Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ralph E. Vatner"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
In this review, we cover the current understanding of how radiation therapy, which uses ionizing radiation to kill cancer cells, mediates an anti-tumor immune response through the cGAS-STING pathway, and how STING agonists might potentiate this. We e
Externí odkaz:
https://doaj.org/article/41b0141154be4d0d891bc7dcef2d199f
Autor:
Jackson Howell, Christopher Dandoy, Jordan M. Wright, Lionel Chow, Ayman El‐Sheikh, Mukund Dole, Ralph E. Vatner, Kambiz Kamian
Publikováno v:
Cancer Reports, Vol 5, Iss 8, Pp n/a-n/a (2022)
Abstract Background Intracranial germ cell tumors (GCTs) comprise 3%–5% of pediatric primary central nervous system (CNS) tumors in Western countries. Though they are related in embryonic origin to gonadal GCTs, which are considered highly treatabl
Externí odkaz:
https://doaj.org/article/67492de0375e44518123f55adae72dbc
Autor:
Michael T. Williams, Chiho Sugimoto, Samantha L. Regan, Emily M. Pitzer, Adam L. Fritz, Anthony E. Mascia, Mathieu Sertorio, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of cognitive deficits from conventional proton exposure is needed. We developed a model empha
Externí odkaz:
https://doaj.org/article/5d32edd717014b9596a855396e69d6d1
Publikováno v:
Clin Oncol (R Coll Radiol)
Ionising radiation causes secondary tumours and/or enduring cognitive deficits, especially in children. Proton radiotherapy reduces exposure of the developing brain in children but may still cause some lasting effects. Recent observations show that u
Autor:
Michael T. Williams, Chiho Sugimoto, Samantha L. Regan, Emily M. Pitzer, Adam L. Fritz, Mathieu Sertorio, Anthony E. Mascia, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees
Publikováno v:
PloS one. 17(9)
Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates (~1 Gy/s), but further preclinical dat
Autor:
Anthony Sabulski, Ralph E. Vatner, Bernadette L. Koch, Allison L. Bartlett, Benjamin Mizukawa, Christine L Phillips
Publikováno v:
Journal of Pediatric Hematology/Oncology. 43:e494-e497
Risk stratification and appropriate treatment selection for children with precursor B-acute lymphoblastic leukemia (B-ALL) have improved outcomes. We report the case of a 4-year-old male with a lymphomatous cavernous sinus mass, a previously undescri
Autor:
Jackson Neal Howell, Lionel M L Chow, Christopher E. Dandoy, Mukund Dole, Kambiz Kamian, Ralph E. Vatner, Jordan M Wright, Ayman El-Sheikh
Publikováno v:
Cancer Reports. 5
Background Intracranial germ cell tumors (GCTs) comprise 3%-5% of pediatric primary central nervous system (CNS) tumors in Western countries. Though they are related in embryonic origin to gonadal GCTs, which are considered highly treatable with cisp
Autor:
Ralph E. Vatner, Edith M. Janssen
Publikováno v:
Molecular Immunology
Molecular immunology
Molecular immunology
Cancer and the immune system are intimately related. Much of the bulk of tumors is comprised of stromal leukocytes with immune functions, which serve to both promote and inhibit tumor growth, invasion and metastasis. The T lymphocytes of the adaptive
Autor:
Arnold C. Paulino, Elizabeth A. Weyman, Ralph E. Vatner, Andrzej Niemierko, David H. Ebb, Mary S. Huang, Torunn I. Yock, Shannon M. MacDonald, Claire P. Goebel, Robin M. Jones, David R. Grosshans, Nancy J. Tarbell, Takara L. Stanley, Madhusmita Misra, Anita Mahajan
Publikováno v:
Journal of Clinical Oncology. 36:2854-2862
Purpose There are sparse data defining the dose response of radiation therapy (RT) to the hypothalamus and pituitary in pediatric and young adult patients with brain tumors. We examined the correlation between RT dose to these structures and developm
Autor:
Charles David James, John A. Kalapurakal, Ralph E. Vatner, Peter J. Houghton, Vythialingam Sathiaseelan, Kathryn Bondra
Publikováno v:
Pediatric Blood & Cancer. 68
Despite radiation therapy (RT) being an integral part of the treatment of most pediatric cancers and the recent discovery of novel molecular-targeted agents (MTAs) in this era of precision medicine with the potential to improve the therapeutic ratio