Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.

Autor: Lubow J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America., Levoir LM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America., Ralph DK; Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America., Belmont L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America., Contreras M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America., Cartwright-Acar CH; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America., Kikawa C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.; Medical Scientist Training Program, University of Washington, Seattle, Washington, United States of America., Kannan S; Integral Molecular, Inc., Philadelphia, Pennsylvania, United States of America., Davidson E; Integral Molecular, Inc., Philadelphia, Pennsylvania, United States of America., Duran V; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America., Rebellon-Sanchez DE; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia., Sanz AM; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia., Rosso F; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia.; Department of Internal Medicine, Division of Infectious Diseases, Fundación Valle del Lili, Cali, Colombia., Doranz BJ; Integral Molecular, Inc., Philadelphia, Pennsylvania, United States of America., Einav S; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.; Chan Zuckerberg Biohub, San Francisco, California, United States of America.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America., Matsen Iv FA; Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.; Department of Statistics, University of Washington, Seattle, Washington, United States of America.; Howard Hughes Medical Institute, Seattle, Washington, United States of America., Goo L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Oct 09; Vol. 19 (10), pp. e1011722. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection.

Autor: Shipley MM; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States., Mangala Prasad V; Department of Medicinal Chemistry, University of Washington, Seattle, United States., Doepker LE; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States., Dingens A; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States., Ralph DK; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States., Harkins E; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States., Dhar A; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States., Arenz D; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States., Chohan V; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States., Weight H; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States., Mandaliya K; Coast Provincial General Hospital, Women's Health Project, Mombasa, Kenya., Bloom JD; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.; Department of Genome Sciences, University of Washington, Seattle, United States.; Howard Hughes Medical Institute, Chevy Chase, United States., Matsen FA 4th; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States., Lee KK; Department of Medicinal Chemistry, University of Washington, Seattle, United States., Overbaugh JM; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States.

Publikováno v: ELife [Elife] 2021 Jul 15; Vol. 10. Date of Electronic Publication: 2021 Jul 15.

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses.

Autor: Ruiz, Felicitas^1,2 (AUTHOR), Foreman, William B.³ (AUTHOR), Lilly, Michelle¹ (AUTHOR), Baharani, Viren A.^4,5 (AUTHOR), Depierreux, Delphine M.¹ (AUTHOR), Chohan, Vrasha¹ (AUTHOR), Taylor, Ashley L.³ (AUTHOR), Guenthoer, Jamie¹ (AUTHOR), Ralph, Duncan⁶ (AUTHOR), Matsen IV, Frederick A.^6,7 (AUTHOR), Chu, Helen Y.⁸ (AUTHOR), Bieniasz, Paul D.^4,9 (AUTHOR), Côté, Marceline¹⁰ (AUTHOR), Starr, Tyler N.³ (AUTHOR) tyler.starr@biochem.utah.edu, Overbaugh, Julie^1,6 (AUTHOR) joverbau@fredhutch.org

Publikováno v: PLoS Pathogens. 10/28/2024, Vol. 20 Issue 10, p1-32. 32p.

Using B cell receptor lineage structures to predict affinity.

Autor: Ralph DK; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Matsen FA 4th; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2020 Nov 11; Vol. 16 (11), pp. e1008391. Date of Electronic Publication: 2020 Nov 11 (Print Publication: 2020).

Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to pneumococcal vaccination.

Autor: Morgan, Duncan M.^1,2 (AUTHOR), Zhang, Yiming J.^1,3 (AUTHOR), Kim, Jin-Hwan⁴ (AUTHOR), Murillo, MaryAnn⁴ (AUTHOR), Singh, Suddham⁴ (AUTHOR), Loschko, Jakob^4,5 (AUTHOR), Surendran, Naveen⁴ (AUTHOR), Sekulovic, Ognjen⁴ (AUTHOR), Feng, Ellie^1,3 (AUTHOR), Shi, Shuting^1,2 (AUTHOR), Irvine, Darrell J.^1,3,6,7 (AUTHOR), Patil, Sarita U.⁸ (AUTHOR), Kanevsky, Isis⁴ (AUTHOR), Chorro, Laurent^4,9 (AUTHOR), Christopher Love, J.^1,2 (AUTHOR) clove@mit.edu

Publikováno v: Communications Biology. 9/28/2024, Vol. 7 Issue 1, p1-18. 18p.