Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ralph Grassmann"'
Publikováno v:
Viruses, Vol 3, Iss 8, Pp 1439-1459 (2011)
The phenotype of HTLV-1-transformed CD4+ T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory recepto
Externí odkaz:
https://doaj.org/article/c069eb9370f1400d9afa23f877a5f955
Publikováno v:
Viruses, Vol 3, Iss 8, Pp 1439-1459 (2011)
Viruses
Viruses
The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96ce73119e6ea3d56bba520bec9bddf
http://www.mdpi.com/1999-4915/3/8/1439/
http://www.mdpi.com/1999-4915/3/8/1439/
Publikováno v:
Blood. 117:3609-3612
Oncogenic transformation of CD4+ T cells by human T-cell lymphotropic virus type 1 (HTLV-1) is understood as the initial step to adult T-cell leukemia/lymphoma, a process that is mainly initiated by perturbation of cellular signaling by the viral Tax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5499929582092814e1ea4e48a97a8d
https://doi.org/10.1182/blood-2010-09-305805
https://doi.org/10.1182/blood-2010-09-305805
Publikováno v:
Journal of General Virology. 89:2788-2798
The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein transforms human lymphocytes and is critical for the pathogenesis of HTLV-1-induced adult T-cell leukaemia. In HTLV-transformed cells, Tax upregulates interleukin (IL)-13, a cytokine wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d129d7a206229bdee5ae45e9dbd5ad0
https://doi.org/10.1099/vir.0.2008/003699-0
https://doi.org/10.1099/vir.0.2008/003699-0
Autor:
Andrea K. Kress, Ralph Grassmann, Graham P. Taylor, Charles R. M. Bangham, Klemens Pichler, Juliane Gentzsch, Tarek Kattan
Publikováno v:
Blood. 111:4741-4751
Human T-cell leukemia virus type 1 (HTLV-1), the cause of adult T-cell leukemia, stimulates the growth of infected T cells in cultures and in nonleukemic patients. In the latter, HTLV-1 is found in long-term persisting T-cell clones. The persistence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decc4d8ab4d509206a72f4dcc5a8977c
https://doi.org/10.1182/blood-2007-10-115220
https://doi.org/10.1182/blood-2007-10-115220
Autor:
Susan J. Marriott, Ralph Grassmann, Charles R. M. Bangham, Masao Matsuoka, Patrick L. Green, Mari Kannagi, Kuan-Teh Jeang, Toshiki Watanabe
Publikováno v:
Cancer Research. 67:10638-10641
Thirty years ago, in 1977, a new clinical entity called adult T-cell leukemia (ATL) was described in Japan by Takatsuki and colleagues. Subsequently, Poiesz, Ruscetti, Gallo, and coworkers; and Yoshida, Miyoshi, Hinuma, and colleagues isolated a huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667993671fe9807bd31e750e791df65b
https://doi.org/10.1158/0008-5472.can-07-2587
https://doi.org/10.1158/0008-5472.can-07-2587
Autor:
Katrin Silbermann, Ralph Grassmann
Publikováno v:
Signal Transduction. 7:34-52
Human T cell leukemia virus type 1 (HTLV-1), a delta-retrovirus, causes an aggressive malignancy of T lymphocytes called adult T cell leukemia/lymphoma and stimulates permanent cell growth in culture. The virus encodes a nonstructural regulatory prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42b04f63151c5021d294bd848085f8e
https://doi.org/10.1002/sita.200600119
https://doi.org/10.1002/sita.200600119
Autor:
Katja Wäldele, Katrin Silbermann, Bryan R. Cullen, Grit Schneider, Ralph Grassmann, Tobias Ruckes
Publikováno v:
Blood. 107:4491-4499
Human T cell leukemia virus type 1 (HTLV-1), the cause of adult T cell leukemia (ATL), induces clonal expansion of infected T-cells in nonleukemic individuals and immortalizes T cells in vitro. The resistance against apoptotic stimuli of these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ced80f53b453fb2ef76358cd5b61d1b
https://doi.org/10.1182/blood-2005-08-3138
https://doi.org/10.1182/blood-2005-08-3138
Publikováno v:
Blood. 98:1150-1159
Adult T-cell leukemia (ATL) is an aggressive malignancy of CD4(+) T cells caused by the human T-cell leukemia virus type 1 (HTLV-1). The viral leukemogenesis is critically dependent on its oncoprotein Tax because the protein as well as the virus can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4db59001aedcbb97549f045c4f2ab
https://doi.org/10.1182/blood.v98.4.1150
https://doi.org/10.1182/blood.v98.4.1150
Autor:
Armin Bender, Ralph Grassmann, Annette Menke, Markus Krumbholz, Gerold Schuler, Erich Hoffmann, Gerd Hobom, Isolde Strobel, P. Rod Dunbar, Alexander Steinkasserer
Publikováno v:
Human Gene Therapy. 11:2207-2218
Dendritic cells (DCs) are the most potent inducers of immune reactions. Genetically modified DCs, which express tumor-associated antigens (TAA), can efficiently induce antitumor immunity and thus have a high potential as tools in cancer therapy. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419d3c9c17891d255f54f74768c98801
https://doi.org/10.1089/104303400750035735
https://doi.org/10.1089/104303400750035735