Výsledky vyhledávání - "Ralph E. Hurd"

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle

Autor: David Bendahan, Dirk Mayer, Peter J. Havel, James L. Graham, Daniel M. Spielman, Thomas Jue, Ralph E. Hurd, Jae Mo Park, Sonal Josan, Youngran Chung

Publikováno v: Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, 2021, 473 (11), pp.1761-1773. ⟨10.1007/s00424-021-02613-3⟩
Pflugers Arch
Pflugers Archiv : European journal of physiology, vol 473, iss 11

The role of pyruvate dehydrogenase in mediating lipid-induced insulin resistance stands as a central question in the pathogenesis of type 2 diabetes mellitus. Many researchers have invoked the Randle hypothesis to explain the reduced glucose disposal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc79aa21dda289bea082c308695f915
https://doi.org/10.1007/s00424-021-02613-3

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Proton magnetic resonance spectroscopy assessment of neonatal brain metabolism during cardiopulmonary bypass surgery

Autor: Daniel M. Spielman, Meng Gu, Ralph E. Hurd, R. Kirk Riemer, Kenichi Okamura, Frank L. Hanley

Publikováno v: NMR Biomed

Here, we report on the development and performance of a robust 3-T single-voxel proton magnetic resonance spectroscopy ((1)H MRS) experimental protocol and data analysis pipeline for quantifying brain metabolism during cardiopulmonary bypass (CPB) su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bae9a72feb80707f7f2b0fdde22c10a
https://doi.org/10.1002/nbm.4752

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Association between Anterior Cingulate Neurochemical Concentration and Individual Differences in Hypnotizability

Autor: Laima Baltusis, Hua Wu, Katy H. Stimpson, Nolan Willliams, Meng Gu, Ralph E. Hurd, Danielle D. DeSouza, David Spiegel, Matthew D. Sacchet, David C. Yeomans

Publikováno v: Cereb Cortex

Hypnosis is the oldest form of Western psychotherapy and a powerful evidence-based treatment for numerous disorders. Hypnotizability is variable between individuals; however, it is a stable trait throughout adulthood, suggesting that neurophysiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1311941c4096755c386999e5f40b595
https://doi.org/10.1093/cercor/bhz332

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Altered Neurotransmitter Ratio in the Prefrontal Cortex is Associated with Pain in Fibromyalgia Syndrome

Autor: Naushaba Khan, Heer Amin, Daniel M. Spielman, Azeezat Azeez, Afik Faerman, David C. Yeomans, Claudia Tischler, Meng Gu, James Bishop, David Spiegel, Laima Baltusis, Nolan R. Williams, Andrew Geoly, Ralph E. Hurd, Adi Maron-Katz, Matthew D. Sacchet

The central mechanisms underlying fibromyalgia syndrome (FMS) remain undetermined. The dorsolateral prefrontal cortex (DLPFC) is particularly relevant to FMS because it is implicated in cognitive, affective, and top-down pain regulation. Imbalances i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e5e311dec0a6291ddc2332f828a725
https://doi.org/10.1101/2021.10.28.21265618

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Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Autor: Carolyn E. Mountford, Arend Heerschap, Ramon Gonzalez, Dieter J. Meyerhoff, Rolf Gruetter, Martin O. Leach, Nouha Salibi, Peter B. Barker, Stephan Gruber, Cristina Cudalbu, In-Young Choi, Ivan Tkáč, Alberto Bizzi, Hoby P. Hetherington, Harish Poptani, Alexander P. Lin, Rakesh Gupta, Daniel B. Vigneron, Stefan Posse, Petra Susan Hüppi, Dennis W. J. Klomp, Małgorzata Marjańska, Kejal Kantarci, Risto A. Kauppinen, Ralph E. Hurd, Ovidiu C. Andronesi, Kevin M. Brindle, Tom W. J. Scheenen, Franklyn A. Howe, Ulrike Dydak, Martin Wilson, Patrick J. Bolan, Ralph Noeske, Brian J. Soher, Paul G. Mullins, Roland Kreis, Robert Bartha, Julie W Pan, Gülin Öz, Ian C.P. Smith, Andrew A. Maudsley, Eva-Maria Ratai, Andrew C. Peet, James B. Murdoch, Anke Henning, Marijn J. Kruiskamp, Sarah J. Nelson, Uzay E. Emir, Peter R. Luijten

Publikováno v: Medical Biophysics Publications
Magnetic Resonance in Medicine, 82, 527-550
Magnetic Resonance in Medicine, 82(2), 527. John Wiley and Sons Inc.
Magnetic Resonance in Medicine, Vol. 82, No 2 (2019) pp. 527-550
Wilson, Martin; Andronesi, Ovidiu; Barker, Peter B; Bartha, Robert; Bizzi, Alberto; Bolan, Patrick J; et al.(2019). Methodological consensus on clinical proton MRS of the brain: Review and recommendations.. Magnetic resonance in medicine. doi: 10.1002/mrm.27742. UCSF: Retrieved from: http://www.escholarship.org/uc/item/15m1p6w0
Magnetic Resonance in Medicine
Wilson, M, Andronesi, O, Barker, P B, Bartha, R, Bizzi, A, Bolan, P J, Brindle, K M, Choi, I-Y, Cudalbu, C, Dydak, U, Emir, U E, Gonzalez, R G, Gruber, S, Gruetter, R, Gupta, R K, Heerschap, A, Henning, A, Hetherington, H P, Huppi, P S, Hurd, R E, Kantarci, K, Kauppinen, R A, Klomp, D W J, Kreis, R, Kruiskamp, M J, Leach, M O, Lin, A P, Luijten, P R, Marjańska, M, Maudsley, A A, Meyerhoff, D J, Mountford, C E, Mullins, P G, Murdoch, J B, Nelson, S J, Noeske, R, Öz, G, Pan, J W, Peet, A C, Poptani, H, Posse, S, Ratai, E-M, Salibi, N, Scheenen, T W J, Smith, I C P, Soher, B J, Tkáč, I, Vigneron, D B & Howe, F A 2019, ' Methodological consensus on clinical proton MRS of the brain : Review and recommendations ', Magnetic Resonance in Medicine, vol. 82, no. 2, pp. 527-550 . https://doi.org/10.1002/mrm.27742
Magnetic resonance in medicine, vol 82, iss 2
Magnetic Resonance in Medicine, 82, 2, pp. 527-550

Proton Magnetic Resonance Spectroscopy ((1)H MRS) provides non-invasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Whilst most modern clinical MR scanners support MRS capab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05781c734b455a0cd3ad08cacb9b706f
https://doi.org/10.1002/mrm.27742

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Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization

Autor: Jeeva Munasinghe, Peter L. Choyke, Galen D. Reed, Jeffrey R. Brender, Murali C. Krishna, Jan Henrik Ardenkjær-Larsen, James B. Mitchell, Ralph E. Hurd, Keita Saito, Shun Kishimoto, Kazutoshi Yamamoto, Albert P. Chen, Tomohiro Seki, Nobu Oshima, Hellmut Merkle

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Brender, J R, Kishimoto, S, Merkle, H, Reed, G, Hurd, R E, Chen, A P, Ardenkjær-Larsen, J H, Munasinghe, J, Saito, K, Seki, T, Oshima, N, Yamamoto, K, Choyke, P L, Mitchell, J & Krishna, M C 2019, ' Dynamic Imaging of Glucose and Lactate Metabolism by C-13-MRS without Hyperpolarization ', Scientific Reports, vol. 9, no. 1, 3410 . https://doi.org/10.1038/s41598-019-38981-1

Metabolic reprogramming is one of the defining features of cancer and abnormal metabolism is associated with many other pathologies. Molecular imaging techniques capable of detecting such changes have become essential for cancer diagnosis, treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96facdedfd8ba3ce49e0419474af6ae
http://link.springer.com/article/10.1038/s41598-019-38981-1

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PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose

Autor: Ralph E. Hurd, Daniel M. Spielman, Matthew B. Boxer, Brian K. Rutt, Jae Mo Park, Kyle R. Brimacombe, Tarik F. Massoud, Sui Seng Tee

Publikováno v: Oncotarget

// Sui Seng Tee 1, 5, * , Jae Mo Park 1, 6, 7, * , Ralph E. Hurd 2 , Kyle R. Brimacombe 3, 4 , Matthew B. Boxer 3 , Tarik F. Massoud 1 , Brian K. Rutt 1 and Daniel M. Spielman 1 1 Department of Radiology, Stanford University, Stanford, CA, USA 2 Appl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310270ded1c5628023011252528202a4
https://doi.org/10.18632/oncotarget.19630

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GABA editing with macromolecule suppression using an improved MEGA-SPECIAL sequence

Autor: Laima Baltusis, Daniel M. Spielman, Frederick T. Chin, Meng Gu, Roeland Hancock, Ralph Noeske, Matthew D. Sacchet, Ralph E. Hurd, Ian H. Gotlib

Publikováno v: Magnetic Resonance in Medicine. 79:41-47

Purpose The most common γ-aminobutyric-acid (GABA) editing approach, MEGA-PRESS, uses J-editing to measure GABA distinct from larger overlapping metabolites, but suffers contamination from coedited macromolecules (MMs) comprising 40 to 60% of the ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2770cdf0b175837780bbeeeaaa0cd92c
https://doi.org/10.1002/mrm.26691

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In vivo assessment of intracellular redox state in rat liver using hyperpolarized [1‐ 13 C]Alanine

Autor: Jae Mo Park, Daniel M. Spielman, Chalermchai Khemtong, Ralph E. Hurd, Shie Chau Liu

Publikováno v: Magnetic Resonance in Medicine. 77:1741-1748

PURPOSE The intracellular lactate to pyruvate concentration ratio is a commonly used tissue assay biomarker of redox, being proportional to free cytosolic [NADH]/[NAD+ ]. In this study, we assessed the use of hyperpolarized [1-13 C]alanine and the su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2db4991d9c3c81d8f8764ccb06574af
https://doi.org/10.1002/mrm.26662

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