Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ralph C. Sigerson"'
Autor:
Oliver Hoult, Ameer K. Ibraheem, Ralph C. Sigerson, Paul M. Gillespie, Karl Broberg, David J. Klauber, Helen Benson, Guillaume Janin, Chris D. Parsons, James Douglas, Bradley W. V. Adams, Sophie Janbon
Publikováno v:
Organic Process Research & Development. 23:62-68
An efficient route to AZD4635 has been developed utilizing the Suzuki–Miyaura reaction of a boronate ester prepared by C–H borylation on a multikilogram scale. Preparation of the cross-coupling partner using bromine/pyridine/methanol has highligh
Autor:
Guillaume Marie, Jennifer S. Mathieson, Leroy Cronin, Philip J. Kitson, Sergey S. Zalesskiy, Ralph C. Sigerson, Jean-Patrick Francoia
Publikováno v:
Science
A plastic plan for organic synthesis The infrastructure for chemical synthesis typically lies at either end of a spectrum: small-scale studies in ad hoc assemblies of glassware or large-scale production in capital-intensive custom reactors. Kitson et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435e8111b6820e11ee52cbc3eb5785ea
https://eprints.gla.ac.uk/156447/1/156447.pdf
https://eprints.gla.ac.uk/156447/1/156447.pdf
Publikováno v:
Tetrahedron. 65:9481-9486
Asymmetric reduction of prochiral ketimines 1a–f with trichlorosilane can be catalyzed by the Lewis-basic formamides (S)-4a,b, derived from N-methyl valine, with ≤91% enantioselectivity and low catalyst loading (≤5 mol %) at room temperature in