Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ralph Hillman"'
Publikováno v:
Neuroscience Letters. 516:167-170
Transgenic Drosophila melanogaster carrying the human gene for alpha synuclein is an animal model for the study of Parkinson's Disease. Climbing activity in these flies is reduced as a result of the effect of this protein on the locomotor activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff7df1ef24e70825dd39f94b7633010
https://doi.org/10.1016/j.neulet.2012.03.034
https://doi.org/10.1016/j.neulet.2012.03.034
Autor:
Robert D. Meyers, Prasuna Paluru, Natalie Jerome, Ralph Hillman, Robert G. Pendleton, Jeannettee Joyner, Aseel Rasheed
Publikováno v:
Pharmacology Biochemistry and Behavior. 81:849-853
Tyrosine hydroxylase (TH), the enzyme which catalyzes the conversion of tyrosine to L-DOPA and is the rate limiting step in catecholamine biosynthesis, is genetically expressed during development in Drosophila. Null mutant alleles of the single copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fd484df411c46f4bd37395e28d9f03
https://doi.org/10.1016/j.pbb.2005.06.008
https://doi.org/10.1016/j.pbb.2005.06.008
Publikováno v:
Behavior Genetics. 32:89-94
The brain of the adult fruit fly, Drosophila melanogaster, contains tyrosine hydroxylase, the rate-limiting enzyme required for catecholamine biosynthesis, as well as dopa decarboxylase. Catecholamines, principally dopamine, are also present. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aba45d28736ff935b8293de204fa2f0
https://doi.org/10.1023/a:1015279221600
https://doi.org/10.1023/a:1015279221600
Publikováno v:
Drug Development Research. 50:142-146
Inhibition of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, by α-methyl-p-tyrosine (αMT) at media concentrations of 0.3–3.0 mM, markedly inhibited (>90%) fly reproduction and development as evidenced by progeny cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3916d491f0634445c5cda7ce93a15c1
https://doi.org/10.1002/1098-2299(200006)50:2<142::aid-ddr2>3.0.co
https://doi.org/10.1002/1098-2299(200006)50:2<142::aid-ddr2>3.0.co
Publikováno v:
Life Sciences. 59:2083-2091
Drosophila melanogaster, maintained on culture media containing alpha-methyl-p-tyrosine (alpha-MT) at millimolar levels for 7 days, fail to produce viable progeny. Lesser concentrations delay development. This effect of alpha-MT, an inhibitor of tyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5952947786d65d5ee001054700b25d6
https://doi.org/10.1016/s0024-3205(96)00562-0
https://doi.org/10.1016/s0024-3205(96)00562-0
Publikováno v:
Neuromethods ISBN: 9781617792977
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8767e10dcea662d6d35462ffb739a11
https://doi.org/10.1007/978-1-61779-298-4_4
https://doi.org/10.1007/978-1-61779-298-4_4
Autor:
Prasuna Paluru, Ralph Hillman, Jeannettee Joyner, Robert G. Pendleton, Adrian Alday, Natalie Jerome
Publikováno v:
Genesis (New York, N.Y. : 2000). 45(3)
Tyrosine hydroxylase (TH), the enzyme which catalyzes the conversion of tyrosine to L-DOPA and is rate limiting in catecholamine biosynthesis, is biochemically expressed in late stage wild-type Drosophila oocytes as well as in early embryogenesis. Nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcb8e160cc7b4d53c55eb88e190678c
https://pubmed.ncbi.nlm.nih.gov/17334989
https://pubmed.ncbi.nlm.nih.gov/17334989
Autor:
Tetsuo Ashizawa, P.C. Baier, Lore Becker, David J. Bennett, Brett Berke, Ranjita Betarbet, Kailash P. Bhatia, Francesco Bibbiani, David T. Blake, David R. Borchelt, Prodip Bose, D. Cristopher Bragg, Allison Brashear, Xandra O. Breakefield, Susan Bressman, Kathleen Burke, Nancy N. Byl, Guy A. Caldwell, Kim A. Caldwell, Songsong Cao, M. Angela Cenci, Marie-Françoise Chesselet, Carlo Colosimo, Mai Dang, Julie A. Dennis, Didier Devys, Paula Dietrich, Ioannis Dragatsis, Ian D'Souza, Rodger J. Elble, Craig Evinger, Pierre-Olivier Fernagut, Hubert H. Fernandez, John K. Fink, Sheila M. Fleming, Colin F. Fletcher, Lyle Fox, Stephen C. Fowler, Joseph H. Friedman, Felix Geser, Imad Ghorayeb, Monica Gorassini, J. Timothy Greenamyre, Philip J. Harvey, Simon J.R. Heales, Peter J. Healy, Dominique Helmlinger, Ellen J. Hess, Ralph Hillman, Gregg E. Homanics, Keith Hyland, Iyare Izevbaye, Vernice Jackson-Lewis, H.A. Jinnah, Anita J. Jurkowski, Iris S. Kassem, Michael D. Kaytor, Jason E. Kralic, Mark LeDoux, Jada Lewis, Yuqing Li, David Lieberman, Gary S. Linn, Irene Litvan, Paul J. Lombroso, Elan D. Louis, Martin Lundblad, J. Lawrence Marsh, Eileen McGowan, T.L. McKerchar, Michael Merzenich, A. Leslie Morrow, Robert Naquet, Richard Nass, Parvoneh Poorkaj Navas, Todd K. O'Buckley, Justin D. Oh, Chihiro Ohye, Harry T. Orr, Jessica L. Osterman, Leo J. Pallanck, Massimo Pandolfo, Robert G. Pendleton, Haixiang Peng, I-Feng Peng, Dianne M. Perez, Susan L. Perlman, Joel S. Perlmutter, Jeremy Petravicz, Ronald F. Pfeiffer, James O. Phillips, Michael R. Pranzatelli, Stefan-M. Pulst, Shirley Rainier, Jayaraman Rao, Angelika Richter, Farrel R. Robinson, Christopher A. Ross, Perminder S. Sachdev, Rachel Saunders-Pullman, Gerard D. Schellenberg, Gabriele Schilling, Peter R. Schofield, Nutan Sharma, Todd B. Sherer, Carmen Silva-Barrat, Harvey S. Singer, Richard Jay Smeyne, Constance Smith-Hicks, Mark Stacy, Nadia Stafanova, David G. Standaert, S.H. Subramony, Samer D. Tabbal, Kwok-Keung Tai, Floyd J. Thompson, Leslie M. Thompson, François Tison, Claudia Trenkwalder, Daniel D. Truong, Atsushi Ueda, Suvi Vartiainen, Hans Weiher, Avery H. Weiss, Gregor Karl Wenning, Alexander J. Whitworth, Peter A. Windsor, Garry Wong, Chun-Fang Wu, T.J. Zarcone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbcdf247b8c842ec8e02e3af701f31c0
https://doi.org/10.1016/b978-012088382-0/50001-3
https://doi.org/10.1016/b978-012088382-0/50001-3
Autor:
Ralph Hillman, Robert G. Pendleton
Publikováno v:
Animal Models of Movement Disorders
Behavioral observations of Drosophila are as old as some of the early genetic studies of this organism. Because the genetics of Drosophila is studied extensively, the appearance of these specific behavioral patterns in adults and larvae has almost im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83628ac9ad6bbf757c02bc0410bbfb7c
https://doi.org/10.1016/b978-012088382-0/50008-6
https://doi.org/10.1016/b978-012088382-0/50008-6
Publikováno v:
Behavior genetics. 32(2)
The brain of the adult fruit fly, Drosophila melanogaster, contains tyrosine hydroxylase, the rate-limiting enzyme required for catecholamine biosynthesis, as well as dopa decarboxylase. Catecholamines, principally dopamine, are also present. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb5d6440d6612d9200d82de4770d2b0c
https://pubmed.ncbi.nlm.nih.gov/12036114
https://pubmed.ncbi.nlm.nih.gov/12036114