Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ralph Hübner"'
Autor:
Marco Maspero, Xia Cheng, Valeska von Kiedrowski, Clelia Dallanoce, Björn Wängler, Ralph Hübner, Carmen Wängler
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 989 (2021)
In the context of hybrid multimodal imaging agents for gastrin releasing peptide receptor (GRPR) targeting, a correlation between the net charge and the receptor affinity of the agents was recently found. In particular, a decrease in in vitro GRPR bi
Externí odkaz:
https://doaj.org/article/2549ee71ccbf47aa8559d31628c35265
Autor:
Ralph Hübner, Alexa Paretzki, Valeska von Kiedrowski, Marco Maspero, Xia Cheng, Güllü Davarci, Diana Braun, Helen Damerow, Benedikt Judmann, Vasileios Filippou, Clelia Dallanoce, Ralf Schirrmacher, Björn Wängler, Carmen Wängler
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 531 (2021)
Recently, anionic charges were found to negatively influence the in vitro gastrin-releasing peptide receptor (GRPR) binding parameters of dually radioisotope and fluorescent dye labeled GRPR-specific peptide dimers. From this, the question arose if t
Externí odkaz:
https://doaj.org/article/d0175a4440d946068bdfd9f22a3e203b
Autor:
Xia Cheng, Ralph Hübner, Valeska von Kiedrowski, Gert Fricker, Ralf Schirrmacher, Carmen Wängler, Björn Wängler
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 547 (2021)
Combining two peptides addressing two different receptors to a heterobivalent peptidic ligand (HBPL) is thought to enable an improved tumor-targeting sensitivity and thus tumor visualization, compared to monovalent peptide ligands. In the case of mel
Externí odkaz:
https://doaj.org/article/47db0f7124794faaacc5e9aba9075d24
Autor:
Ralph Hübner, Valeska von Kiedrowski, Vanessa Benkert, Björn Wängler, Ralf Schirrmacher, Roland Krämer, Carmen Wängler
Publikováno v:
Pharmaceuticals, Vol 13, Iss 9, p 250 (2020)
The development of hybrid multimodal imaging synthons (MIS), carrying in addition to a chelator for radiometal labeling also a near-infrared (NIR) fluorescent cyanine dye was the aim of this work. The MIS should be introducible into biomolecules of c
Externí odkaz:
https://doaj.org/article/0d79519c77a746e3ac8b11d30bdf0598
Autor:
A. A. Bardin, Mojtaba Javaheri Rahim, Andrej Pustogow, Marc Scheffler, Ralph Hübner, Martin Dressel, Kazushi Kanoda, John A. Schlueter, Björn Miksch
Publikováno v:
Science. 372:276-279
Geometrical frustration, quantum entanglement and disorder may prevent long-range order of localized spins with strong exchange interactions, resulting in a novel state of matter. $\kappa$-(BEDT-TTF)$_2$-Cu$_2$(CN)$_3$ is considered the best approxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620cc33f087c145139b0a5c12fef5858
https://doi.org/10.1126/science.abc6363
https://doi.org/10.1126/science.abc6363
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
We describe multimodal imaging probes for gastrin‐releasing peptide receptor (GRPR)‐specific targeting suited for positron emission tomography and optical imaging (PET/OI), consisting of PESIN (PEG3‐BBN7‐14) dimers connected to multimodal ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffce6b57ff5d4fe9614c92727d5cb1a
https://doi.org/10.1002/chem.202002386
https://doi.org/10.1002/chem.202002386
Publikováno v:
ChemMedChem. 17(8)
In the present study we describe and explain an aberrant behavior in terms of receptor binding profile of a fluorescein-based multimodal imaging agent for gastrin releasing peptide receptor (GRPR) visualization by elucidating a chelating mechanism on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7882e012d2f69456917a5eb8a47d689
https://pubmed.ncbi.nlm.nih.gov/35137522
https://pubmed.ncbi.nlm.nih.gov/35137522
Autor:
Ralph Hübner, Stefan Hövel
Publikováno v:
Brand Evolution ISBN: 9783658359157
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::865a01535cb8919d631a24e9e5c75cf6
https://doi.org/10.1007/978-3-658-35916-4_10
https://doi.org/10.1007/978-3-658-35916-4_10
Autor:
Helen Damerow, Ralph Hübner, Benedikt Judmann, Ralf Schirrmacher, Björn Wängler, Gert Fricker, Carmen Wängler
Publikováno v:
Cancers, Vol 13, Iss 6349, p 6349 (2021)
Cancers; Volume 13; Issue 24; Pages: 6349
Cancers; Volume 13; Issue 24; Pages: 6349
In this work, five different chelating agents, namely DFO, CTH-36, DFO*, 3,4,3-(LI-1,2-HOPO) and DOTA-GA, were compared with regard to the relative kinetic inertness of their corresponding 89Zr complexes to evaluate their potential for in vivo applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f99390f36ee7111d0d3fdbaed2d84ae
https://www.mdpi.com/2072-6694/13/24/6349
https://www.mdpi.com/2072-6694/13/24/6349
Autor:
Simon, Lindner, Henning, Rudolf, Giovanna, Palumbo, Rosel, Oos, Melissa, Antons, Ralph, Hübner, Peter, Bartenstein, Ralf, Schirrmacher, Björn, Wängler, Carmen, Wängler
Publikováno v:
Bioorganicmedicinal chemistry letters. 48
Receptor-specific peptides labeled with positron emitters play an important role in the clinical imaging of several malignancies by positron emission tomography (PET). Radiolabeled heterobivalent bispecific peptidic ligands (HBPLs) can target more th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae0b8e759b4c2077f255213152b47bf9
https://pubmed.ncbi.nlm.nih.gov/34217827
https://pubmed.ncbi.nlm.nih.gov/34217827