Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Ralph E Parchment"'
Autor:
Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199361 (2018)
The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis, necessitating the development of reagents fo
Externí odkaz:
https://doaj.org/article/f5177b4e279648b6b9d11f4b1381c950
Autor:
Jiuping Ji, Yiping Zhang, Christophe E Redon, William C Reinhold, Alice P Chen, Laura K Fogli, Susan L Holbeck, Ralph E Parchment, Melinda Hollingshead, Joseph E Tomaszewski, Quentin Dudon, Yves Pommier, James H Doroshow, William M Bonner
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171582 (2017)
Phosphorylated H2AX (γ-H2AX) is a sensitive marker for DNA double-strand breaks (DSBs), but the variability of H2AX expression in different cell and tissue types makes it difficult to interpret the meaning of the γ-H2AX level. Furthermore, the assa
Externí odkaz:
https://doaj.org/article/c5271db0c4334b48803bddf775b6a904
Autor:
Priya Balasubramanian, Robert J Kinders, Shivaani Kummar, Vishal Gupta, David Hasegawa, Anoop Menachery, Scott M Lawrence, Lihua Wang, Katherine Ferry-Galow, Darren Davis, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175414 (2017)
Circulating tumor cells (CTCs) are increasingly employed for research and clinical monitoring of cancer, though most current methods do not permit the isolation of non-epithelial tumor cells. Furthermore, CTCs isolated with antibody-dependent methods
Externí odkaz:
https://doaj.org/article/5a1c9b8ca8394270b95ad7bdc380301a
Autor:
Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTHistone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such t
Externí odkaz:
https://doaj.org/article/76cdf0bfff0e453b87e8b5bd10e9b649
Autor:
Thomas D Pfister, Melinda Hollingshead, Robert J Kinders, Yiping Zhang, Yvonne A Evrard, Jiuping Ji, Sonny A Khin, Suzanne Borgel, Howard Stotler, John Carter, Raymond Divelbiss, Shivaani Kummar, Yves Pommier, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50494 (2012)
Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial demonstrated that nuclear staining of Top1 correlates with chemotherapeutic efficacy. Such a c
Externí odkaz:
https://doaj.org/article/fc45c0d607034df99dbf3dba3216402a
Autor:
Jiuping Ji, Robert J Kinders, Yiping Zhang, Larry Rubinstein, Shivaani Kummar, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26152 (2011)
Poly(ADP-ribose) polymerase (PARP) facilitates DNA repair and PARP inhibitors may potentiate the effect of DNA-damaging chemotherapeutic agents in patients with cancer. Collection of peripheral blood mononuclear cells (PBMCs) as a surrogate tissue to
Externí odkaz:
https://doaj.org/article/c2dc595de21b4c068a9d2e559732574d
Autor:
Zibo Chen, Lin Zheng, Yulong Chen, Xiuxia Liu, Masanori Kawakami, Lisa Maria Mustachio, Jason Roszik, Katherine V. Ferry-Galow, Ralph E. Parchment, Xin Liu, Thorkell Andresson, Gerard Duncan, Jonathan M. Kurie, Jaime Rodriguez-Canales, Xi Liu, Ethan Dmitrovsky
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 265-280 (2022)
Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of cancer mortality. We previously reported increased ubiquitin-specific peptidase 18 (USP18)
Externí odkaz:
https://doaj.org/article/89c6b8309f354ba2877fae72139376be
Autor:
Yulia Y. Tyurina, Alexandr A. Kapralov, Vladimir A. Tyurin, Galina Shurin, Andrew A. Amoscato, Dhivyaa Rajasundaram, Hua Tian, Yuri L. Bunimovich, Yulia Nefedova, William G. Herrick, Ralph E. Parchment, James H. Doroshow, Hulya Bayir, Apurva K. Srivastava, Valerian E. Kagan
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102650- (2023)
Growing cancer cells effectively evade most programs of regulated cell death, particularly apoptosis. This necessitates a search for alternative therapeutic modalities to cause cancer cell's demise, among them – ferroptosis. One of the obstacles to
Externí odkaz:
https://doaj.org/article/456757eed77a40cd9dc6f115fa83021a
Autor:
Ralph E. Parchment, James H. Doroshow, Robert J. Kinders, John J. Wright, Donald P. Bottaro, James O. Peggins, Melanie A. Simpson, Dane Liston, Joseph M. Covey, Jeevan Prasaad Govindharajulu, Melinda G. Hollingshead, Apurva K. Srivastava
The development of molecularly targeted agents has benefited from use of pharmacodynamic markers to identify “biologically effective doses” (BED) below MTDs, yet this knowledge remains underutilized in selecting dosage regimens and in comparing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::505a5b903a222864e5ba59e4d5938957
https://doi.org/10.1158/1535-7163.c.6538198.v1
https://doi.org/10.1158/1535-7163.c.6538198.v1
Autor:
Apurva K. Srivastava, Ralph E. Parchment, James H. Doroshow, Brigitte C. Widemann, Alice P. Chen, Barry C. Johnson, Andrea M. Gross, Geraldine O'Sullivan Coyne, Dominic Esposito, Melinda G. Hollingshead, Casey L. Kilpatrick, William G. Herrick
This document includes Supplementary Methods, validation data (Figures S1 and S2), complete PD data sets (Figures S3-S7), and Supplementary Tables detailing statistical analyses and assay validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2112c24bc490ca09fb4765d6616478c1
https://doi.org/10.1158/1535-7163.22520812.v1
https://doi.org/10.1158/1535-7163.22520812.v1