Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ralph Brattsand"'
Autor:
Ralph Brattsand, Olof Selroos
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 503 (2024)
The introduction of inhaled corticosteroids (ICSs) changed over a few decades the treatment focus of mild-to-moderate asthma from bronchodilation to reduction in inflammation. This was achieved by inhaling a suitable corticosteroid (CS), giving a hig
Externí odkaz:
https://doaj.org/article/d51158b0fdca4c28ac2037c49eac5238
Autor:
Ralph Brattsand, Olof Selroos
Publikováno v:
Pulmonary pharmacologytherapeutics. 77
The claimed functional basis for ICSs in asthma and COPD is airway selectivity, attained by inhaling a potent, lipophilic compound with long local dissolution/absorption time. The development has been empirically based, resulting in five widely used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33872034330e9383188013e84348131b
https://pubmed.ncbi.nlm.nih.gov/36180011
https://pubmed.ncbi.nlm.nih.gov/36180011
Publikováno v:
Drugs
Drugs, vol 79, iss 16
Drugs, vol 79, iss 16
Airway inflammation is a major contributing factor in both asthma and chronic obstructive pulmonary disease (COPD) and represents an important target for treatment. Inhaled corticosteroids (ICS) as monotherapy or in combination therapy with long-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c999d6b354a2c38763b572945c2e95af
https://doi.org/10.1007/s40265-019-01198-7
https://doi.org/10.1007/s40265-019-01198-7
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 55:341-347
Background LC-MS/MS methods offer high selectivity in cortisol determinations. However, endogenous steroid metabolites may still interfere and compromise the results, for example in the diagnosis of Cushing’s syndrome. Erroneously elevated cortisol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a08b1fded24b74f61f984f82a6be2a
https://doi.org/10.1177/0004563217724178
https://doi.org/10.1177/0004563217724178
Publikováno v:
Drugs, vol 79, iss 17
Airway inflammation is a major contributing factor in both asthma and chronic obstructive pulmonary disease (COPD) and represents an important target for treatment. Inhaled corticosteroids (ICS) as monotherapy or in combination therapy with long-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ca692195bd0c6cd69020d8cc8be308
https://escholarship.org/uc/item/9sh75014
https://escholarship.org/uc/item/9sh75014
Autor:
Ralph Brattsand, Lennart Harthon
Publikováno v:
Acta Pharmacologica et Toxicologica. 36:203-214
Some pharmacokinetic properties of nicotinic acid (NA) and niceritrol (pentaerythritoltetranicotinate) were investigated in rabbits. Niceritrol released NA at a faster rate on incubation in vitro with plasma or liver homogenate than in a pure buffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2340e0c97e5c455ee4c4ba91beb2374e
https://doi.org/10.1111/j.1600-0773.1975.tb00788.x
https://doi.org/10.1111/j.1600-0773.1975.tb00788.x
Publikováno v:
Journal of medicinal chemistry. 46(16)
Crohn's disease is a chronic inflammatory bowel disease characterized by inflammation of both the small and large intestines. Methotrexate (MTX), a classical dihydrofolate reductase (DHFR) inhibitor, has been used as a therapeutic agent in the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d6bba91cee4312e9f1bae69a11967
https://pubmed.ncbi.nlm.nih.gov/12877583
https://pubmed.ncbi.nlm.nih.gov/12877583
Autor:
Katsuhiko Yamada, Ralph Brattsand, James C. Hogg, Anders Valeur, Shizu Hayashi, W. Mark Elliott
Publikováno v:
The Journal of allergy and clinical immunology. 109(1)
Background: We recently reported that allergic lung inflammation in guinea pigs became steroid resistant in the presence of latent adenoviral infection. Objective: We sought to investigate the molecular mechanisms that underlie steroid resistance in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29a4c2b516c1fb13c381c289cbcc7b0
https://pubmed.ncbi.nlm.nih.gov/11799363
https://pubmed.ncbi.nlm.nih.gov/11799363
Autor:
James C. Hogg, W. Mark Elliott, Katsuhiko Yamada, Clive R. Roberts, Shizu Hayashi, Ralph Brattsand, Timothy Z. Vitalis
Publikováno v:
The Journal of allergy and clinical immunology. 106(5)
Background: Steroid-resistant asthma develops after adenoviral bronchiolitis. Objective: We sought to determine the effect of steroids on allergic lung inflammation in the presence of latent adenoviral infection. Methods: Guinea pigs with latent aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8cc24f22239c472adc6f9893c1d1b9
https://pubmed.ncbi.nlm.nih.gov/11080702
https://pubmed.ncbi.nlm.nih.gov/11080702