Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ralph Breitenbach"'
Autor:
Frank J. Urban, Ralph Breitenbach
Publikováno v:
Synthetic Communications. 29:645-653
A synthesis of 6-nitro and 6-amino 2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolines using a bis-alkylation process is described. 5-(Aminomethyl)-1-(p-methoxybenzyl)-triazole was prepared by a regioselective route from 1,2,4-triazole.
Autor:
Peter J. Daniels, Sally Gut, Peter J. Dunn, and Susan L. Orrill, Ralph Breitenbach, Richard A. Buzon, Lehner Richard S, Frank J. Urban, Jr.† Harry A. Watson
Publikováno v:
Organic Process Research & Development. 2:66-70
This paper describes process research leading to the successful scale-up of a potent cholesterol absorption inhibitor 4‘‘,6‘‘-bis((2-fluorophenyl)carbamoyl)hecogenyl β-O-cellobioside 3. The synthesis of 3 from hecogenyl β-O-cellobioside 4 r
Publikováno v:
Organic Process Research & Development. 1:131-136
An efficient synthesis of the CCKB antagonist N-tert-butyl-2-{3(R)-[3-(3-chlorophenyl)ureido]-8-methyl-2-oxo-5(R)-phenyl-1,3,4,5-tetrahydrobenz[b]azepin-1-yl}acetamide [(R)-1a] in optically active form is presented. The synthesis of the core 3-amino-
Publikováno v:
Synthetic Communications. 26:2241-2247
A synthesis of N-(8-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz[b]azepin-3-yl)-benzamide 2 via an intramolecular amidoalkylation is described.
Publikováno v:
Synthetic Communications. 26:1629-1638
A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the ortho-chlorine for displacement and the methyl group for enamine formation and introduction of the piperaz
Autor:
Thomas Staigers, Susan L. Pezzullo, Chiu Charles K, Ralph Breitenbach, Stephen S. Massett, Morgan Meltz, C.William Murtiashaw
Publikováno v:
Tetrahedron: Asymmetry. 7:435-442
Chiral 3-methyl-heptanoic acid is readily accessible by functional group manipulation of optically active citronellol. In principle, this approach is general and could be applied to the synthesis of chiral 3-methyl-alkanoic acids seven carbon atoms i
Publikováno v:
Tetrahedron: Asymmetry. 6:321-324
A synthesis of an optically active octahydro-2H-pyrido[1,2-a]pyrazine is presented. The key sequence involved the equilibration of an optically active cis-aldehyde to give the thermodynamic trans-aldehyde that was trapped by nitromethane anion.
Publikováno v:
ChemInform. 26
A synthesis of an optically active octahydro-2H-pyrido[1,2-a]pyrazine is presented. The key sequence involved the equilibration of an optically active cis-aldehyde to give the thermodynamic trans-aldehyde that was trapped by nitromethane anion.
Publikováno v:
ChemInform. 27
Publikováno v:
ChemInform. 27
A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the ortho-chlorine for displacement and the methyl group for enamine formation and introduction of the piperaz