Zobrazeno 1 - 10
of 1 360
pro vyhledávání: '"Ralph H, Hruban"'
New in the Differential Diagnosis in Surgical Pathology series, this abundantly illustrated title helps you systematically solve tough diagnostic challenges in pancreatic and biliary pathology. It uses select images of clinical and pathological fin
Autor:
Hirokazu Kimura, Raymond M Paranal, Neha Nanda, Laura D Wood, James R Eshleman, Ralph H Hruban, Michael G Goggins, Alison P Klein, The Familial Pancreatic Cancer Genome Sequencing Project, Nicholas J Roberts
Publikováno v:
eLife, Vol 11 (2022)
Pathogenic germline CDKN2A variants are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC). CDKN2A variants of uncertain significance (VUSs) are reported in up to 4.3% of patients with PDAC and result in significant uncertai
Externí odkaz:
https://doaj.org/article/9d870a3f89c84fea8ab4363964ed5f55
Autor:
Michaël Noë, Noushin Niknafs, Catherine G. Fischer, Wenzel M. Hackeng, Violeta Beleva Guthrie, Waki Hosoda, Marija Debeljak, Eniko Papp, Vilmos Adleff, James R. White, Claudio Luchini, Antonio Pea, Aldo Scarpa, Giovanni Butturini, Giuseppe Zamboni, Paola Castelli, Seung-Mo Hong, Shinichi Yachida, Nobuyoshi Hiraoka, Anthony J. Gill, Jaswinder S. Samra, G. Johan A. Offerhaus, Anne Hoorens, Joanne Verheij, Casper Jansen, N. Volkan Adsay, Wei Jiang, Jordan Winter, Jorge Albores-Saavedra, Benoit Terris, Elizabeth D. Thompson, Nicholas J. Roberts, Ralph H. Hruban, Rachel Karchin, Robert B. Scharpf, Lodewijk A. A. Brosens, Victor E. Velculescu, Laura D. Wood
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasiv
Externí odkaz:
https://doaj.org/article/3f4f6cf36e134a3094f1e12eeacabd74
Autor:
Laura M. Wake MD, Derek B. Allison MD, Alisha D. Ware MD, Jody E. Hooper MD, Alex S. Baras MD, PhD, Evan M. Bloch MBChB, MS, William Clarke PhD, Kathleen H. Burns MD, PhD, Karen S. Sfanos MS, PhD, Michael J. Borowitz MD, PhD, Charles Steenbergen MD, PhD, Ralph H. Hruban MD, Marissa J. White MD
Publikováno v:
Academic Pathology, Vol 8 (2021)
Pathologists who enter the workforce must have a diverse skill set beyond that of clinical diagnostics alone. Anticipating this need, the Johns Hopkins Pathology Residency Program developed Special Expertise Tracks to enhance training in relevant sub
Externí odkaz:
https://doaj.org/article/a86339f24c504feabc4054c257fe2eee
Autor:
Emily K.W. Lo, Brian M. Mears, H. Carlo Maurer, Adrian Idrizi, Kasper D. Hansen, Elizabeth D. Thompson, Ralph H. Hruban, Kenneth P. Olive, Andrew P. Feinberg
Publikováno v:
Cancer Research. :OF1-OF12
Pancreatic ductal adenocarcinoma (PDAC) is believed to arise from the accumulation of a series of somatic mutations and is also frequently associated with pancreatic intraepithelial neoplasia (PanIN) lesions. However, there is still debate as to whet
Clinical and radiologic examinations cannot reliably distinguish benign or inflammatory pancreatic disease from carcinoma. The increased use of pancreatic fine needle aspiration (FNA) along with advances in imaging techniques and the introduction of
Autor:
Maryam A. L. Eissa, Lane Lerner, Eihab Abdelfatah, Nakul Shankar, Joseph K. Canner, Nesrin M. Hasan, Vesal Yaghoobi, Barry Huang, Zachary Kerner, Felipe Takaesu, Christopher Wolfgang, Ruby Kwak, Michael Ruiz, Matthew Tam, Thomas R. Pisanic, Christine A. Iacobuzio-Donahue, Ralph H. Hruban, Jin He, Tza-Huei Wang, Laura D. Wood, Anup Sharma, Nita Ahuja
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-10 (2019)
Abstract Background Despite improvements in cancer management, most pancreatic cancers are still diagnosed at an advanced stage. We have recently identified promoter DNA methylation of the genes ADAMTS1 and BNC1 as potential blood biomarkers of pancr
Externí odkaz:
https://doaj.org/article/5ee67cadac9942d2bebf4c36ab2fd50c
Autor:
Gary L. Gallia, Ming Zhang, Yi Ning, Michael C. Haffner, Denise Batista, Zev A. Binder, Justin A. Bishop, Christine L. Hann, Ralph H. Hruban, Masaru Ishii, Alison P. Klein, Douglas D. Reh, Lisa M. Rooper, Vafi Salmasi, Rafael J. Tamargo, Qing Wang, Tara Williamson, Tianna Zhao, Ying Zou, Alan K. Meeker, Nishant Agrawal, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Chetan Bettegowda
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.
Externí odkaz:
https://doaj.org/article/666203899eb144b58109b82017f4bbe7
Autor:
Ashley L. Kiemen, Alexander Ioannis Damanakis, Alicia M. Braxton, Jin He, Daniel Laheru, Elliot K. Fishman, Patrick Chames, Cristina Almagro Pérez, Pei-Hsun Wu, Denis Wirtz, Laura D. Wood, Ralph H. Hruban
Publikováno v:
Med
Med, 2023, 4 (2), pp.75-91. ⟨10.1016/j.medj.2022.11.009⟩
Med, 2023, 4 (2), pp.75-91. ⟨10.1016/j.medj.2022.11.009⟩
International audience; Pancreatic cancer is currently the third leading cause of cancer death in the United States. The clinical hallmarks of this disease include abdominal pain that radiates to the back, the presence of a hypoenhancing intrapancrea
Publikováno v:
Cytopathology. 34:254-258