Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Ralph D, Sanderson"'
Autor:
Robert P. Richter, James D. Odum, Camilla Margaroli, Jessica C. Cardenas, Lei Zheng, Kaushlendra Tripathi, Zhangjie Wang, Katelyn Arnold, Ralph D. Sanderson, Jian Liu, Jillian R. Richter
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Heparan sulfate (HS) in the vascular endothelial glycocalyx (eGC) is a critical regulator of blood vessel homeostasis. Trauma results in HS shedding from the eGC, but the impact of trauma on HS structural modifications that could influe
Externí odkaz:
https://doaj.org/article/9239c9e753ab4de0b3413a2947abf746
Autor:
Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, Preeti Singh, Gil Bar-Sela, Hadassah Goldberg, Martin Götte, Andrew D. Sharrocks, Yaoyong Li, Ralph D. Sanderson, Neta Ilan, Israel Vlodavsky
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-13 (2024)
Abstract Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we f
Externí odkaz:
https://doaj.org/article/09ad1fee324e44e58f2c01dcb813d1a6
Autor:
Jillian R. Richter, Ralph D. Sanderson
Publikováno v:
Matrix Biology Plus, Vol 17, Iss , Pp 100128- (2023)
Externí odkaz:
https://doaj.org/article/4cee6007c38246249cfc048e8ae60752
Autor:
Robert P. Richter, Amit R. Ashtekar, Lei Zheng, Danielle Pretorius, Tripathi Kaushlendra, Ralph D. Sanderson, Amit Gaggar, Jillian R. Richter
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical outcomes. We have previously observed that biomarkers of endothelial glycocalyx
Externí odkaz:
https://doaj.org/article/09c6efd531964cad857260ed54088102
Autor:
Olga Ostrovsky, Katia Beider, Hila Magen, Merav Leiba, Ralph D. Sanderson, Israel Vlodavsky, Arnon Nagler
Publikováno v:
Cells, Vol 12, Iss 6, p 913 (2023)
Multiple myeloma (MM) is a plasma cell malignancy that is accompanied by hypercalcemia, renal failure, anemia, and lytic bone lesions. Heparanase (HPSE) plays an important role in supporting and promoting myeloma progression, maintenance of plasma ce
Externí odkaz:
https://doaj.org/article/96093207e230487dbe545e4390f6fa9f
Autor:
Jerome T. Higgs, Joo Hyoung Lee, Hong Wang, Vishnu C. Ramani, Diptiman Chanda, Cherlene Y. Hardy, Ralph D. Sanderson, Selvarangan Ponnazhagan
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2375-2385 (2017)
Abstract: The current treatment options for multiple myeloma (MM) osteolytic lesions are mainly combinations of chemotherapy and other small-molecule inhibitors, but toxic side effects still remain a major concern. Studies have shown that osteoclast
Externí odkaz:
https://doaj.org/article/8b5854e28aa24631a1d2598960c4140b
Materials and Methods that apply to the supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e162a5cfb9d6dadbccd88cbb22f83880
https://doi.org/10.1158/0008-5472.22411506
https://doi.org/10.1158/0008-5472.22411506
Autor:
Israel Vlodavsky, Neta Ilan, Yuval Shaked, Ralph D. Sanderson, Miriam Gross-Cohen, JingJing Liu, Shi-Ming Yang, Uri Barash, Ilanit Boyango, Tal Kan, Lilach Gutter-Kapon, Udayan Bhattacharya
Suppl. Figure legends Suppl. Fig. 1. The structure of H1001, a small molecule heparanase inhibitor. H1001 inhibit heparanase activity inside and outside the cell, and attenuates cellular invasion Suppl. Fig. 2. Medium conditioned by PCT-treated macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbd73af06bea0074fecf9be0c57ea1e
https://doi.org/10.1158/0008-5472.22423773.v1
https://doi.org/10.1158/0008-5472.22423773.v1
Legends for supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ada6ed622708aa0c4c638d327927b11
https://doi.org/10.1158/0008-5472.22411509
https://doi.org/10.1158/0008-5472.22411509
Autor:
Israel Vlodavsky, Neta Ilan, Yuval Shaked, Ralph D. Sanderson, Miriam Gross-Cohen, JingJing Liu, Shi-Ming Yang, Uri Barash, Ilanit Boyango, Tal Kan, Lilach Gutter-Kapon, Udayan Bhattacharya
The emerging role of heparanase in tumor initiation, growth, metastasis, and chemoresistance is well recognized, encouraging the development of heparanase inhibitors as anticancer drugs. Unlike the function of heparanase in cancer cells, little atten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::010b772d3da80a80c39713dc30d4addf
https://doi.org/10.1158/0008-5472.c.6511578.v1
https://doi.org/10.1158/0008-5472.c.6511578.v1