Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ralph Dornburg"'
Autor:
Roger J. Pomerantz, Ralph Dornburg, Muhammad Mukhtar, Zahida Parveen, David S. Strayer, Elena Marusich
Publikováno v:
Virology. 332(1):258-271
In this study, we report on the efficacy of using a spleen necrosis virus (SNV)-based vector delivery system to block human immunodeficiency virus type I (HIV-1) replication in human hematopoietic cells. These efforts were directed towards the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9eb57e06999a24231d01f105866257
Publikováno v:
Molecular Therapy. 9(4):557-565
RNA splicing is a complex event in the retroviral life cycle and can involve multiple steps, as well as cis-acting sequences, to maintain a proper balance of spliced and unspliced viral RNA for translation and encapsidation. The retroviral RNA can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e3d52756e3e2917bd97f9de9b9f81e
Publikováno v:
Frontiers in Bioscience. 8:s156-174
Lentiviruses belong to a subfamily of the retroviruses usually associated with persistent infections in animals and humans. They have complex replication cycles involving numerous regulatory and accessory proteins, which sets them apart from the onco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3027b532462ca327713a4f299ccc88da
https://doi.org/10.2741/935
https://doi.org/10.2741/935
Autor:
Ralph Dornburg
Publikováno v:
Frontiers in Bioscience. 8:d818-835
Retrovirus-derived gene transfer systems (retroviral vectors) are the most commonly used gene transfer tools in modern biology. They have been used to study various aspects of retroviral replication, the organization and function of oncogenes and oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0a02c4136362566e006bb43b2460f0
https://doi.org/10.2741/967
https://doi.org/10.2741/967
Publikováno v:
Scopus-Elsevier
The method of delivering a therapeutic gene into a patient is still one of the major obstacles towards successful human gene therapy. Here we describe a novel gene delivery approach using TheraCyte immunoisolation devices. Retroviral vector producing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e31dea44476b350a7ce6a9fc4761bb0
https://doi.org/10.2741/951
https://doi.org/10.2741/951
Autor:
Klaus Cichutek, Roger J. Pomerantz, Zahida Parveen, Anna Krupetsky, Ralph Dornburg, Martin Engelstädter
Publikováno v:
Nature Biotechnology. 18:623-629
Gene therapy applications of retroviral vectors derived from C-type retroviruses have been limited to introducing genes into dividing target cells. Here, we report genetically engineered C-type retroviral vectors derived from spleen necrosis virus (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a165aa9fb7430955bea313412e607456
https://doi.org/10.1038/76458
https://doi.org/10.1038/76458
Autor:
Te-Hua Tearina Chu, Klaus Cichutek, Reinhard Kurth, Martin Engelstädter, Maria Bobkova, Ralph Dornburg, Michael Baier, Christian J. Buchholz, Nicola Holtkamp, Jörn Stitz
Publikováno v:
Human Gene Therapy. 11:293-303
To generate T cell-specific retroviral vectors an scFv phage display library derived from immunized mice was selected for binding to the human T cell line Molt-4/8. The scFv cDNAs recovered from the selected phages were transiently expressed as an N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36eefc8d0adfca5be08202d98845df7
https://doi.org/10.1089/10430340050016030
https://doi.org/10.1089/10430340050016030
Publikováno v:
Human Gene Therapy. 10:2627-2636
We reported that SNV-derived retroviral vectors, which display single-chain antibodies on the viral surface, enable cell type-specific gene delivery into various human cells. In particular, the SNV cell type-specific gene delivery vector system appea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0348d9002d56324e31cff070dea72d
https://doi.org/10.1089/10430349950016663
https://doi.org/10.1089/10430349950016663
Publikováno v:
Journal of Virology. 72:10148-10156
The successful application of human gene therapy protocols on a broad clinical basis will depend on the availability of in vivo cell-type-specific gene delivery systems. We have developed retroviral vector particles, derived from spleen necrosis viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4062c25581d2bfd4f7d1b060c539213c
https://doi.org/10.1128/jvi.72.12.10148-10156.1998
https://doi.org/10.1128/jvi.72.12.10148-10156.1998
Autor:
Ralph Dornburg, Idali Martinez
Publikováno v:
Human Gene Therapy. 7:705-712
Contamination of retroviral vector preparations with replication-competent retroviruses is a major safety concern in human gene therapy. These can arise by recombination between retroviral vectors and packaging cell sequences. Recently, we constructe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f77956eb54d39f6f99d48b09483246
https://doi.org/10.1089/hum.1996.7.6-705
https://doi.org/10.1089/hum.1996.7.6-705