Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ralph B. Perkerson"'
Autor:
Kshama Gupta, Ralph B. Perkerson, Tammee M. Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D. Burgess, Yingxue Ren, Pamela J. McLean, Debabrata Mukhopadhyay, Prasanna Vibhute, Zbigniew K. Wszolek, Abba C. Zubair, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Radiation therapy is the standard of care for central nervous system tumours. Despite the success of radiation therapy in reducing tumour mass, irradiation (IR)-induced vasculopathies and neuroinflammation contribute to late-delay
Externí odkaz:
https://doaj.org/article/24c38dbdcbff4be1bdca3df216a51ac3
Autor:
Jeremy D. Burgess, Danilyn Amerna, Emily S. Norton, Tammee M. Parsons, Ralph B. Perkerson, Ayman H. Faroqi, Zbigniew K. Wszolek, Hugo Guerrero Cazares, Takahisa Kanekiyo, Marion Delenclos, Pamela J. McLean
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) have a dynamic secretome that plays a critical role in tissue repair and regeneration. However, studying the MSC secretome in mixed-culture disease models remains challenging. This study aimed to d
Externí odkaz:
https://doaj.org/article/26b95de1f2774f8b9a09c407294b15bf
Autor:
Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Cerebrovasculature is critical in maintaining brain homeostasis; its dysregulation often leads to vascular cognitive impairment and dementia (VCID) during aging. VCID is the second most prevalent cause of dementia in the elderly, after Alzheimer’s
Externí odkaz:
https://doaj.org/article/3982980e6d7948619fd5c5933bf5242e
Autor:
Alexandra M. Nicholson, Xiaolai Zhou, Ralph B. Perkerson, Tammee M. Parsons, Jeannie Chew, Mieu Brooks, Mariely DeJesus-Hernandez, NiCole A. Finch, Billie J. Matchett, Aishe Kurti, Karen R. Jansen-West, Emilie Perkerson, Lillian Daughrity, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips, Fenghua Hu, Tania F. Gendron, Melissa E. Murray, Dennis W. Dickson, John D. Fryer, Leonard Petrucelli, Rosa Rademakers
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Loss-of-function mutations in progranulin (GRN) and a non-coding (GGGGCC)n hexanucleotide repeat expansions in C9ORF72 are the two most common genetic causes of frontotemporal lobar degeneration with aggregates of TAR DNA binding protein 43
Externí odkaz:
https://doaj.org/article/80b59b9ee2f04833abccd21624f3cfba
Autor:
Alexandra M. Nicholson, NiCole A. Finch, Marcio Almeida, Ralph B. Perkerson, Marka van Blitterswijk, Aleksandra Wojtas, Basar Cenik, Sergio Rotondo, Venette Inskeep, Laura Almasy, Thomas Dyer, Juan Peralta, Goo Jun, Andrew R. Wood, Timothy M. Frayling, Christian Fuchsberger, Sharon Fowler, Tanya M. Teslovich, Alisa K. Manning, Satish Kumar, Joanne Curran, Donna Lehman, Goncalo Abecasis, Ravindranath Duggirala, Cyril Pottier, Haaris A. Zahir, Julia E. Crook, Anna Karydas, Laura Mitic, Ying Sun, Dennis W. Dickson, Guojun Bu, Joachim Herz, Gang Yu, Bruce L. Miller, Shawn Ferguson, Ronald C. Petersen, Neill Graff-Radford, John Blangero, Rosa Rademakers
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Increasing progranulin (PGRN) levels is a promising approach for treating frontotemporal dementia and other neurodegenerative diseases. Here Nicholson et al.show that the prosaposin (PSAP) locus is associated with plasma PGRN levels and demonstrate t
Externí odkaz:
https://doaj.org/article/69727bed9cd74c41b1fff7349a1c4efe
Autor:
Andres Ramos‐Fresnedo, Carlos Perez‐Vega, Ricardo A. Domingo, Seung Jin Lee, Ralph B. Perkerson, Abba C. Zubair, Kanekiyo Takahisa, William Tatum, Alfredo Quinones‐Hinojosa, Erik. H. Middlebrooks, Sanjeet S. Grewal
Publikováno v:
Epilepsia. 63:1607-1618
Drug-resistant epilepsy (DRE) is characterized by recurrent seizures despite appropriate treatment with antiseizure medication (ASM). Due to their regenerative and immunomodulatory potential, therapies with biologics such as mesenchymal stem cells (M
Autor:
Hanna Briemberg, Ian R. A. Mackenzie, Veronica Hirsch-Reinshagen, Rosa Rademakers, Cyril Pottier, Dean Foti, Ging-Yuek Robin Hsiung, Omar A. Alfaify, Ralph B. Perkerson, Matt Baker
Publikováno v:
Amyotroph Lateral Scler Frontotemporal Degener
Mutations in the TANK binding kinase 1 gene (TBK1) are associated with amyotrophic lateral sclerosis and/or frontotemporal dementia; however, the range of clinical phenotypes and neuropathological changes associated with these mutations have not yet
Autor:
Ronald C. Petersen, Leonard Petrucelli, Keith A. Josephs, Jennifer L. Whitwell, Billie J. Matchett, Joseph E. Parisi, Nirubol Tosakulwong, Ralph B. Perkerson, Amanda M. Serie, Stephen D. Weigand, Dennis W. Dickson, David S. Knopman, Matt Baker, Melissa E. Murray, Rosa Rademakers, Clifford R. Jack
Publikováno v:
Acta neuropathologica
TDP-43 is present in a high proportion of aged brains that do not meet criteria for frontotemporal lobar degeneration (FTLD). We determined whether there are distinct TDP-43 types in non-FTLD brains. From a cohort of 553 brains (Braak neurofibrillary
Autor:
John D. Fryer, Matt Baker, Billie J. Matchett, Alexandra M. Nicholson, Wenhui Qiao, Monica Castanedes-Casey, Virginia Phillips, Hung Phuoc Nguyen, Mieu Brooks, Zachary S. Quicksall, Yan W. Asmann, Melissa E. Murray, Shanu F. Roemer, Guojun Bu, Rosa Rademakers, Xiaolai Zhou, Yingxue Ren, Dennis W. Dickson, Ariston L. Librero, Cristhoper H. Fernandez De Castro, Ralph B. Perkerson, Shunsuke Koga, Aishe Kurti
Publikováno v:
Brain Pathology
Brain pathology
Brain pathology
Genetic variants in TMEM106B are a major risk factor for several neurodegenerative diseases including frontotemporal degeneration, limbic-predominant age-related TDP-43 encephalopathy, Parkinson's disease, late-onset-Alzheimer's disease and constitut
Autor:
Albert G. Hakaim, Samuel Nussbaum, Houssam Farres, Mira Shoukry, Takahisa Kanekiyo, Karen Jeong, Ralph B. Perkerson Iii
Publikováno v:
Journal of Vascular Surgery. 74:e297-e298