Zobrazeno 1 - 10
of 22 243
pro vyhledávání: '"Ralph J."'
Autor:
Yutaka Furuta, Rory J. Tinker, Rizwan Hamid, Joy D. Cogan, Kimberly M. Ezell, Devin Oglesbee, Ralph J. DeBerardinis, John A. Phillips, the Undiagnosed Diseases Network
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background The number of known inherited metabolic diseases (IMDs) has been expanding, and the rate of diagnosis is improving with the development of innovative approaches including next generation sequencing (NGS). However, a substantial pr
Externí odkaz:
https://doaj.org/article/5009f7b9676c4d17bda5092fd4409131
Autor:
Ralph J. A. Maas, Janneke S. Hoogstad-van Evert, Iris M. Hagemans, Jolanda Brummelman, Diede van Ens, Paul K. J. D. de Jonge, Laura Hooijmaijers, Shweta Mahajan, Anniek B. van der Waart, Charlotte K. J. C. Hermans, Janne de Klein, Rob Woestenenk, Antonius E. van Herwaarden, Nicolaas P. M. Schaap, Somayeh Rezaeifard, Daniele V. F. Tauriello, Petra L. M. Zusterzeel, Nelleke Ottevanger, Joop H. Jansen, Willemijn Hobo, Harry Dolstra
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Natural killer (NK) cell therapy represents an attractive immunotherapy approach against recurrent epithelial ovarian cancer (EOC), as EOC is sensitive to NK cell-mediated cytotoxicity. However, NK cell antitumor activity is dampened by suppressive f
Externí odkaz:
https://doaj.org/article/fba2485f4f604077a2047c69ad71b92f
Autor:
Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro, Yi-Heng Hao, Lizbeth Perez-Castro, Pedro A. S. Nogueira, Ashley Solmonson, Ilgen Mender, Jessica A. Kilgore, Shun Fang, Isabella N. Brown, Li Li, Emily Parks, Igor Lopes dos Santos, Mahima Bhaskar, Jiwoong Kim, Yuemeng Jia, Andrew Lemoff, Nick V. Grishin, Lisa Kinch, Lin Xu, Noelle S. Williams, Jerry W. Shay, Ralph J. DeBerardinis, Hao Zhu, Maralice Conacci-Sorrell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to t
Externí odkaz:
https://doaj.org/article/6ee60b31df8e443cb81fea064aabbe4b
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to te
Externí odkaz:
https://doaj.org/article/afafdeb3c86749338da17daee958b2fe
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-8 (2024)
Abstract Background Established health-related quality of life scores do not consider both subjective and objective indices of health. We propose the subjective and objective quality of life score (SOQOL) for the comprehensive assessment of health-re
Externí odkaz:
https://doaj.org/article/52323f1e9257406fa202b772f6ec0df6
Autor:
Tari-Ann Yates, MD, Ramya Vijayakumar, PhD, Martha McGilvray, MD, Ali J. Khiabani, MD, Nicholas Razo, BS, Laurie Sinn, BSN, RN, Matthew R. Schill, MD, Nassir Marrouche, MD, FHRS, Christian Zemlin, PhD, Ralph J. Damiano, Jr., MD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 292-302 (2023)
Objectives: The mechanism by which mitral valve (MV) disease leads to atrial fibrillation (AF) remains poorly understood. Delayed-enhancement cardiac magnetic resonance imaging (DE-MRI) has been used to assess left atrial (LA) fibrosis in patients wi
Externí odkaz:
https://doaj.org/article/62f93a8ba86248a79842e74bc952e734
Autor:
Lianne Koinis, Monish Maharaj, Pragadesh Natarajan, R. Dineth Fonseka, Vinuja Fernando, Ralph J. Mobbs
Publikováno v:
Sensors, Vol 24, Iss 19, p 6484 (2024)
Background: Gait analysis is a vital tool for evaluating overall health and predicting outcomes such as mortality and cognitive decline. This study explores how normal and obese BMI categories impact gait dynamics, addressing gaps in understanding th
Externí odkaz:
https://doaj.org/article/4c6ab1097ad743b39023348307eab1e7
Autor:
Ralph J. Lehnert
Publikováno v:
Journal of Saudi Chemical Society, Vol 28, Iss 2, Pp 101827- (2024)
Context: Solubility prediction based on the general solubility equation (GSE) rests on reliable values for the isobaric heat capacity difference ΔCp,1 of the solid solute. Usually, this value is estimated with either zero or the melting entropy ΔS1
Externí odkaz:
https://doaj.org/article/10b7c4c4ee094319be2197eef99d6717
Autor:
Lea Abou Haidar, Panayotis Pachnis, Garrett K. Gotway, Min Ni, Ralph J. DeBerardinis, Markey C. McNutt
Publikováno v:
JIMD Reports, Vol 64, Iss 6, Pp 403-409 (2023)
Abstract N‐acetyl glutamate synthase (NAGS) deficiency (OMIM #: 237310) is a rare urea cycle disorder that usually presents early in life with hyperammonemia. NAGS catalyzes the synthesis of N‐acetyl glutamate (NAG) which functions as an activato
Externí odkaz:
https://doaj.org/article/f478348a0d3a4ecbad4d0dbf8afb2b97
Autor:
Tajrian Amin, William C. H. Parr, Pragadesh Natarajan, Andrew Lennox, Lianne Koinis, Ralph J. Mobbs
Publikováno v:
Surgical Techniques Development, Vol 12, Iss 4, Pp 199-210 (2023)
Introduction: Hemivertebrae are a common defect of vertebral formation, potentially resulting in debilitating congenital scoliosis and necessitating highly traumatic surgery. Virtual surgical planning (VSP) and 3D-printed patient-specific implants (P
Externí odkaz:
https://doaj.org/article/bf2dcd0616734a72adbdcb2a73da4314