Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ralph J. Abi-Habib"'
Autor:
Amira Bekdash, Manal Darwish, Zahra Timsah, Elias Kassab, Hadi Ghanem, Vicky Najjar, Marwan Ghosn, Selim Nasser, Hiba El-Hajj, Ali Bazerbachi, Shihui Liu, Stephen H. Leppla, Arthur E. Frankel, Ralph J. Abi-Habib
Publikováno v:
Translational Oncology, Vol 8, Iss 5, Pp 347-357 (2015)
In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal toxi
Externí odkaz:
https://doaj.org/article/e3a546f6ff5d4a54b4c56054715b8842
Autor:
Elias Kassab, Manal Darwish, Zahra Timsah, ShiHui Liu, Stephen H. Leppla, Arthur E. Frankel, Ralph J. Abi-Habib
Publikováno v:
Translational Oncology, Vol 6, Iss 1, Pp 25-32 (2013)
In this study, we attempt to target the mitogen-activated protein kinase (MAPK) pathway in acute myeloid leukemia (AML) cells using a recombinant anthrax lethal toxin (LeTx). LeTx consists of protective antigen (PrAg) and lethal factor (LF). PrAg bin
Externí odkaz:
https://doaj.org/article/dedcb1e311af452abb41149b646d6a01
Autor:
Massoud Vosough, Zahra Farzaneh, Fatima Taki, Oula El Atat, Ralph J. Abi-Habib, Mirvat El-Sibai, Mahsa Pourhamzeh
Publikováno v:
Human Cell. 35:23-36
The tumor microenvironment contributes significantly to tumor initiation, progression, and resistance to chemotherapy. Much of our understanding of the tumor and its microenvironment is developed using various methods of cell culture. Throughout the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed0ee4acea51b56a0473a8605cdcd9b
https://doi.org/10.1007/s13577-021-00642-9
https://doi.org/10.1007/s13577-021-00642-9
Autor:
Isabelle Fakhoury, Mirvat El-Sibai, Ralph J. Abi-Habib, Sarah Nohra, Nour El-Mais, Maria Al Haddad
Publikováno v:
Pancreas. 50:1187-1194
OBJECTIVES Pancreatic cancer is one of the most aggressive solid cancers and the fourth leading cause of cancer death in men and women. We previously showed that arginine depletion, using arginase I [HuArgI(Co)-PEG5000], selectively triggers cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65894c29364640466c0de55f2573cc3
https://doi.org/10.1097/mpa.0000000000001891
https://doi.org/10.1097/mpa.0000000000001891
Autor:
Mirvat El-Sibai, Mirna Swayden, Amira Bekdash, Oula El-Atat, Isabelle Fakhoury, Ralph J. Abi-Habib, Jamila Borjac-Natour
Publikováno v:
Human Cell. 34:152-164
Deregulating cellular energetics by reprogramming metabolic pathways, including arginine metabolism, is critical for cancer cell onset and survival. Drugs that target the specific metabolic requirements of cancer cells have emerged as promising targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb4bf60cb22fe3ba2d2c0fa5b8e2934
https://doi.org/10.1007/s13577-020-00437-4
https://doi.org/10.1007/s13577-020-00437-4
Autor:
Nathalie Khalil, Ralph J. Abi-Habib
Publikováno v:
Investigational New Drugs. 38:1236-1246
In this study, we examined the sensitivity of pancreatic cancer cells to [HuArgI (Co)-PEG5000]-induced arginine deprivation as well as the mechanisms underlying deprivation-induced cell death. [HuArgI (Co)-PEG5000]-induced arginine deprivation was cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3ec6aec4e317c16fd333d1a290eb987
https://doi.org/10.1007/s10637-019-00883-4
https://doi.org/10.1007/s10637-019-00883-4
Publikováno v:
Investigational New Drugs. 38:10-19
In this study, we assess arginine auxotrophy in ovarian cancer cells and attempt to target them using arginine deprivation induced by a pegylated recombinant human Arginase I cobalt [HuArgI (Co)-PEG5000]. Ovarian cancer cells were sensitive to [HuArg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ed732a652f02d378666e6fba5dc165
https://doi.org/10.1007/s10637-019-00756-w
https://doi.org/10.1007/s10637-019-00756-w
Publikováno v:
Journal of Ovarian Research
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-13 (2021)
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-13 (2021)
Ovarian carcinoma is the second most common malignancy of the female reproductive system and the leading cause of death from female reproductive system malignancies. Cancer cells have increased proliferation rate and thus require high amounts of amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1bff0de4b41e815d03615dfaaf754a
https://doi.org/10.1186/s13048-021-00767-3
https://doi.org/10.1186/s13048-021-00767-3
Publikováno v:
Cancer Cell International
Cancer Cell International, Vol 20, Iss 1, Pp 1-7 (2020)
Cancer Cell International, Vol 20, Iss 1, Pp 1-7 (2020)
Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginine has a versatile role in the body bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d32ff7a257302579b1ef05ba6193a3
https://pubmed.ncbi.nlm.nih.gov/32390765
https://pubmed.ncbi.nlm.nih.gov/32390765
Autor:
Rony S. Khnayzer, Zeinab El Masri, Daniel F. Azar, Ralph J. Abi-Habib, Mirvat El-Sibai, Hassib Audi, Stephanie Farhat, Farah Mahjoub
Publikováno v:
Journal of Photochemistry and Photobiology A: Chemistry. 351:59-68
A series of four ruthenium(II) complexes Ru(bp)n(bps)3-n (n = 0-3; bp = 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline; and bps = disulfonated 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline disulfonate) bearing different charges wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ace421bd0f5e95cb0916005333cbe836
https://doi.org/10.1016/j.jphotochem.2017.10.007
https://doi.org/10.1016/j.jphotochem.2017.10.007