Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ralph Krafczyk"'
Autor:
Ralph Krafczyk, Fei Qi, Alina Sieber, Judith Mehler, Kirsten Jung, Dmitrij Frishman, Jürgen Lassak
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Ralph Krafczyk et al. demonstrate that both proline codon usage and prolyl-tRNA abundance affect mRNA translation rates of polyproline-motifs in bacteria. These results provide additional insight into sequence-specific translation regulation.
Externí odkaz:
https://doaj.org/article/b4af811cdec04b86b9f2d2ab3de7d104
Autor:
Wolfram Volkwein, Ralph Krafczyk, Pravin Kumar Ankush Jagtap, Marina Parr, Elena Mankina, Jakub Macošek, Zhenghuan Guo, Maximilian Josef Ludwig Johannes Fürst, Miriam Pfab, Dmitrij Frishman, Janosch Hennig, Kirsten Jung, Jürgen Lassak
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Tripeptides with two consecutive prolines are the shortest and most frequent sequences causing ribosome stalling. The bacterial translation elongation factor P (EF-P) relieves this arrest, allowing protein biosynthesis to continue. A seven amino acid
Externí odkaz:
https://doaj.org/article/fe7ad7c7b8a647ccb645ebe6c6169dd8
Autor:
Ralph Krafczyk, Jakub Macošek, Pravin Kumar Ankush Jagtap, Daniel Gast, Swetlana Wunder, Prithiba Mitra, Amit Kumar Jha, Jürgen Rohr, Anja Hoffmann-Röder, Kirsten Jung, Janosch Hennig, Jürgen Lassak
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Glycosylation is a universal strategy to posttranslationally modify proteins. The recently discovered arginine rhamnosylation activates the polyproline-specific bacterial translation elongation factor EF-P. EF-P is rhamnosylated on arginine
Externí odkaz:
https://doaj.org/article/e5dfd8c25c524c26a390fbfaa6131228
Autor:
Franziska Koller, Anja Hoffmann-Röder, Jürgen Lassak, Ralph Krafczyk, Lukas Bauer, Swetlana Wunder, Daniel Gast
Publikováno v:
Organicbiomolecular chemistry. 18(35)
Despite its potential importance for bacterial virulence, protein rhamnosylation has not yet been sufficiently studied. Specific anti-SerRha, anti-ThrRha and anti-AsnRha antibodies allowed the identification of previously unknown monorhamnosylated pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6742535754ff622a041e56f1e022ef30
https://pubmed.ncbi.nlm.nih.gov/32936181
https://pubmed.ncbi.nlm.nih.gov/32936181
Publikováno v:
ACS Synthetic Biology. 6:1892-1902
The analysis of the function of essential genes in vivo depends on the ability to experimentally modulate levels of their protein products. Current methods to address this are based on transcriptional or post-transcriptional regulation of mRNAs, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fcbb8ff1785936f63579289e166e5b4
https://doi.org/10.1021/acssynbio.7b00048
https://doi.org/10.1021/acssynbio.7b00048
Autor:
Kirsten Jung, Jürgen Lassak, Miriam Pfab, Pavel Kielkowski, Stephan A. Sieber, Wolfram Volkwein, Ralph Krafczyk
Canonically, tRNA synthetases charge tRNA. However, the lysyl-tRNA synthetase paralog EpmA catalyzes the attachment of (R)-β-lysine to the e-amino group of lysine 34 of the translation elongation factor P (EF-P) in Escherichia coli. This modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79287ba64a7713c3a5190ce5ebb32b81
https://mediatum.ub.tum.de/doc/1578671/document.pdf
https://mediatum.ub.tum.de/doc/1578671/document.pdf
Publikováno v:
Biological chemistryReferences. 400(11)
Post-translational modifications (PTM) are the evolutionary solution to challenge and extend the boundaries of genetically predetermined proteomic diversity. As PTMs are highly dynamic, they also hold an enormous regulatory potential. It is therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4d637e1cc2cd41cd83fdc85289082c
https://pubmed.ncbi.nlm.nih.gov/31188742
https://pubmed.ncbi.nlm.nih.gov/31188742
Autor:
Daniel Hilger, Heinrich Jung, Ralph Krafczyk, Giacomo Giacomelli, Susanne Bracher, Kamila Guérin, Yevhen Polyhach, Gunnar Jeschke
Publikováno v:
Scientific Reports, 9 (1)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Secondary transporters exist as monomers, dimers or higher state oligomers. The significance of the oligomeric state is only partially understood. Here, the significance of the trimeric state of the L-carnitine/γ-butyrobetaine antiporter CaiT of Esc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503fd3117d15bf92fa2f3b52d3cdd7ed
https://hdl.handle.net/20.500.11850/331768
https://hdl.handle.net/20.500.11850/331768
Autor:
Fang Yan, Qiuye Wu, Xing Pan, Janosch Hennig, Honggang Hu, Jürgen Lassak, Kirsten Jung, Jakub Macošek, Ralph Krafczyk, Bernd Simon, Yu-Lei Li, Shan Li, Xiang Li, Yan Zou
Publikováno v:
Chemical Science. 7:6995-7001
A previously discovered posttranslational modification strategy – arginine rhamnosylation – is essential for elongation factor P (EF-P) dependent rescue of polyproline stalled ribosomes in clinically relevant species such as Pseudomonas aeruginos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a381fe6967bf58778d2311593a6c22ae
https://doi.org/10.1039/c6sc02889f
https://doi.org/10.1039/c6sc02889f
Autor:
Elena Mankina, Marina Parr, Zhenghuan Guo, Jakub Macošek, Miriam Pfab, Pravin Kumar Ankush Jagtap, Dmitrij Frishman, Ralph Krafczyk, Kirsten Jung, Jürgen Lassak, Wolfram Volkwein, Janosch Hennig, Maximilian J. L. J. Fürst
Publikováno v:
SSRN Electronic Journal.
Tripeptides with two consecutive prolines are the shortest and most frequent sequences causing ribosome stalling. The bacterial translation elongation factor P (EF-P) relieves the arrest, allowing protein biosynthesis to continue. A seven amino acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20d4eb50924b211c5339f2370e452eb
https://doi.org/10.2139/ssrn.3280239
https://doi.org/10.2139/ssrn.3280239