Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ralph Gingell"'
Publikováno v:
Regulatory Toxicology and Pharmacology. 55:205-218
It is proposed that metabolism of several structurally-related chemicals by CYP2F isoforms of the cytochromes P450 family results in a cytotoxicity-driven mode of action in organs high in CYP2F; namely, CYP2F2 in nasal and lung tissue in mice and CYP
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 83:459-476
Published studies for reproductive and developmental toxicity conducted with isopropanol have been conducted by the inhalation and oral gavage routes of administration. Interpretation of the data from these studies has resulted in discussions regardi
Autor:
Ralph Gingell, Francis H. Kruszewski, Neil K. Snyder, Fred A. Heitfeld, Michael K. Robinson, Mark E. Blazka, Phillip L. Casterton, Jenan Al-Atrash, David Mallon, Judith E. Swanson
Publikováno v:
Food and Chemical Toxicology. 43:1703-1712
Predictive skin irritation test methods, which do not require use of animals, are needed for the pre-market assessment of detergent formulations. The utility of a novel and ethical human acute skin irritation patch test method, originally developed f
Autor:
George Cruzan, Kenneth E. McMartin, Richard A. Corley, Jos J. W. M. Mertens, William M. Snellings, Ralph Gingell, James A. Deyo, Gordon C. Hard
Publikováno v:
Toxicological Sciences. 81:502-511
Ethylene glycol (CAS RN 107-21-1) can cause kidney toxicity via the formation of calcium oxalate crystals in a variety of species, including humans. Numerous repeated dose studies conducted in rats have indicated that male rats are more susceptible t
Autor:
Ralph Gingell, D. C. Topping, M. D. Nemec, E. J. Rauckman, K. L. Pavkov, S. B. Harris, J. A. Pitt
Publikováno v:
International Journal of Toxicology. 23:127-143
To evaluate whether methyl isobutyl ketone (MIBK) affects reproductive performance, a two-generation reproduction study was conducted. MIBK was administered to 30 Sprague-Dawley rats/sex/group via whole-body inhalation at concentrations of 0, 500, 10
Publikováno v:
Drug and Chemical Toxicology. 23:327-338
This study was conducted to provide screening information concerning the potential systemic, reproductive and developmental toxicity of 1-hexene when administered orally, by gavage, to male and female rats using a modified OECD 421 protocol. 1-Hexene
Publikováno v:
International Journal of Toxicology. 19:27-32
1,3-Propanediol was a specialty chemical that, due to a novel manufacturing process, is now commercially available in large quantities. Its subchronic toxicity has been evaluated in rats, with special emphasis on potential male reproductive effects.
Publikováno v:
Food and Chemical Toxicology. 36:825-829
Acute toxicity values, such as oral and percutaneous LD50s, are often used as the basis for classifying chemicals into toxicity categories, and their subsequent regulation. Such values obtained for ethylene glycol mono-n-butyl ether (EGBE; 2-butoxyet
Publikováno v:
International Journal of Toxicology. 17:1-22
These studies were conducted to evaluate the potential for repeated subchronic administration of triethylene glycol monomethyl ether (TGME) to produce systemic toxicity in the rat following dermal application, and neurotoxicity in the rat following p
Autor:
Ralph Gingell, Cheryle C. Lu
Publikováno v:
Journal of the American College of Toxicology. 10:477-486
The mammalian toxicity of a C9–11 linear primary alcohol 6-mole ethoxylate, used in aqueous cleaning formulations, has been evaluated. The rat acute oral LD50 was 1.4 g/kg, and the rabbit acute dermal LD50 was greater than 2 g/kg. Undiluted materia