e6f6f51d1551
https://pubmed.ncbi.nlm.nih.gov/3806610
https://pubmed.ncbi.nlm.nih.gov/3806610
Publikováno v:
Chemischer Informationsdienst. 8
The synthesis of 5-hydroxy-1-[[(5-nitro-2-furanyl)methylenelamino]-2,4-imidazolidinedione is described, and its antibacterial activity is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37da486ea5f4e6a65dac6fe23b4d9b53
https://doi.org/10.1002/chin.197745229
https://doi.org/10.1002/chin.197745229
Publikováno v:
Journal of pharmaceutical sciences. 70(9)
A series of 3-(aminoacyl)-1-[[[5-(substituted phenyl)-2-furanyl]methylene]amino]-2, 4-imidazolidinediones was synthesized and evaluated for skeletal muscle relaxant activity. All compounds were active by the intravenous route, and nine of 11 were act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fbda010f5c4198943fab5c897f1ab2
https://pubmed.ncbi.nlm.nih.gov/6101163
https://pubmed.ncbi.nlm.nih.gov/6101163
Publikováno v:
Chemischer Informationsdienst. 9
A series of 5-hydroxy substitution products of 2,4-imidazolidinediones, including the 5-hydroxy metabolite of the skeletal muscle contraction antagonist, dantrolene sodium, has been synthesized and evaluated for skeletal muscle relaxant activity. Mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fce2a9ce1b9cb9cd0d359606881bd86
https://doi.org/10.1002/chin.197821208
https://doi.org/10.1002/chin.197821208
Publikováno v:
Journal of Pharmaceutical Sciences. 66:277-278
The synthesis of 5-hydroxy-1-[[(5-nitro-2-furanyl)methylenelamino]-2,4-imidazolidinedione is described, and its antibacterial activity is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbe206ede5c3218ca7fa4badd347784
https://doi.org/10.1002/jps.2600660238
https://doi.org/10.1002/jps.2600660238
Publikováno v:
Journal of Heterocyclic Chemistry. 17:817-818
The conversion of 2-chloromethyl-5-methoxy-4H-pyran-4-one to 2-amino-5-hydroxy-6-methoxybenzothiazole hydrochloride under mild reaction conditions has been observed. The synthesis of the identical benzothiazole by an alternate unequivocal method is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad78f73a77e18ef03eb9453144d1b0bb
https://doi.org/10.1002/jhet.5570170442
https://doi.org/10.1002/jhet.5570170442