Zobrazeno 1 - 10
of 454
pro vyhledávání: '"Ralph J DeBerardinis"'
Autor:
Bryn D Webb, Sara M Nowinski, Ashley Solmonson, Jaya Ganesh, Richard J Rodenburg, Joao Leandro, Anthony Evans, Hieu S Vu, Thomas P Naidich, Bruce D Gelb, Ralph J DeBerardinis, Jared Rutter, Sander M Houten
Publikováno v:
eLife, Vol 12 (2023)
Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP). Previously, we s
Externí odkaz:
https://doaj.org/article/e492c4b03a0a40868acd1fea5b29bfde
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene. The mechanisms
Externí odkaz:
https://doaj.org/article/bc53e8466ccf4687be0151852c83aa36
Autor:
Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi, Dennis R Winge, Ralph J DeBerardinis, Jared Rutter
Publikováno v:
eLife, Vol 9 (2020)
Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is poorly characterized, especially in higher eukaryotes, with the major
Externí odkaz:
https://doaj.org/article/f28d705b3f05490b91c7e479d58b568b
Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis.
Autor:
Takla Griss, Emma E Vincent, Robert Egnatchik, Jocelyn Chen, Eric H Ma, Brandon Faubert, Benoit Viollet, Ralph J DeBerardinis, Russell G Jones
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002309 (2015)
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin directly antagonizes cancer cell growth through its actions on complex I of the mitochondria
Externí odkaz:
https://doaj.org/article/a606a17a07414eb69f9a49c18a945008
Publikováno v:
Molecular Cancer Research. :OF1-OF13
Lineage plasticity has long been documented in both small cell lung cancer (SCLC) and neuroblastoma, two clinically distinct neuroendocrine (NE) cancers. In this study, we quantified the NE features of cancer as NE scores and performed a systematic c
Autor:
Sibtain Ahmed, Ayra Siddiqui, Ralph J. DeBerardinis, Min Ni, Wen Gu Lai, Feng Cai, Hieu S. Vu, Bushra Afroze
Publikováno v:
Annals of Medicine & Surgery. 85:712-717
Publikováno v:
Cancers, Vol 14, Iss 17, p 4199 (2022)
Nearly all tumors have multiple mutations in cancer-causing genes. Which of these mutations act in tandem with other mutations to drive malignancy and also provide therapeutic vulnerability? To address this fundamental question, we conducted a pan-ca
Externí odkaz:
https://doaj.org/article/b3c0edc320a142b78f6819523a0b646d
Publikováno v:
Holland‐Frei Cancer Medicine. :1-14
Autor:
Junhua Lyu, Yuxuan Liu, Lihu Gong, Mingyi Chen, Yazan F. Madanat, Yuannyu Zhang, Feng Cai, Zhimin Gu, Hui Cao, Pranita Kaphle, Yoon Jung Kim, Fatma N. Kalkan, Helen Stephens, Kathryn E. Dickerson, Min Ni, Weina Chen, Prapti Patel, Alice S. Mims, Uma Borate, Amy Burd, Sheng F. Cai, C. Cameron Yin, M. James You, Stephen S. Chung, Robert H. Collins, Ralph J. DeBerardinis, Xin Liu, Jian Xu
Publikováno v:
Cancer Discovery. 13:170-193
Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH suppresses R-2HG production in a subset of patients with AML; however, acquired
Autor:
Marisa K. Kilgour, Sarah MacPherson, Lauren G. Zacharias, Jodi LeBlanc, Sindy Babinszky, Gabrielle Kowalchuk, Scott Parks, Ryan D. Sheldon, Russell G. Jones, Ralph J. DeBerardinis, Phineas T. Hamilton, Peter H. Watson, Julian J. Lum
Publikováno v:
Nature Protocols. 17:2668-2698