Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Ralph E. Parchment"'
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Autor:
Sebastian Schmid, Zachary R. Russell, Alex Shimura Yamashita, Madeline E. West, Abigail G. Parrish, Julia Walker, Dmytro Rudoy, James Z. Yan, David C. Quist, Betemariyam N. Gessesse, Neriah Alvinez, Kimberly D. Hill, Larry W. Anderson, Patrick J. Cimino, Debra K. Kumasaka, Ralph E. Parchment, Eric C. Holland, Frank Szulzewsky
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114829- (2024)
Summary: Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine
Externí odkaz:
https://doaj.org/article/4470af9805e444e2b122261c594c9aa1
Autor:
Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTHistone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such t
Externí odkaz:
https://doaj.org/article/76cdf0bfff0e453b87e8b5bd10e9b649
Autor:
Zibo Chen, Lin Zheng, Yulong Chen, Xiuxia Liu, Masanori Kawakami, Lisa Maria Mustachio, Jason Roszik, Katherine V. Ferry-Galow, Ralph E. Parchment, Xin Liu, Thorkell Andresson, Gerard Duncan, Jonathan M. Kurie, Jaime Rodriguez-Canales, Xi Liu, Ethan Dmitrovsky
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 265-280 (2022)
Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of cancer mortality. We previously reported increased ubiquitin-specific peptidase 18 (USP18)
Externí odkaz:
https://doaj.org/article/89c6b8309f354ba2877fae72139376be
Autor:
Yulia Y. Tyurina, Alexandr A. Kapralov, Vladimir A. Tyurin, Galina Shurin, Andrew A. Amoscato, Dhivyaa Rajasundaram, Hua Tian, Yuri L. Bunimovich, Yulia Nefedova, William G. Herrick, Ralph E. Parchment, James H. Doroshow, Hulya Bayir, Apurva K. Srivastava, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102650- (2023)
Growing cancer cells effectively evade most programs of regulated cell death, particularly apoptosis. This necessitates a search for alternative therapeutic modalities to cause cancer cell's demise, among them – ferroptosis. One of the obstacles to
Externí odkaz:
https://doaj.org/article/456757eed77a40cd9dc6f115fa83021a
Autor:
Ralph E. Parchment, James H. Doroshow, Robert J. Kinders, John J. Wright, Donald P. Bottaro, James O. Peggins, Melanie A. Simpson, Dane Liston, Joseph M. Covey, Jeevan Prasaad Govindharajulu, Melinda G. Hollingshead, Apurva K. Srivastava
The development of molecularly targeted agents has benefited from use of pharmacodynamic markers to identify “biologically effective doses” (BED) below MTDs, yet this knowledge remains underutilized in selecting dosage regimens and in comparing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::505a5b903a222864e5ba59e4d5938957
https://doi.org/10.1158/1535-7163.c.6538198.v1
https://doi.org/10.1158/1535-7163.c.6538198.v1
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
This document includes Supplementary Methods, validation data (Figures S1 and S2), complete PD data sets (Figures S3-S7), and Supplementary Tables detailing statistical analyses and assay validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2112c24bc490ca09fb4765d6616478c1
https://doi.org/10.1158/1535-7163.22520812.v1
https://doi.org/10.1158/1535-7163.22520812.v1
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4c9076603dbbe6d0c3610e28659c6
https://doi.org/10.1158/1535-7163.c.6542791
https://doi.org/10.1158/1535-7163.c.6542791
Autor:
Ralph E. Parchment, James H. Doroshow, Robert J. Kinders, John J. Wright, Donald P. Bottaro, James O. Peggins, Melanie A. Simpson, Dane Liston, Joseph M. Covey, Jeevan Prasaad Govindharajulu, Melinda G. Hollingshead, Apurva K. Srivastava
This file contains Supplementary Tables S1 and S2 (pharmacokinetic data) and Supplementary Figures S1 (chemical structures of the four MET kinase inhibitors examined in this study), S2 (pharmacokinetic and pharmacodynamic data for ARQ197), S3 (body w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ec35b7c0ae4ebb7ab8a9914e735d7f
https://doi.org/10.1158/1535-7163.22505818
https://doi.org/10.1158/1535-7163.22505818
Autor:
Robert J. Kinders, James H. Doroshow, Ralph E. Parchment, Shivaani Kummar, Alice Chen, Melinda G. Hollingshead, Scott M. Lawrence, Angie B. Dull, Allison M. Barrett, Deborah F. Wilsker
Purpose:We sought to examine the pharmacodynamic activation of the DNA damage response (DDR) pathway in tumors following anticancer treatment for confirmation of target engagement.Experimental Design:We evaluated the time course and spatial activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f94eb706d8d7d44b5475009f3e8c0c
https://doi.org/10.1158/1078-0432.c.6527162
https://doi.org/10.1158/1078-0432.c.6527162
Autor:
Ralph E. Parchment, James H. Doroshow, Shivaani Kummar, Joseph E. Tomaszewski, Naoko Takebe, Robert J. Kinders, James P. Mapes, Dominic Esposito, Jennifer Donohue, Jeevan Prasaad Govindharajulu, Eric Damour, Adam Layhee, Melinda G. Hollingshead, Laurie Stephen, Soumya Jaganathan, Apurva K. Srivastava
This file contains supplemental materials and methods describing protein calibrator preparation and pre-analytical variability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b0350249350c5cb055684ca5039696
https://doi.org/10.1158/1078-0432.22459986
https://doi.org/10.1158/1078-0432.22459986